Author(s):
Shaimaa A. Hassan, Sajid M. Lateef, Ismaeel Y. Majeed
Email(s):
shaimaa80altaee@gmail.com
DOI:
10.5958/0974-360X.2020.00531.4 
Address:
Shaimaa A. Hassan1, Sajid M. Lateef 2, Ismaeel Y. Majeed2
1College of Remote Sensing & Geophysics , AL-karkh University of Science , Iraq.
2Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq.
*Corresponding Author
Published In:
Volume - 13,
Issue - 6,
Year - 2020
ABSTRACT:
A new Schiff base, methyl (E)-(6-(((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)(phenyl)methyl)-1H-benzo[d]imidazol-2-yl)carbamate(L) has been synthesized from 4-aminoantipyrine and mebendazol. Metal complexes of the Schiff base were prepared from metal ions of MII = VO, Mn, Co, Ni, Cu, Zn, Cd and Hg in alcoholic medium with mole ratio (M:L) (1:2). The complexes have general composition [M(L)2Cl2].H2O, [(VO)(L)2(SO4)].H2O, [M(L)2(H2O)Cl].H2O, [Ni(L)2Cl].H2O. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV_Vis,1HNMR,13CNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against two type of bacterial and one type fungus.
Cite this article:
Shaimaa A. Hassan, Sajid M. Lateef, Ismaeel Y. Majeed. Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and it's metal complexes and evaluation of their biological activity. Research J. Pharm. and Tech 2020; 13(6): 3001-3006. doi: 10.5958/0974-360X.2020.00531.4
Cite(Electronic):
Shaimaa A. Hassan, Sajid M. Lateef, Ismaeel Y. Majeed. Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and it's metal complexes and evaluation of their biological activity. Research J. Pharm. and Tech 2020; 13(6): 3001-3006. doi: 10.5958/0974-360X.2020.00531.4 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-84
REFERENCES:
1. Israa A. Hassan,Transtion Metal Complexes of Bidentte Ligand N-aminoquinolino-2-one and Anthranilic Hydrazide, Research Journal of Chemical Sciences, 3 (12), 50-53, (2013)
2. Buttrus H. Nabeel and Saeed T. Synthesis and Structural Studies on Some Transition metal complexes of Bis-(benzimidazole-2-thio) ethane, propane and butane ligands, Research Journal of Chemical Sciences,2(6),43-49, (2012).
3. Z.-L.You and H.-L. Zhu, Syntheses, crystal structures, and antibacterial activities of four schiff base complexes of copper and zinc, Zeitschrift fur Anorganische und Allgemeine Chemie, 630 (15), 2754–2760, (2004).
4. Kabeer A S, Baseer M A, Mote N A, Synthesis and antimicrobial activity of some Schiff bases from Benzothiazoles, Asian. J. Chem., 13(2), 496–500, (2001).
5. Rajasekar K, Ramachandramoorthy T. and Balasubramaniyan S. Synthesis, Spectral characterization and Crystal structure of [Cd(4-AAP) 2(NO2)2] (4-AAP=4-Aminoantipyrine), Research Journal of Chemical Sciences, 3 (3), 48-51 (2013).
6. Desai S B, Desai P B, Desai K R, Synthesis of Some Schiff Bases,Thiazolidinones and Azetidinones Derived From 2, 6-Diaminobenzo [1, 2-D:4, 5-D'] Bisthiazole and their Anticancer Activities, Hetrocycl. Commun. 7 (1):83–90, (2001).
7. Zahid H C, Mohammad S I, Hummara S I, Claudiu T S, Transition Metal Acetylsalicylates and Their Antiinflammatory Activity, Journal of Enzyme Inhibition and Medicinal Chemistry, 17(2), 87, (2002).
8. Sindhukumarn B, Raijuulal G., and Mohanan K,Microwave assisted synthesis, spectroscopic, thermal and biological studies of some Lanthanide (III) chloride complexes with a hetrocyclic Schiff’s bases, Synthesis And Reactivity In Inorganic Metal Organic And Nano-Metal Chemistry,39;24,(2009).
9. Thankamony M. and Mohanan K,Synthesis, spectral studies, thermal decomposition kinetics, reactivity and antibacterial activity of some lanthanide (II) nitrate complexes of 2-(N-indole-2-one) amino-3-carboxyethyl-4-5-6-7-tetrhy-drobenzo[b]thiophene, Indian journal of chemistry A,46,247-251, (2007).
10. Raman N, Dhaveethu Raja J, and Sakthivel A, Synthesis spectral characterization of Schiff base transition metal complexes DNA cleavage and antimicrobial activity studies, Journal of Chemical Sciences, 119(4); 303-310,(2007).
11. Manjula B. and Arul Antony S, Preparation, Characterization, Antimicrobial Activities and DNA Cleavage Studies of Schiff Base Complexes Derived From 4-Amino Antipyrine, Asian Journal of Biochemical and Pharmaceutical Research, 3(1), 168-178 (2013).
12. Silverstein R, Webster F and Kiemle D. Spectrometric identification of organic compounds. 7th edition, John,Wiliy and sons:pp.72_126 (2005).
13. Sie T. Ha, Teck M. Koh, Guan Y. Yeap, Hong Ch. Lin,Jun K. Beh, Yip F. Win, Peng L. Boey. New mesogenic Schiff base esters comprising benzothiazole moiety: Synthesis and mesomorphic properties Studies. Int. J. Electrochem. Sci Perak, Chinese Chemical Letters 201081–1084 (2009).
14. Mistry BA. Handbook of spectroscopic data chemistry. Edition Oxford Book Company Jaipor India, Mehra Offset Printers, Delhi 2009; p.12.
15. H. Dudley Williams and Ian Fleming, "Spectroscopic Methods in Organic Chemistry Third Edition", England, (1980).
16. R.Kalaiselvan, et al;Acta Pharmaceutica Sciencia, 48, 19-33 (2006).
17. M.Tumer, H.Koksal, S.Serin and M.Digrak, Transition Met.Chem., 24, 13 (1999).
18. E. I. Yousif, H. A. Hasan, R. M. Ahmad, M. J. Al-Jeboori,“Formation of macrocyclic complexes with bis (dithiocarbamate) ligand; synthesis, spectral characterisation and bacterial activity” Der Chemica Sinica, 7, 2, 53-65, (2016).
19. T. H. Muat, M.J. Al-Jeboori, “Phenoxo- and azido-bridged complexes with N2OS2 Schiff-base ligand; synthesis, spectral investigation and bacterial activity”, Chem Xpress, 9, 2, 156-171,(2016).
20. Kolcu F, and Kaya I. Synthesis. characterization and photovoltaic studies of oligo (acriflavine) via chemical oxidative polymerization. RSC Adv.; 7: 8973-8984. (2017).
21. Mistry BA. Handbook of spectroscopic data chemistry.edition oxford book company jaipor India,mehra offset printers, Dolhi; p.12 (2009).
22. Matsuyama T, Takagi Y, Nakagawa Y, Itoh H, Wakita J, Matsushita M (January2000). "Dynamic aspects of the structured cell population in a swarming colony of Proteus mirabilis". J. Bacteriol.182(2):385–93. doi:10.1128/JB.182.2.385-393.2000. PMC 94287. PMID 10629184.
23. Y.Liu, N.Zhang, and Y. Wang, L.-H. Org. Lett., 9,) 315(2007).
24. M. R. Islam, J. A. Shampa, M. K. Zahan, M. M. Haque, and Y. Reza. J. Sci. Res. 8(2), 181 (2016). http://dx.doi.org/10.3329/ jsr.v8i2.26332
25. S. Alghool, H, F, A, El-Halim, M. A. El-sadek, I. Yahia, and L. Wahab, J. Therm. Anal. Calorim. 121, 1309 (2015). http://dx.doi.org/ 10.1007/s10973-015-4610-4