Author(s): Bhuvaneshwari S, Umashankar M S, Damodharan N

Email(s): umashankarms.umashankar1@gmail.com

DOI: 10.5958/0974-360X.2020.00528.4   

Address: Bhuvaneshwari S, Umashankar M S*, Damodharan N
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020


ABSTRACT:
Mini tablets constitute a solid dosage form and are more than one-unit dosage, they are advantageous than pellets or another oral dosage forms and greater when given to children and elderly human beings as they may be at ease to swallow. Amongst all MUDFs, mini tablets provide several benefits like they do not require any solvent for their manufacturing, can be coated reproducibly, and also requires much less coating material. Additionally, there's a brilliant flexibility during their formulation development. Dose dumping and local infection may be prevented with the aid of the use of mini tablets. Child differs from grown-up in pharmacotherapy, together with abilities for drug administration, medication-related toxicity, and taste preference. It is vital that pediatric medicines are formulated to foremost acceptable with child’s age, size, physiologic conditions remedy requirements development are important and the research of latest methods to deliver drugs tends to enhance compliance, convenience and pharmacokinetic. Further, recommended that small sized solid dosage forms or orally disintegrating stable dosage forms have to be preferred. Their small size permits them to be nicely distributed alongside the gastrointestinal tract enhancing the bioavailability even as decreasing region drug attention, risk of toxicity and side effects.


Cite this article:
Bhuvaneshwari S, Umashankar M S, Damodharan N. Mini Tablets: Pediatric Drug Delivery System. Research J. Pharm. and Tech 2020; 13(6): 2985-2991. doi: 10.5958/0974-360X.2020.00528.4

Cite(Electronic):
Bhuvaneshwari S, Umashankar M S, Damodharan N. Mini Tablets: Pediatric Drug Delivery System. Research J. Pharm. and Tech 2020; 13(6): 2985-2991. doi: 10.5958/0974-360X.2020.00528.4   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-81


REFERENCES:
1.    Priyanka, Kapil Kumar, Deepak Teotia. A comprehensive review on pharmaceutical mini tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(6):382-390
2.    Motor Leela Keerthi, Shireesh Kiran, Uma Maheshwar Rao et al., Pharmaceutical mini-tablets, its advantages, formulation possibilities and general evaluation aspects: a review. Int. J. Pharm. Sci. Rev. Res., 28(1), September – October 2014; Article No. 40, Pages: 214-221
3.    Asif Shaikh, Vishal Yadav, Prakash Jadhav. An updated review on pharmaceutical mini tablets: formulation and its evaluation. International Journal of Advances in Scientific Research 2019; 5(3): 5109.
4.    Ranjith K, Mahalaxmi R. Pharmaceutical mini tablets. Int. J Pharm Tech Res.2014-2015; 7(3): 507-515.
5.    Verica Ivanovska et al, Pediatric drug formulations: a review of challenges and progress. Pediatrics. August 2014, volume 134, number 2.
6.    María esther martínez-terán, thanh huong hoang-thi and marie-pierre flament. Multi-particulate dosage forms for pediatric use. pediatr ther 2017, 7:1.
7.    Felipe lopez, terry b ernest, catherine tuleu and mine orlu gul, Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert opin. Drug deliv. (2015) 12(11):1727-1740
8.    Mohd. Yousuf Ali et al., Design and Evaluation of Nimesulide Lozenges for Pediatrics. Research journal of Pharmacy and Technology. June- September 2010; 3(3): 818-820.
9.    Punam mistry et al., evidence of acceptability of oral pediatric medicines: a review. Journal of pharmacy and pharmacology published by john wiley and sons ltd on behalf of royal pharmaceutical society, 69 (2017), pp. 361–376
10.    Jembulingam Sabarathinam et al., Assessment of Behavioural Management Techniques of Paediatric Patients Among the Dentist in Chennai: A Questionnaire Study. Research journal of Pharmacy and Technology. February 2016; 9(2): 145-148.
11.    Maren preis and jörg breitkreutz. Pediatric drug development and dosage form design. aaps pharm sci tech, vol. 18, no. 2, February 2017
12.    Karkossa et al., Simulating different dosing scenarios for a child-appropriate valproate formulation in a new pediatric two-stage dissolution model. Aaps pharmscitech. 2016.
13.    Shravan Kumar gunti, Reddy sunil. Design and characterization of sustained release mini-tablets of cefixime trihydrate. International journal of pharmacy and biological sciences. 2014; 4(1): 79-88
14.    Brahmankar and Jaiswal s.b. Biopharmaceutics and pharmacokinetics. A treatise. 1st edn, vallabh prakashan, new delhi, 2007, 335-356.
15.    Deepak garg et al., Oral disintegrating minitablets: mini review. International journal of pharmaceutical sciences (dhr-ijps) issn: 2278-8328, vol. 4, issue 2, 2013.
16.    A. Ramya et al., Assessment of Appropriate use of Antibiotics in Paediatric Department of A Tertiary Care Teaching Hospital. Research journal of Pharmacy and Technology. February 2017; 10(2): 381-384.
17.    R. Bhatia S, Prabhakar VK, Grover. Tetanus, neurol india, 2002; 50: 398-407
18.    Milind S, Tullu chandrahas T, Deshmukh jaishree R, Kamat. Experience of pediatric tetanus cases from mumbai. Indian pediatrics 2000; 37: 765-771
19.    Toivonen et al., Rhinovirus infections in the first 2 years of life, pediatrics volume 138, number 3, September 2016.
20.    Helen y et al., rhinovirus disease in children seeking care in a tertiary pediatric emergency department. Journal of the pediatric infectious diseases society, vol. 5, no. 1, pp. 29–38, 2016.
21.    Jinfeng liu, wei wang, fengli liu and zhenguang li. Pediatric acute respiratory distress syndrome - current views (review). Experimental and therapeutic medicine. 2018: 15: 1775-1780
22.    P. Geetha et al., Prescribing Pattern of Drugs Used For Respiratory Disease in Pediatric Patients at Private Hospital. Research journal of Pharmacy and Technology. March 2016; 9(3): 251-256.
23.    Mohan Mehndiratta et al., Poliomyelitis: historical facts, epidemiology, and current challenges in eradication. The Neuro-Hospitalist 2014, vol. 4(4) 223-229
24.    Janell a. Routh, md, mhs; m. Steven oberste, phd; manisha patel, md, ms, chapter 12: poliomyelitis, VPD Surveillance Manual, Poliomyelitis: Chapter 12.1
25.    Paul et al., Pertussis: microbiology, disease, treatment, and prevention, Clinical Microbiology Reviews. July 2016 Volume 29 number 3.
26.    Amal al maani et al., Pertussis and pertussis like illness: pediatric experience in oman, oman med j, vol 32, no5, September 2017.
27.    Fang wang et al., Para influenza virus types 1, 2, and 3 in pediatric patients with acute respiratory infections in beijing during 2004 to 2012, Chinese medical journal. October 20, 2015 volume 128 (20).
28.    S. Nithya et al., A Study on Development and Evaluation of A Paediatric Formulary in A Tertiary Care Hospital. Research journal of Pharmacy and Technology. November 2016; 9(11): 1957-1961.
29.    Young youn choi. Necrotizing enterocolitis in newborns: update in pathophysiology and newly emerging therapeutic strategies. korean j pediatr. 2014; 57(12):505-513.
30.    Cely carolyne pontes morcerf, bruna alves cambraia, fabiana cerqueira abbud, and lucila bragantini prata. Necrotizing enterocolitis: case report with bibliographic review. Pediatric infectious diseases: open access issn 2573-0282, vol.3 no.2:7
31.    C. L. Abad and N. Safdar, the reemergence of measles, curr infect dis rep (2015) 17:51
32.    Gupta R, muhammed S, muhammed Y, sondhi V. Diphtheria: the strangling angel of (older) children, pediatric on call journal april - june 2018; volume 15 (2).
33.    Erin j. Plosa, Jennifer c. Esbenshade, m. Paige fuller and jörn-hendrik weitkamp, cytomegalovirus infection. Pediatrics in review. 2012; 33: 156.
34.    Shristi Nadar et al., Prevalence of Anemia in Urban Children Attending A Pediatric Hospital of A Metro City in South India. Research journal of Pharmacy and Technology. October 2016; 9(10): 1571-1574.
35.    Tawfeek hm, Saleem iy, Matthew roberts. Dissolution enhancement and formulation of rapid-release lornoxicam mini-tablets. Pharmaceutics, drug delivery, and pharmaceutical technology. 2470-2483.
36.    Tony nunn and julie Williams. Formulation of medicines for children. br j clin pharmacol 59; 6: 674–676.
37.    Tan E, cranswick NE, rayner CR, chapman CB. Dosing information for paediatric patients: are they really ‘therapeutic orphans’. Med j aust. 2003; 179 (4): 195–8.
38.    Revision of monograph on capsules. Final text for addition to the international pharmacopoeia, world health organization, march 2011.
39.    A. Mounika, B. Sirisha, and V. Uma maheshwar rao. Pharmaceutical mini tablets, its advantages and different enteric coating processes. World journal of pharmacy and pharmaceutical sciences. Vol 4, issue 08, 2015.
40.    Bruhalkumar A shah et al., Mini-tablet drug delivery system for pediatric dosage form (pdf): a review of manufacturing perspectives. Int j drug dev and res issn: 0975-9344, volume 10(3): 47-52 (2018)-047.
41.    Maren preis. Orally disintegrating films and mini-tablets—innovative dosage forms of choice for pediatric use. aaps pharmscitech, vol. 16, no. 2, april 2015
42.    Ms. Kalaivani R et al., A prospective observational study on the attitude and experience of community pharmacists towards off-label and unlicensed prescriptions for the pediatric population. Research journal of Pharmacy and Technology. January 2017; 10(1): 149-154.
43.    Maheshwari. P et al., Antibiotic Drug Utilization and Evaluation in Pediatric Patients. Research journal of Pharmacy and Technology. August 2017; 10(8): 2704-2706.
44.    Abdul Sayeed et al., Formulation and In vitro Evaluation of Mouth Dissolving Tablets of Carvedilol by Direct Compression Methods. Research Journal of Pharmacy and Technology. December 2012; 5(12): 1525-1531.
45.   Ankit A. Kharia et al., Formulation Strategy for Low Absorption Window Antihypertensive Agent. Research Journal of Pharmacy and Technology. January-March 2010; 3(1): 113-117.

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