Author(s): Gunuputi Sushma, Sri Harsha D, Mathrusri Annapurna Mukthinuthalapati

Email(s): mmukthin@gitam.edu

DOI: 10.5958/0974-360X.2020.00505.3   

Address: Gunuputi Sushma, Sri Harsha D, Mathrusri Annapurna Mukthinuthalapati*
Department of Pharmaceutical Analysis, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh-530045, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020


ABSTRACT:
New first derivative spectrophotometric methods have been established for the determination of Sitagliptin in pharmaceutical formulations. Sitagliptin is an oral dipeptidyl peptidase-4 inhibitor which exerts its actions in type 2 diabetes patients by slowing the inactivation of incretin hormones. Sitagliptin is chemically known as (R)-4-oxo-4- [3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo [4,3-a] pyrazin -7(8H) -yl] -1-(2,4,5-trifluoro phenyl)butan-2-amine. First derivative spectrophotometric methods were developed using the reagents 0.1 N NaOH, phosphate buffers (pH 5.0 and 8.0), borate buffer (pH 9.0) and acetate buffer (pH 4.7) and amplitude was taken as the parameter from the derivative spectra to construct the calibration curve. Sitagliptin obeys Beer-Lambert’s law over the concentration range 5-100 µg/ml in all the methods and the methods were validated as per ICH guidelines.


Cite this article:
Gunuputi Sushma, Sri Harsha D, Mathrusri Annapurna Mukthinuthalapati. New first derivative spectrophotometric methods for the determination of Sitagliptin - An antidiabetic agent. Research J. Pharm. and Tech 2020; 13(6): 2838-2842. doi: 10.5958/0974-360X.2020.00505.3

Cite(Electronic):
Gunuputi Sushma, Sri Harsha D, Mathrusri Annapurna Mukthinuthalapati. New first derivative spectrophotometric methods for the determination of Sitagliptin - An antidiabetic agent. Research J. Pharm. and Tech 2020; 13(6): 2838-2842. doi: 10.5958/0974-360X.2020.00505.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-55


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