Author(s): Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna, Rangisetty Spandana Yasaswini

Email(s): mmukthin@gitam.edu

DOI: 10.5958/0974-360X.2020.00502.8   

Address: Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna*, Rangisetty Spandana Yasaswini
Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020


ABSTRACT:
Budesonide is a glucocorticoid used in the long-term management of asthma and chronic obstructive pulmonary disease (COPD). Also used to prevent difficulty breathing, chest tightness, wheezing and coughing caused by asthma. A new stability indicating RP-UFLC method has been developed and validated for the determination of Budesonide in pure and pharmaceutical dosage forms. Shimadzu Model CBM-20A/20 Alite UFLC system (Shimadzu Co., Kyoto, Japan) equipped with SPD M20A prominence photodiode array detector on Agilent C18 column was used with a mobile phase consisting of formic acid and ACN (25: 75, v/v) and flow rate 1.2 ml/min (UV detection at 247 nm). Budesonide obeys Beer-Lambert’s law over a concentration range of 10-100 µg/ml. The linear regression equation was found to be y = 35317x + 3515.8 (r2 = 0.9999). The LOD and LOQ was found to be and 2.913 and 8.7643 µg/ml. Budesonide was subjected to forced degradation and the method was validated as per ICH guidelines.


Cite this article:
Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna, Rangisetty Spandana Yasaswini. New validated stability indicating RP-UFLC method for the determination of Budesonide. Research J. Pharm. and Tech 2020; 13(6): 2819-2824. doi: 10.5958/0974-360X.2020.00502.8

Cite(Electronic):
Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna, Rangisetty Spandana Yasaswini. New validated stability indicating RP-UFLC method for the determination of Budesonide. Research J. Pharm. and Tech 2020; 13(6): 2819-2824. doi: 10.5958/0974-360X.2020.00502.8   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-52


REFERENCES:
1.    Christophi GP, Rengarajan A and Ciorba MA. Rectal Budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach. Clinical and Experimental Gastroenterology. 2016; 9: 125-130.
2.    Stanaland BE. Once-daily Budesonide aqueous nasal spray for allergic rhinitis: A review. Clinical Therapeutics. 2004; 26 (4): 473-492.
3.    Silverman J, Otley A. Budesonide in the treatment of inflammatory bowel disease. Expert Rev Clin Immunol. 2011; 7 (4): 419-428.
4.    Todd GR, Acerini CL, Buck JJ, Murphy NP, Ross-Russell R, Warner JT, McCance DR. Acute Adrenal Crisis in Asthmatics Treated With High-Dose Fluticasone Propionate. Eur Respir J. 2002; 19 (6): 1207-1209.
5.    O'Donnell S and O'Morain CA: Therapeutic benefits of Budesonide in gastroenterology. Ther Adv Chronic Dis. 2010; 1(4):177-186.
6.    Ellul-Micallef R, Hansson E, Johansson SA: Budesonide: a new corticosteroid in bronchial asthma. Eur J Respir Dis. 1980; 61(3):167-173.
7.    Shuguang Hou, Michael Hindle, Peter RByron. A stability-indicating HPLC assay method for Budesonide. J Pharm Biomed Anal. 2001; 24(3): 371-380.
8.    Sonali RN and Amrita NB. Development of a validated specific HPLC method for Budesonide and characterization of its alkali degradation product. Canadian Journal of Analytical Sciences and Spectroscopy. 2008; 53(3): 113-122.
9.    Mukur Gupta and Hridaya NB. Development and validation of a high-performance liquid chromatographic method for the analysis of Budesonide. Journal of Pharmaceutical and Biomedical Analysis. 2006; 40(2): 423-428.
10.    Raveendra Babu Gudimitla, Lakshmana Rao Atmakuri , Venkateswara Rao Jangala. A novel method for the estimation of Budesonide in human plasma by using LC-MSMS. Der Pharma Chemica, 2018: 10(4): 181-185.
11.    ICH Validation of analytical procedures: Text and methodology Q2 (R1), International Conference on Harmonization (2005).
12.    ICH Stability Testing of New Drug Substances and Products Q1A (R2), International Conference on Harmonization (2003).

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): Shyama S. Kumar, Divya Bhosle, Akshay Janghel, Shraddha Deo, Parijeeta Raut, Chetan Verma, Mukta Agrawal, Nisha Amit, Mukesh Sharma, Tapan Giri, D. K. Tripathi1, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2015.00099.2         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Prabhakar Panzade, Prashant K Puranik

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vijaykumar T. Pawar, Shubhangi V. Pawar, Harinath N. More, Anita S. Kulkarni, Dinanath T. Gaikwad

DOI: 10.5958/0974-360X.2017.00724.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags