Author(s):
M. Poojitha, Saravana Kumar. A. S, S. V. Satya Narayana
Email(s):
poojithamallapu91@gmail.com
DOI:
10.5958/0974-360X.2020.00494.1
Address:
M. Poojitha1, Saravana Kumar. A. S2, S. V. Satya Narayana3
1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
2Department of Pharmacology, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh, India.
3Department of Chemical Engineering, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 6,
Year - 2020
ABSTRACT:
In the present study the medicinal plant named Chloris paraguaiensis Steud was used to evaluate the gastro protective effect. The whole plant was shade dried and used for experimental study which was designed on four different models of induced gastric ulcers. This showed the dose dependent gastro protection that was compared to the omeprazole 20mg/kg/B.w (Standard Drug). Different parameters like GSH (µg/mg protein), ALP (IU/L), Gastric volume (ml/100g), pH (Unit) were estimated, which has shown significant results when compared to the standard drug.
Cite this article:
M. Poojitha, Saravana Kumar. A. S, S. V. Satya Narayana. Gastroprotective Effect of Chloris paraguaiensis Steud Plant Extract in Various Experimental Models. Research J. Pharm. and Tech 2020; 13(6): 2784-2786. doi: 10.5958/0974-360X.2020.00494.1
Cite(Electronic):
M. Poojitha, Saravana Kumar. A. S, S. V. Satya Narayana. Gastroprotective Effect of Chloris paraguaiensis Steud Plant Extract in Various Experimental Models. Research J. Pharm. and Tech 2020; 13(6): 2784-2786. doi: 10.5958/0974-360X.2020.00494.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-44
REFERENCES:
1. Antonio JM, Geacioso JS, Toma W, Lopez LC, Oliveira F, Souza Brito ARM, “Antiulcerogenic activity of ethanol extract of Solanum variabile”. Journal of Ethnopharmacology. 2004: 93, 83–88.
2. Baggio CH, Freitas CS, Rieck L and.Margues MCA, “Gastroprotective effects of a crude extract of Baccharis illinita DC in rats”. Pharmacological Research. 2003:47, 93-98.
3. Chiang YM, Chang JY, Kuo CC, Chang CY and Kuo YH, “Cytotoxic triterpenes from aerial roots of Ficus microcarpa”. Phytochemistry. 2005:66: 495-501.
4. Cho CH and Ogle CW, “Cholinergic-mediated gastric mast cell degranulation with subsequent histamine H1 and H2-receptor activation in stress ulceration in rats. European”, Journal of Pharmacology. 1979: 55, 23-33.
5. Cho CH, Ogle CW and Dai S, “Acute gastric ulcer formation response to electrical vagal stimulation in rats”, European Journal of Pharmacology. 1976:35, 215-219.
6. Danielson G, Norgren L, Truedsson L, Andreasson A, Danielson P, Nilsson A, Swartbol P, “Flavonoïd treatment in patients with healed venons ulcer: flowcytometry analysis suggest increasedCD11b expression on neutrophil granulocyts in the circulation”, Vascular Medicine. 2003:8, 83–88.
7. Fellenius E, Berglindh T, Sachs G, Olbe L, Elander B, Sjostrand SE, Wallmark B. “Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+/K+) ATPase”, Nature, 1981:290, 159–161.
8. Flemstrom G, Garner A, Nylander O, Hurstt BC, Heyling JR, “Surface epithelial HCO3 transport by mammalian duodenum in vivo”American Journal of Physiology (Gastrointestinal, Liver Physiologie).,1982: 243, G 48–G 358.
9. Grijalva CV, Novin D,”The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology”, Annual New York Academic Sciences. 1990: 597, 207–222.
10. Gupta MB, Nath R, Gupta GP, Bhargava KP, “A study of the antiulcer activity of diazepam and other tranquillose datives in albino rats”,Clinical and Experimental Pharmacology, 1985:12, 61–63.