Author(s): D. Jesudurai, R. Monika

Email(s): ,

DOI: 10.5958/0974-360X.2020.00471.0   

Address: D. Jesudurai*, R. Monika
Department of Chemistry, School of Basic Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020

A green methodology was adopted for the preparation of silver nanoparticles. The leaves of Bael Tree (Aegle Marmelos) were possessed from the area of Redhills, Chennai, Tamil Nadu, India. From the clean and dried leaves, the Bael tree leave extract was obtained by a simple chemical process. This extract was further employed for the green synthesis of silver nanoparticles. When the extract was added into the colourless silver nitrate solution and stirred, a periodic colour change was observed indicates the formation of silver nanoparticles. Besides, Multiwalled Carbon Nanotubes (MWCNTs) were synthesized by a simple chemical approach using potassium persulphate as the solid oxidant. The synthesis of MWCNTs involves both the Conc. Sulphuric acid and Conc. Nitric acid were added to 99.9% pure graphite powder slowly with stirring for a period of 30 min. The solid oxidizing agent potassium persulphate was then added with stirring and the whole reaction mixture was refluxed to get the MWCNTs. The target Silver-doped multiwalled carbon nanotubes were produced by thermal treatment of the reaction mixture containing silver nanoparticles and MWCNTs. The antibacterial utility of the synthesized silver-doped MWCNTs was tested on different bacterial culture using Well diffusion method. The bacterial cultures employed for the anti-bacterial study are Enterococcus faecalis (MTCC 2729) and Pseudomonas aeruginosa (MTCC 424). The antibacterial investigation furnished that the Silver-doped carbon nanotubes exhibit good antibacterial activity. A higher antibacterial behavior was noticed on Pseudomonas aeruginosa than Enterococcus faecalis upon acted by silver-doped MWCNTs.

Cite this article:
D. Jesudurai, R. Monika. Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility. Research J. Pharm. and Tech 2020; 13(6):2653-2657. doi: 10.5958/0974-360X.2020.00471.0

D. Jesudurai, R. Monika. Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility. Research J. Pharm. and Tech 2020; 13(6):2653-2657. doi: 10.5958/0974-360X.2020.00471.0   Available on:

1.    Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI and Radomski MW. Nanoparticles: pharmacological and toxicological significance. British Journal of Pharmacology. 2007; 150(5): 552-558.
2.    Singh R and Lillard JW Jr, Nanoparticle-based targeted drug delivery. Experimental and Molecular Pathology. 2009; 86(3): 215-223.
3.    Lu K. Nanoparticulate Materials: Synthesis Characterization, and Processing, John Wiley and Sons, 2013.
4.    Oliveira ON Jr, Lost RM, Siqueira JR Jr, Crespilho FN and Caseli L. Nanomaterials for diagnosis: Challenges and applications in smart devices based on molecular recognition. ACS Applied Materials and Interfaces. 2014; 6(17): 14745-14766.
5.    Quesada-Gonzalez D and Merkoci A. Nanomaterial-based devices for point-of-care diagnostic applications. Chemical Society Reviews. 2018; 47(13): 4697-4709.
6.    Chernousova S and Epple M. Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal, Angewandte Chemie International Edition. 2013;   52(6): 1636-1653.
7.    Praetorius NP and Mandal, TK. Engineered Nanoparticles in Cancer Therapy, Recent Patents on Drug Delivery and Formulation. 2007; 1(1): 37-51.
8.    Kim CK, Ghosh P, Pagliuca C, Zhu Z-J, Menichetti S and Rotello VM. Entrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer Cells, Journal of the American Chemical Society. 2009; 131(4): 1360-1361.
9.    Moyano DF and Rotello VM. Nano meets Biology: Structure and Function at the Nanoparticle Interface, Langmuir. 2011; 27(17): 10376-10385.
10.    Chaudhuri RG and Paria S. Core/Shell Nanoparticles: Classes, Properties, Synthesis, Mechanisms, Characterization, and Applications. Chemical Reviews. 2012; 112 (4): 2373-2433.
11.    Mody VV, Nounou MI and Bikram M. Novel nanomedicine-based MRI contrast agents for gynecological malignancies. Advanced Drug Delivery Reviews. 2009; 61(10): 795-807.
12.    Gurunathan S, Park JH, Han JW and Kim J-H. Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: Targeting p53 for anticancer therapy. International Journal of Nanomedicine. 2015; 10(1): 4203–4223.
13.    Li WR, Xie XB, Shi QS, Zeng HY, Ou-Yang YS and Chen YB. Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli. Applied Microbiology and Biotechnology. 2010; 85(4): 1115-1122.
14.    Mukherjee P, Ahmad A, Mandal D, Senapati S, Sanikar SR, Khan MI, Parishcha R,  Ajaykumar PV, Alam M, Kumar R, and Sastry M. Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: A novel biological approach to nanoparticle synthesis. Nano Letters. 2001; 1(10): 515-519.
15.    Zottel A, Paska AV and Jovcevska I, Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy. Materials. 2019; 12: 1588.
16.    Hernandez-Arteaga A, Nava JZ, Kolosovas-Machuca ES, Velazquez-Salazar JJ, Vinogradova E, Jose-Yacaman M and Navarro-Contreras HR.  Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles,  Nano Research, 2017; 10(11): 3662-3670.
17.    Bhattacharyya S, Kudgus RA, Bhattacharya R and Mukherjee P. Inorganic Nanoparticles in Cancer Therapy, Pharmaceutical Research, 2011; 28(2): 237-259.
18.    Alexander JW. History of the Medical Use of Silver. Surgical Infections, 2009; 10(3):  289-292.
19.    Larrude DG, Maia da Costa MEH and Freire FL Jr. Synthesis and Characterization of Silver Nanoparticle-Multiwalled Carbon Nanotube Composites. Journal of Nanomaterials. 2014; 654068.
20.    Patel PK, Sahu J, Sahu L, Prajapati NK and Dubey BK. Aegle marmelos: A Review on its Medicinal Properties. International Journal of Pharmaceutical and Phytopharmacological Research. 2012; 1(5): 332-341.
21.    Patkar AN, Desai NV, Ranage AA and Kalekar KS. A Review on Aegle marmelos: A Potential Medicinal Tree. International Research Journal of Pharmacy. 2012; 3(8): 86-91.
22.     Rani VSV, Arun K, Dhanasekaran T, Narayanan V and Jesudurai D. Amperometric nanomolar detection of dopamine using metal free carbon nanotubes synthesized by a simple chemical approach. Materials Research Express. 2018; 5: 95604.   
23.    Behravan M, Panahi AH, Naghizadeh A, Ziaee M, Mahdavi R and Mirzapour A. Facile green synthesis of silver nanoparticles using Berberis vulgaris leaf and root aqueous extract and its antibacterial activity. International Journal of Biological Macromolecules. 2019; 124: 148-154.
24.  Das R, Bee SAH,  Eaqub MA, Ramakrishna S and   Yongzhi W. Carbon Nanotubes Characterization by X-ray Powder Diffraction – A Review. Current Nanoscience. 2015; 11(1): 23-35.

Recomonded Articles:

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): Arvindganth. R, Anupriya K.V., Kathiravan. G

DOI: 10.5958/0974-360X.2017.00105.6         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): S. Krishnakumar, R. Divya, N.R. Kanchana Devi, G. Keerthana, A. Ancy Judi

DOI: 10.5958/0974-360X.2017.00234.7         Access: Open Access Read More

Author(s): Prativa Biswasroy, Sthitapragnya Panda, Debajyoti Das, Durga Madhab Kar, Goutam Ghosh

DOI: 10.5958/0974-360X.2020.00090.6         Access: Open Access Read More

Author(s): Saba Shaikh, Ravi Dubey, Swati Dhande, Y.M Joshi, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Iffath Badsha, Valli Nachiyar C

DOI: 10.5958/0974-360X.2017.00688.6         Access: Open Access Read More

Author(s): Pooja Kumari, Umakant, Gyanendra Sharma

DOI: 10.5958/0974-360X.2020.00462.X         Access: Open Access Read More

Author(s): A. Elayaraja, G. Devala Rao

DOI:         Access: Open Access Read More

Author(s): K. Girija, S. Karthika, Nisha Mathew

DOI: Not Available         Access: Open Access Read More

Author(s): Perumal Andal, S. Tamilselvy, P. Indra Priyatharesini

DOI: 10.5958/0974-360X.2018.00509.7         Access: Open Access Read More

Author(s): Sree Vidhya T.M., Geetha

DOI: Not Available         Access: Open Access Read More

Author(s): Kumudhaveni B, Radha R, Jiyavutheen M, Kavithasai M, Kowsalya J

DOI: 10.5958/0974-360X.2020.00185.7         Access: Open Access Read More

Author(s): Cut Aja Nuraskin, Marlina, Rinaldi Idroes, Cut Soraya, Djufri

DOI: 10.5958/0974-360X.2019.01048.5         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles