ABSTRACT:
Background: Currently natural products are of great interest in drug discovery. Natural products contains novel molecules that are been developed as potent therapeutic agents. Fibrosis is the most common disease observed in females. Emblica officinalis (Amla) is the most traditional agent used from decades and lot of research is going on to explore its therapeutic efficacy. Objective: The objective of present study is to evaluate the effect of Emblica officinalis(Amla) on Monosodium Glutamate (MSG) induced uterine fibroids in wistar rats. Method: Twenty four female wistar rats weighing 180-300g were divided into group of four. Group A was the no treatment group (Control). Groups B and C and D were treated with Monosodium glutamate (inducer), Emblica officinalis (test drug) and combined contraceptive pill (Standard drug). Treatment with MSG was conducted for 30 days followed by Amla after which total protein, plasma cholesterol and estradiol were determined. The animals in group is in control receives of 5.0ml distilled water via gastric incubation. And in another groups of 2 and 3 the animals treated with 100mg MSG/Kg with combination of 10 mg/kg Amla and in a total volume of 5.0 ml vehicle. Where, however the animals were treated with MSG only for 30 day before the commencement of treatment with Emblica officinalis (Amla) extracts and these experiment lasted for 60 days. Result: Results demonstrated that the level of estradiol, cholesterol and total serum protein level was ameliorated indicating anti-fibrotic effect of Emblica officinalis. Interpretation and Conclusion: Emblica officinalis contains uterine fibroid protective phytochemicals and may be useful in preventing uterine fibroids induced by MSG. This activity can be attributed to phenolic and other constituents and one of the mechanisms could be by balancing of oxidative stress, acting as anti-oxidant.