ABSTRACT:
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. The pharmacotherapy of diabetes includes use of oral hypoglycaemic agents like insulin and oral hypoglycaemic agents such as biguanides, sulphonylureas, insulin analogues, alpha glucosidase and amylse inhibitors, gliptins etc. Though these agents are therapeutically beneficial, they are associated with adverse effects such as hypoglycaemia, vitamin B12 deficiency, weight gain, etc. The alternatives as herbs and/or phytoconstituents, exercise, yoga, etc have been explored widely for treatment and management of diabetes mellitus. Number of plants and their isolated phytoconstituents are proven for antidiabetic activity in preclinical and clinical studies and one of widely explored of them is Curcumin. The Curcumin in its nanoparicles form had been already proven for potential antidiabetic activity. Though the phytoconstituents are said to be safe their interactions with modern medicines might be either beneficial or harmful and should be considered while co-administration of them. This research work focuses on evaluation of drug interaction between CuNPs and Metformin in STZ-Nicotinamide induced hyperglycemia in Wistar rats. The physical incompatibility between curcumin and metformin was not observed in the study. The coadministration of both produced significant reduction in glycemic and oxidative parameters than only metformin treated animals. The study suggest coadministration of curcumin and metformin can be used for better and safe management and treatment of diabetes mellitus.