Author(s):
Pooja Kumari, Umakant, Gyanendra Sharma
Email(s):
kr.pooja007@gmail.com
DOI:
10.5958/0974-360X.2020.00462.X 
Address:
Pooja Kumari*, Umakant, Gyanendra Sharma
Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, N.H. #2, Mathura Delhi Road, P.O. chhatikara, Mathura, Uttar Pradesh (INDIA) 281001.
*Corresponding Author
Published In:
Volume - 13,
Issue - 6,
Year - 2020
ABSTRACT:
A series of some newer benzimidazole derivatives were synthesized and evaluated for their anti-bacterial activity. Some of new benzimidazole derivatives are derived from the parent compound. The result shows all the compounds have low micromoler minimal inhibitory concentration (MIC) gives a good antibacterial activity against Gram-positive or Gram-negative bacteria. Benzimidazole is the heterocyclic compound formed from benzene ring and five-member ring containing nitrogen and its derivatives are wide interest because of their diverse biological activity and clinical applications.
Cite this article:
Pooja Kumari, Umakant, Gyanendra Sharma. Synthesis and Antibacterial activity of some newer Benzimidazole derivatives. Research J. Pharm. and Tech 2020; 13(6):2597-2600. doi: 10.5958/0974-360X.2020.00462.X
Cite(Electronic):
Pooja Kumari, Umakant, Gyanendra Sharma. Synthesis and Antibacterial activity of some newer Benzimidazole derivatives. Research J. Pharm. and Tech 2020; 13(6):2597-2600. doi: 10.5958/0974-360X.2020.00462.X Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-6-12
REFRENCE:
1. Himaja M., Rajiv and Ramana M.V. ‘synthesis of 6-Nitrobenzimidazol-1-acetyl amino acids and peptides as potent anthelmintic agents’, Indian J. Heterocycl. Chem., 2002, Vol. 12, pp. 121-124
2. Tuncbilek M., Kiper T. and Altanlar N. ‘Syntheis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA’, Eur. J. Med. Chem., 2009 Vol. 44, pp. 1024-1033.
3. National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina: NTP
4. Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 79th ed. Boca Raton, FL: CRC Press Inc., 1998-1999., p. 3-6
5. Bhatnagar I and George MV, Tetrahedron,1968, 24,1293.
6. Goodman LA, et al. Preliminary investigations on the pharmacology of benzimidazole. Fed Proc 1943; 2:1. 2.
7. Woolley DW. Some biological effects produced by benzimidazole and their reversal by purines. J Biol Chem 1944; 152:225
8. Saikat Kumar Poddar, Nazam Saqueeb. S.M. Abdur Rahman “synthesis and biological evaluation of 2-methyl-1 H-enzzimidazole and 1H-benzimidazole-2-yl-methanol” Dhaka univ.J.Pharm.Sci.15(1); 83-87, 2016
9. Sharma C. Mukesh, Dharm V.Kohli, Smita Sharma Synthesis and biological evaluation of some new benzimidazole derivatives 4-{5-amino-2-[-2-substituted-phenylamino0)-phenyl-methyl]-benzimidazole-1yl methyl}-biphenyl-2-carboxylic acid: nanopeptide angiotension II receptor antagonists” internation journal of drug delivery 2 (2010) 265-277
10. R. Singla et. al. Europian journal of medicinal chemistry 146 (2018) 206-219
11. Mall Rajib, Singh Gagandeep, Singh amanjot, Synthesis biological and molecular docking studies of novel benzimidazole derivatives” computer biology and chemistry (2017)