Author(s): M. Mounica, G. Tanuja Lakshmi, K. Manaswini, D. Eswar Tony, A. Narendra Babu


DOI: 10.5958/0974-360X.2020.00513.2   

Address: M. Mounica*, G. Tanuja Lakshmi, K. Manaswini, D. Eswar Tony, A. Narendra Babu
Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020

Ficus hispida (tropical fig tree) is a moderate sized tree which is commonly known as devil fig, traditionally used in the ailment of pain, inflammation, and neurological disorders. Psidium guajava (Guava/peru)is a well-known tropical tree and also used as a folk herbal tea used to treat diabetes and leaves were used as astringent, anodyne, febrifuge, antispasmodic, tonic, in wounds, cholera, lactagouge, diarrhoea, vomiting and variety of diseases like diarrhoea, dysentery, hypertension, gastroenteritis, diabetes, cough, oral ulcers etc., The aim of the present study is set out to evaluate the anti-diabetic activity of ethanolic leaf extracts of ficus hispida and psidium guajava on streptozocin induced diabetized rats. The leaf extracts at a dose of 100mg/kg were screened for their blood glucose lowering effectamong streptozocin induced diabetized rats and the blood samples were collected through the tail vein from which blood glucose levels were determinedat 0h, 1h, 2h and 4hafter administration of test samples. Both the leaf extracts of Ficus hispida and Psidium guajava produced significant (p 0.01) decrease in the blood glucose levels. The ethanolic extract of leaves of Ficus hispida and Psidium guava produced synergistic effect when compared with standard by showing an effective response on diabetic rats. These plants supported the folk fore claim of anti-diabetic activity. Further investigations are needed for the proper identification and isolation of these bioactive compounds to produce safer drugs for treatment of harmful diseases.

Cite this article:
M. Mounica, G. Tanuja Lakshmi, K. Manaswini, D. Eswar Tony, A. Narendra Babu. Synergistic Effect of Leaf Extracts of Ficus hispida and Psidium guajava for Anti-Diabetic Activity on Wistar Rats. Research J. Pharm. and Tech 2020; 13(6): 2877-2880. doi: 10.5958/0974-360X.2020.00513.2

1.    Vikas V. Patil, N. G. Sutar, R. B. Pimprikar, A. P. Patil, R. Y. Chaudhari, V. R. Patil. Antihyperglycemic and hypoglycaemic effect of Ficus racemosa leaves. Journal of natural remedies. 2010; 10(1):11-16.
2.    Md. Sariful Islam Howlader, Md. Afjalus Siraj, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed and Md. Hemayet Hossain. Ficus hispida Bark Extract Prevents Nociception, Inflammation and CNS Stimulation in Experimental Animal Model. Evidence Based Complementary and Alternative Medicine.2017: 1-14.
3.    Mandal SC, Kumar CK. Studies on anti-diarrhoeal activity of Ficus hispida leaf extract in rats. Fitoterapia. 2002; 73(7-8):663–637.
4.    Sivaraman D, Muralidharan P. Anti-ulcerogenic evaluation of root extract of Ficus hispida linn: In aspirin ulcerated rats. African Journal of Pharmacy and Pharmacology. 2010; 4(2):72–82.
5.    T.S. Shanmugarajan, M. Arunsundar, I. Somasundaram, E. Krishnakumar, D. Sivaraman and V. Ravichandiran. Cardioprotective effect of Ficus hispida linn: on cyclophosphamide provoked oxidative myocardial injury in a rat model. International Journal of Pharmacology. 2008; 4(2):78-87.
6.    Sivaraman D, Muralidaran P. Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida linn. Drug Invent Today. 2009; 1(1):27–30.
7.    Huong VN, Trang VM. Hispidin: A strong anticancer agent isolated from the leaves of Ficus hispida L. Vietnam journal of chemistry. 2006; 44(3):345–349.
8.    Vishnoi SP, Jha T. Evaluation of anti-inflammatory activity of leaf extracts of Ficus hispida. Indian Journal of Natural Products. 2004; 20:27-29.
9.    Mandal SC, Saraswathi B, Kumar CK, Lakshmi SM, Maiti BC. Protective effect of leaf extract of Ficus hispida Linn against paracetamol-induced hepatotoxicity in rats. Phytotherapy Research. 2000; 14(6):457–459.
10.    K.S. Chandrashekharaiah Menaka N Bolaki, Gupta Shivani Sanjay, Aanchal Bathija, V Krishna Murthy, M Narayanaswamy and N Ramachandra Swamy. Anti-oxidant and Anti-hyperglycemic Properties of Methanolic Extracts of Medicinal Plants. Biosciences Biotechnology Research Asia; 2013; 10(2): 607-612.
11.    Mohammad Ali, Nisha Chaudhary. Ficus hispida Linn. A review of its pharmacognostic and ethnomedicinal properties. Pharmacognosy Review. 2011; 5(9):96-103.
12.    You Luo, Bin Peng, Weiqian Wei, Xiaofei Tian and Zhenqiang Wu. Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves. Molecules. 2019; 24(7):1343.
13.    Vaidyaratnam P S Varier, Arya Vaidya Sala. Indian Medicinal Plants, Orient Longman Ltd., Madras.1995; Vol. 4: pp. 371
14.    Nadkarni KM. Indian Materia Medica. Popular Prakashan, Bombay.1985; Vol. I:pp. 1019.
15.    Karunakar Shukla, PK Dubey. Antidiabetic Activity of Psidium guajava (Guava) Leaves Extract. Research Journal of Science and Technology. 2009; 1(1): 13-15
16.    M. Shakeera Banu, K. Sujatha, W. Sherly Beena and N. Divya. Antihyperglycemic and Antioxidant potentials Psidium guajava leaf extract and its isolated fraction in alloxan-induced diabetic rats. Research Journal of Pharmacy and Technology. 2012; 5(4): 541-546.
17.    M. Kamala, M. Shakeera Banu, R. Senthil and A. Vijaya Anand. Anti–Hyperglycemic and Anti–Hyperlipidemic Potentials of Psidium guajava Fruit Extract – a Review. Research Journal of Pharmacy and Technology. 2011; 4(7):1033-1036.
18.    N. Divya and S. Ilavenil. Hypoglycemic and Hypolipidemic Potentials of Psidium guajava in Alloxan Induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2012; 5(1):125-128.
19.    Lutterodt GD. Inhibition of Microlax induced experimental diarrhoea with narcotics like extracts of Psidium guajava in rats. Journal of Etahnopharmacology. 1992; 37(2): 151-157.
20.    R. Manikandan, A. Vijaya Anand. A Review on Antioxidant activity of Psidium guajava. Research Journal of Pharmacy and Technology. 2015; 8(3):339-342.
21.    K. Sridivya Goud. Preparation and Evaluation of Mucilage from Fresh Leaves of Psidium guajava. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018; 10(3):125-132.
22.    W. Sherly Beena, K. Vijaya Kumar, M. Shakeera Banu, A. Vijaya Anand, P. Sampath Kumar. Antioxidative Activity of Psidium guajava Leaf Extract- A Review. Research Journal of Pharmacognosy and Phytochemistry. 2011; 3(4): 143-147.
23.    Jairaj P, Khoohaswan P, Wongkrajang Y, Peungvicha P, Suriyawong P, Sumal Sarya ML, Ruangsomboon O. Anti-cough and antimicrobial activities of Psidium guajava Linn. leaf extract. Journal of Etahnopharmacology. 1999; 67(2):203–212.
24.    Olajide OA, Awe SO, Makinde JM. Pharmacological studies on the leaf of Psidium guajava. Fitoterapia. 1999; 70(1): 25–31
25.    Jairaj P, Ongkrajang Y, Thongprenditchote S, Peungvicha P, Bunyaprapha-tatsara N, Opartkiattikul N. Guava leaf extract and topical haemostasis. Phytotherapy Research.2000; 14(5): 388–391
26.    Tone L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. Antiamoebic and phytochemical screening of some Congolese medicinal plants. Journal of Etahnopharmacology. 1998; 61(1): 56–75.
27.    Ravichandra VD, Padmaa M and Paarakh. Pharmacognostic and Phytochemical Investigation on Leaves of ficus hispida. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(2):131-134.
28.    Anonymous. The Wealth of India. NISCOM, CSIR, New Delhi.1998; p. 285-293.
29.    G. Babu, Asish Bhaumik, K. Krishnamachary, P. Kalyani. Synthetic Novel Flavanoid derivatives act as potential Antidiabetic agent against Streptozocin induced in diabetic Rats. Asian Journal of Research in Chemistry.2018; 11(5):799-805.
30.    M.Sugumaran, T. Vetrichelvan and S. Darlin Quine. Antidiabetic potential of aqueous and alcoholic leaf extracts of Pithecellobium dulce. Asian Journal of Research in Chemistry.2009; 2(1):83-85.
31.    B. D. Patel, M. L. Kori. Antidiabetic Effect of Ammania baccifera Linn leaf on Streptozotocin Induced Diabetes in Male Albino Wistar Rats. Research Journal of Pharmacy and Technology. 2018; 11(11): 4773-4780.

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