Author(s): Inshah Ahmed, Nishat Ahmed, Saleha Ahmed, Fazil Ahmad, Abeer Mohammed Al-Subaie

Email(s): amnalsubaie@iau.edu.sa

DOI: 10.5958/0974-360X.2020.00451.5   

Address: Inshah Ahmed1, Nishat Ahmed2, Saleha Ahmed3, Dr. Fazil Ahmad4, Dr. Abeer Mohammed Al-Subaie5
1Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist) - 508284, Telangana, India.
2M. Pharm., Pharmacology, Lecturer, Taibah University, Janadah Bin Umayyah Road, Tayba, Madinah Al-Munawwarah - 42353, Saudi Arabia.
3Department of Pharmaceutics, MRM College of Pharmacy, Hyderabad, 501510, Telangana, India.
4Assistant Professor, Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University - Dammam, Jubail 35816, Saudi Arabia.
5Assistant Professor of Haematology, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences , Imam Abdul Rahman Bin Faisal University, P.O.Box-1982 - Dammam, Saudi Arabia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020


ABSTRACT:
Background: Currently natural products are of great interest in drug discovery. Natural products contains novel molecules that are been developed as potent therapeutic agents. Fibrosis is the most common disease observed in females. Emblica officinalis (Amla) is the most traditional agent used from decades and lot of research is going on to explore its therapeutic efficacy. Objective: The objective of present study is to evaluate the effect of Emblica officinalis(Amla) on Monosodium Glutamate (MSG) induced uterine fibroids in wistar rats. Method: Twenty four female wistar rats weighing 180-300g were divided into group of four. Group A was the no treatment group (Control). Groups B and C and D were treated with Monosodium glutamate (inducer), Emblica officinalis (test drug) and combined contraceptive pill (Standard drug). Treatment with MSG was conducted for 30 days followed by Amla after which total protein, plasma cholesterol and estradiol were determined. The animals in group is in control receives of 5.0ml distilled water via gastric incubation. And in another groups of 2 and 3 the animals treated with 100mg MSG/Kg with combination of 10 mg/kg Amla and in a total volume of 5.0 ml vehicle. Where, however the animals were treated with MSG only for 30 day before the commencement of treatment with Emblica officinalis (Amla) extracts and these experiment lasted for 60 days. Result: Results demonstrated that the level of estradiol, cholesterol and total serum protein level was ameliorated indicating anti-fibrotic effect of Emblica officinalis. Interpretation and Conclusion: Emblica officinalis contains uterine fibroid protective phytochemicals and may be useful in preventing uterine fibroids induced by MSG. This activity can be attributed to phenolic and other constituents and one of the mechanisms could be by balancing of oxidative stress, acting as anti-oxidant.


Cite this article:
Inshah Ahmed, Nishat Ahmed, Saleha Ahmed, Fazil Ahmad, Abeer Mohammed Al-Subaie. Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats. Research J. Pharm. and Tech 2020; 13(6):2535-2539. doi: 10.5958/0974-360X.2020.00451.5


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1.      Abdel-Rahman MY, Sabry M, Al-Hendy A. Medical Treatment of Fibroid to Decrease Rate of Hysterectomy. In: Al-Hendy A, editor. Hysterectomy. Rejeka: InTech; 2012. pp. 115–128.

2.      Andersen J. Growth factors and cytokines in uterine leiomyomas. Semin Reprod Endocrinol. 1996; 14(3):269–282.

3.      Antioxidant activity of the fruit and the Ayurvedic preparation of Emblica officinalis Gaertn. Journal of Ethnopharmacology. 2006; 104:113–118.

4.      Baird DD, Dunson DB. Why is parity protective for uterine fibroids? Epidemiology. 2003; 14(2):247–250.

5.      Baird DD, Kesner JS, Dunson DB. Luteinizing hormone in premeno-pausal women may stimulate uterine leiomyomata development. J Soc Gynecol Investig. 2006; 13(2):130–135.

6.      Bajracharya MB, Ayurvedic Medicinal Plants. Kathmandu; Piyusavarsi Ausadhalaya,1979.

7.      Ball P, Woodward D, Beard T, Shoobridge A, Ferrier M. Sponsorship: We acknowledge the financial support of the International Glutamate Technical Committee (IGTC), a nongovernmental organization funded by industrial producers and users of glutamate in food. (June 2002). "Calcium diglutamate improves taste characteristics of lower-salt soup". Eur J Clin Nutr. 56 (6): 519–23. PMID 12032651. doi:10.1038/sj.ejcn.1601343.

8.      Bozzini N, Rodrigues CJ, Petti DA, et al. Effects of treatment with gonadotropin releasing hormone agonist on the uterine leiomyomata structure. Acta Obstet Gynecol Scand. 2003; 82:330–334.

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