Author(s):
Shah V. V., Doijad R. C., Shah N. V.
Email(s):
shahvishalv99@gmail.com
DOI:
10.5958/0974-360X.2020.00518.1 
Address:
Shah V. V.1*, Doijad R. C.2, Shah N. V.3
1Department of Pharmaceutical Chemistry, Krishna Institute of Pharmacy, Karad.
2 Department of Pharmaceutics, Krishna Institute of Pharmacy, Karad.
3Krishna College of Pharmacy, Karad.
*Corresponding Author
Published In:
Volume - 13,
Issue - 6,
Year - 2020
ABSTRACT:
Coumarins are naturally occurring oxygen containing compounds used as lead compounds for designing new potent analogs. They are having various medicinal properties. Present paper involves the synthesis of some novel coumarin analogs which are characterized and screened for their anti-inflammatory activity. All compounds were synthesized by conventional as well as microwave assisted synthesis. The newly synthesized compounds were characterized by IR, 1H NMR. Various coumarin derivatives are directly prepared by reaction of ortho amino phenol and beta keto ester by using titanium chloride dehydrates as catalyst. Later these are converted to Schiff’s bases. This method describes the direct introduction of amino group to the coumarin ring. Synthesized derivatives are screened for the anti-inflammatory activity at two different doses 10 mg/kg and 20 mg/kg. Diclofenac Sodium was utilized as standard.
Cite this article:
Shah V. V., Doijad R. C., Shah N. V. Microwave assisted synthesis of novel Coumarin derivatives for its Anti-Inflammatory applications. Research J. Pharm. and Tech 2020; 13(6): 2906-2911. doi: 10.5958/0974-360X.2020.00518.1
Cite(Electronic):
Shah V. V., Doijad R. C., Shah N. V. Microwave assisted synthesis of novel Coumarin derivatives for its Anti-Inflammatory applications. Research J. Pharm. and Tech 2020; 13(6): 2906-2911. doi: 10.5958/0974-360X.2020.00518.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-68
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