Author(s): Syed Ansar Ali, Amit Kumar Nayak, Subhasis Banerjee, Kalyan Kumar Sen, Prabhakar T

Email(s): pharmaali2004@gmail.com

DOI: 10.5958/0974-360X.2020.00554.5   

Address: Syed Ansar Ali1*, Amit Kumar Nayak2, Subhasis Banerjee3, Kalyan Kumar Sen3, Prabhakar T1
1Department of Pharmaceutics, Karnataka College of Pharmacy, Bengaluru, Karnataka, India.
2Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India.
3Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
In the present work, in view of the medicinal properties of vetiver oil (extracted from the roots of Vetiveria zizanioides L.), we made an attempt to predict the possible activity of khusinol, khusimol, germacrene D, junipene, ?-muurolene, biclovetivenol, viridiflorene, ß-vetispirene, ß-vetivenene, and ß-caryophyllene with two cannabinoid receptors, CB1 and CB2 (responsible for antidepressant action) via the in silico molecular docking in a way to encapsulate vetiver oil in different gellan gum-based microcapsules for antidepressant activity. The results of the docking analyses demonstrated that khusinol, germacrene D, and ?-muurolene were docked in the CB1 and CB2 receptors, indicating that the vetiver oil-encapsulated formulation could be effective for antidepressant action. Vetiver oil-encapsulated gellan gum-based microcapsules were prepared using gellan gum only, gellan gum-sodium alginate blends and gellan gum-karaya gum blends via the o/w emulsification-ionotropic crosslinking gelation methodology using aqueous solutions of calcium chloride (4 %). The vetiver oil encapsulation within these microcapsules was calculated and found to be ranged in-between 29.61 ± 3.18 % and 52.69 ± 3.31 %. The in vitro releases of encapsulated vetiver oil gellan gum-based microcapsules were found to be sustained over 8 h. Vetiver oil-encapsulated gellan gum-alginate microcapsules (F5) was selected as best formulation, which exhibited highest oil encapsulation (52.69 ± 3.31 %) and more sustained in vitro releasing of vetiver oil (72.15 ± 3.27 %) than other vetiver oil-encapsulated microcapsules formulations. The mean diameter of the F5 microcapsules was measured 650 µm. The in vivo antidepressant activity of F5 microcapsules was evaluated by forced swimming test and tail suspension test in the Swiss albino mice. The results have shown significant antidepressant activity of vetiver oil-encapsulated gellan gum-alginate microcapsules (F5).


Cite this article:
Syed Ansar Ali, Amit Kumar Nayak, Subhasis Banerjee, Kalyan Kumar Sen, Prabhakar T. In silico molecular docking of Vetiver oil and formulation of Vetiver oil-Encapsulated gellan gum-based Microcapsules for Antidepressant activity. Research J. Pharm. and Tech. 2020; 13(7): 3135-3142. doi: 10.5958/0974-360X.2020.00554.5


REFERENCES:
1. Sen SO, Nayak AK, Devbhuti P, Ghosh A. Modification of gums by periodate oxidation: A natural cross-linker. Int J Pharm Pharmaceutical Sci 2019;11: 1-6.
2. Hasnain MS, Rishishwar P, Rishishwar S, Ali S, Nayak AK. Extraction and characterization of cashew tree (Anacardium occidentale) gum; use in aceclofenac dental pastes. Int J Biol Macromol2018; 116: 1074-1081.
3. Sinha Mahapatra S, Mohanta S, Nayak AK. Preliminary investigation on angiogenic potential of Ziziphus oenoplia M. root ethanolic extract by chorioallantoic membrane model. Sci Asia. 2011; 37: 72-74.
4. Nayak AK. Advances in therapeutic protein production and delivery. Int J Pharm Pharmaceut Sci 2010; 2: 1-5.
5. de Oliveira EF, Paula HC, de Paula RC. Alginate/cashew gum nanoparticles for essential oil encapsulation. Colloids Surf B: Biointerf 2014, 113, 146-151.
6. Kim HJ, Chen F, et al., Evaluation of antioxidant activity of Vetiveria zizanioides oil and identification of its antioxidant constituents. J Agric Food Chem 2005; 53: 7691–7695.
7. Weyerstahl P, Marschall H, Splittgerber U, Wolf U, Surburg H. Constituents of Haitian vetiver oil. Flav Frag J. 2000; 15: 395-412.
8. Hewawasam RP, Jayatilaka KAPW. Antioxidant effect of crude water extract of Vetiveria zizanioides (Gramineae) in mice with acetaminophen induced hepatotoxicity. Int J Pharmacog 2015; 2: 11-20.
9. Balasankar D, Vanilarasu K, Selva Preetha P, Rajeswari S, Umadevi M, Bhowmik D. Traditional and medicinal uses of vetiver. J Med Plants Studies 2013; 1: 191-200.
10. Chowdhury AR, Kumar D, Lohani H. GC-MS analysis of essential oils of Vetiveria zizanioides (Linn.) Nash roots. Frag Flav Assoc India J 2002; 4: 33-35.
11. Arctander S. Perfume and flavour materials of natural origin, Arctander-Elizabeth: New Jersey, USA, 1960.
12. Graham ES, Ashton JC, Glass M. Cannabinoid receptors: a brief history and "what's hot. Front Biosci 2009; 14: 944–957.
13. Milivojevic M, Pajic-Lijakovic I, Bugarski B, Nayak AK, Hasnain MS. Gellan gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds.,), Natural Polysaccharides in Drug Delivery and Biomedical Applications, Academic Press, Elsevier Inc., 2019: pp. 145-186.
14. Nayak AK, Pal D, Santra K. Artocarpus heterophyllus L. seed starch-blended gellan gum mucoadhesive beads of metformin HCl. Int J Biol Macromol2014; 65: 329-339.
15. Bera H, Abbasi YF, Hasnain MS, Nayak AK. Sterculia gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds.,), Natural Polysaccharides in Drug Delivery and Biomedical Applications, Academic Press, Elsevier Inc., 2019: pp. 223-247.
16. Nayak, AK, Hasnain MS, Pal D. Gelled microparticles/beads of sterculia gum and tamarind gum for sustained drug release, In: Thakur VK, Thakur MK, (eds.,), Handbook of Springer on Polymeric Gel, Springer International Publishing, Switzerland, 2018, pp. 361-414.
17. Nayak AK, Pal D. Sterculia gum-based hydrogels for drug delivery applications. In: Kalia S, (ed.), Polymeric Hydrogels as Smart Biomaterials, Springer Series on Polymer and Composite Materials, Springer International Publishing, Switzerland, 2016: pp.105-151.
18. Hasnain MS, Rishishwar P, Rishishwar S, Ali S, Nayak AK. Isolation and characterization of Linum usitatisimum polysaccharide to prepare mucoadhesive beads of diclofenac sodium. Int J Biol Macromol2018; 116: 162-172.
19. Nayak AK, Beg S, Hasnain MS, Malakar J, Pal D. Soluble starch-blended Ca2+-Zn2+-alginate composites-based microparticles of aceclofenac: Formulation development and in vitro characterization. Future J Pharm Sci 2018; 4: 63-70.
20. Nayak AK, Pal D, Santra K. Tamarind seed polysaccharide-gellan mucoadhesive beads for controlled release of metformin HCl. Carbohydr Polym 2014; 103: 154-163.
21. Pal D, Nayak AK.Plant polysaccharides-blended ionotropically-gelled alginate multiple-unit systems for sustained drug release, In: Thakur VK, Thakur MK, Kessler MR (eds.,), Handbook of Composites from Renewable Materials, Vol. 6, Polymeric Composites, WILEY-Scrivener, USA; 2017; pp 399-400.
22. Pal D, Nayak AK. Alginates, blends and microspheres: Controlled drug delivery, In: Mishra M, (ed.), Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Taylor & Francis Group, New York, NY 10017, U.S.A., Vol. I, 2015, pp. 89-98.
23. Martins E, Poncelet D, Rodrigues RC, Renard D. Oil encapsulation techniques using alginate as encapsulating agent: applications and drawbacks. J Microencapsul 2017; 34: 754-771.
24. Sultana T, Mannan MA, Ahmed T. Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice. Clin Phytosci 2018 4:5:1-7.
25. Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010; 31(2):455–461.
26. Can A, Dao DT, Arad M, Terrillion CE, Piantadosi SC, Gould TD. The mouse forced swim test. J Vis Exp 2012; 59: e3638.
27. Can A, Dao DT, Terrillion CE, Piantadosi SC, Bhat S, Gould TD. The tail suspension test. J Vis Exp 2012; 59: e3769.

Recomonded Articles:

Author(s): J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Author(s): R. S. Adnaik, P. S. Gavarkar, S. K. Mohite, C, S Magdum

DOI: Not Available         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Ashish Jayant Saraf, Sudhir Pange, Satyajit Deshmukh, Rahul Hajgude

DOI: Not Available         Access: Open Access Read More

Author(s): Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala

DOI: 10.5958/0974-360X.2018.00069.0         Access: Open Access Read More

Author(s): Shinde AD, Bhise SB

DOI: Not Available         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): Maushumi Kulkarni, Rahul Thube, Kiran Bhise, Mohammed Kakajiwala

DOI: Not Available         Access: Open Access Read More

Author(s): Dheeraj Ahirwar, Bharti Ahirwar

DOI: 10.5958/0974-360X.2020.00291.7         Access: Closed Access Read More

Author(s): Mohammed Asif Hussain, K. Sravan, Maimuna Anjum, Nusrath Ayesha

DOI: Not Available         Access: Open Access Read More

Author(s): Satyabrata bhanja, K. Lakshmi Deepthi, Muvvala Sudhakar, Bibhuti Bhusan Panigrahi

DOI: Not Available         Access: Open Access Read More

Author(s): P.N. Remya, H. Gayathri, T.S. Saraswathi, R. Kavitha, S. Sangeetha, N. Damodharan

DOI: 10.5958/0974-360X.2017.00792.2         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags