Author(s): Vishali T, Damodharan N

Email(s): damodhan@srmist.edu.in

DOI: 10.5958/0974-360X.2020.00449.7   

Address: Vishali T, Damodharan N*
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
In the pharmaceutical industry oral route is considered as the safest and convenient route. Orodispersible tablets (ODTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving an easy to swallow residue. These dosage form contains superdisintegrants which imparts quick disintegration with presence of saliva and can be swallowed easily. ODTs are the very good choice for the pediatric and geriatric patients. To improve the bioavailability of many drugs, orodispersible drug delivery systems are used extensively. Advanced technologies used for manufacturing orodispersible tablets are by direct compression method, freeze drying method, sublimation method, mass extrusion and cotton candy process. Taste is the important factor because these tablets disintegrate directly in the mouth. ODTs are evaluated by following parameters like hardness test, friability test, disintegration test and dissolution test. Many technologies are introduced for producing controlled release orodispersible tablets which broadens the applications of this dosage form. These tablets are also known as mouth dissolving tablets and fast dissolving tablets. In this review article we can focus on ideal properties, challenges, advantages, disadvantages, conventional techniques, patented technologies and evaluation of orodispersible tablets.


Cite this article:
Vishali T, Damodharan N. Orodispersible Tablets: A Review. Research J. Pharm. and Tech 2020; 13(5): 2522-2529. doi: 10.5958/0974-360X.2020.00449.7

Cite(Electronic):
Vishali T, Damodharan N. Orodispersible Tablets: A Review. Research J. Pharm. and Tech 2020; 13(5): 2522-2529. doi: 10.5958/0974-360X.2020.00449.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-79


REFERENCES:
1.    Valleri M, Mura P, Maestrelli F, Cirri M, Ballerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique. Drug Dev Ind Pharm 2004; 30(5): 525-534.
2.    Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP, Mastiholimath VS. Orodispersible tablets: New-fangled drug delivery systems – A review. Indian J Pharm Educ Res 2005; 39(4):177-81.
3.    Seager H. Drug-delivery products and the Zydis fast-dissolving dosage form. J Pharm Pharmacol 1998; 50(4): 375-82.
4.    Bradoo R, Shahani S, Deewan B, Sudarshan S. Fast dissolving drug delivery system. J Am Med Assoc India 2001;4(10): 27-31.
5.    Parakh SR, Gothoskar AV (2003). A review of mouth dissolving tablet technologies. Pharm Tech 27: 92-98.
6.    Kaushik D, Dureja H, Saini TR. Mouth dissolving tablets: A Review. Indian Drugs 2004; 41 (4): 187-193.
7.    Tanmoy G, Amitava G and Devi P: A review on new generation orodispersible tablet and its future prospective. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3: 1-7.
8.    Hirani JJ, Rathod DA and Vadalia KR: Orally Disintegrating Tablets: A Review. Tropical Journal of Pharmaceutical Research 2008; 8(2): 161-172.
9.    Arora P, Arora VS: Orodispersible tablets: A comprehensive review. International Journal of Research and Development in Pharmacy and Life Sciences 2013; 2: 270-284.
10.    Mudgal V.K, Singhai A.K, Orally Disintegrating tablet: A Review.International Research Journal of Pharmacy 2011; ISSN 2230-8407.
11.    Rahul C, Zahra H, Farhan A, Alan MS, Afzal RM. The role of formulation excipients in the development of Lyophilised fast - disintegrating tablets. Eur. J. Pharm. Biopharm.2009;72:119-229.
12.    Jain D, Amul M (2014) A Review - Formulation & Development of Orodispersible Tablet. Int J Pharm Eru 4: 21-38.
13.    Deepak K, Orally disintegrating tablets. Tablets and Capsules, 2004; 7: 30-35.
14.    Tarique Khan, Sayyed Nazim,Siraj Shaikh,Afsar Shaikh,Ashish Khairnar, Aejaz Ahmed. An approach for rapid disintegrating tablet: a review: 2011;3(3): 170 – 183.
15.    Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patent 5,1994; 298, 261.
16.    Deepak H, Geeta A, Hari Kumar SL. Recent trends of fast dissolving drug delivery system - An overview of formulation technology. Pharmacophore 2013;4(1):1-9.
17.    Bangale GS, Yadav GJ, Shinde GV and Stephen Rathinaraj B: New Generation of Orodispersible Tablets: Recent Advances and Future Prospects. International Journal of Pharmacy and Pharmaceutical Science Research 2011; 1(2): 52-62.
18.    Harsoliya MS, Pathan JK and Shruti S: A Review Formulation of Mouth Dissolving tablet.International Journal of Pharmaceutical and Clinical Science 2011; 1(1): 1-8.
19.    Mishra DN, Bimodal M, Singh SK, Vijaya Kumar SG (2006) Spray dried excipient base: a novel technique for the formulation of orally disintegratinuhg tablets. Chem Pharm Bull 54(1): 99-102
20.    Debit Bhowmik, B. Jayakar, K. Sampath Kumar. Fast dissolving drug delivery system; International Journal of Pharma Research 2009,1(1),31 40.
21.    Mahapatra AK, Swain RP, Revathi B, Nirisha N, Murthy PN. Orodispersible tablets: A review on formulation development technologiesand strategies. Res J Pharm Technol. 2013;6(9):941–53.
22.    Jaybhaye Aarti, Joshi Sonali, Deshmukh Ganesh Orodispersible Tablets: A Comprehensive Review.
23.    .Giri T, Tripathi D, Majumdar R. Orodispersible Tablets: An Overview of Tastemasking and Evaluation Techniques. Res J Pharm Dos Form Technol. 2010;2(3):225–32.
24.    Baghel P, Roy A, Chandrakar S, Bahadur S. Fast Dissolving Drug Delivery Systems: A Brief Review. Res J Pharm Technol. 2013; 6(6): 597602.
25.    Deshpande KB, Ganesh NS. Orodispersible tablets: An overview of formulation and technology. Int J Pharm Biol Sci 2011;2(1):726-34.
26.    Kumar E, Bhagyashree J. Mouth dissolving tablets – A comprehensive review. Int J Pharm Res Rev 2013;2(7):25-41.
27.    Chiman B, Isha S. Development of fast disintegration tablets as oral drug delivery system - A review. Indian J Pharm Biol Res 2013;1(3):80 99.
28.    Wilson CG, Washington N, Peach J, Murray GR, Kennerley J. The behavior of a fast dissolving dosage form (Expidet) followed by G-Scintigraphy. Int J Pharm 1987; 40: 119–123.
29.    Fix JA. Advances in quick-dissolving tablets technology employing Wowtab. Paper Presented at: IIR Conference on Drug Delivery Systems. 1998; Washington DC, USA.
30.    Shukla D, Chakraborty S, Singh S, Mishra B. Mouth Dissolving Tablets I:An Overview of Formulation Technology. Scientia Pharmaceutica Sci Pharm 2009; 77: 309–326.
31.    Pranjal Jain, Shriya Jain, Ashwani Mishra and Anupam Pathak A Review on Orodispersible Tablet
32.    Kumar R., Patil M.B., Patil S.R., Paschpura M.S. Development & characterization of melt-in-tablets of Haloperidol by sublimation technique. Int J Pharm Pharm Sci 2009; 1(1): 65-73.
33.    Patel P, Tanwar YS, Jaimin M and Patel A: Orodispersible Tablet of Proton Pump Inhibitor Drugs: A Review. Journal of Pharmaceutical Science and Bioscientific Research 2013; 3(2): 68-76.
34.    Velmurugan S, Sundar V: Oral Disintegrating Tablets: An Overview. International Journal of Chemical and Pharmaceutical Sciences 2010; 1(2): 1-12.
35.    Gupta A, Mishra AK, Gupta V, Bansal P, Singh R, Singh AK. Recent trends of fast dissolving tablet - An overview of formulation technology. Int J Pharm Biol Arch 2010;1(1):1-10.
36.    Mansing G. Patil, Suhas M. Kakade and Sandhya G.Pathade (2011). Formulation and evaluation of orally disintegrating tablet containing tramadol hydrochloride by mass extrusion technique. Journal of Applied Pharmaceutical Science 01(06): 178-181.
37.    Kumar NP, Nayyar P, Kumar SP. Fast dissolving tablets - A review. Middle East J Sci Res 2015;23(1):142-8.
38.    Reddy L.H., Ghosh B., Rajneesh (2002) Fast dissolving drug delivery systems: a review of the literature. Indian J. Pharm. Sci. 64(4): 331-336.
39.    P.B. Patil, V. N. More, N.S. Tour Recent Trends in Orodispersible Tablets – An Overview of Formulation Technology and Future Prospects.
40.    Aarti J, Sonali J, Ganesh D. Orodispersible tablets: A comprehensive review. Res J   Pharm Technol. 2014;7(3):368–75
41.    More SA et al. Orodispersible Tablet- A Novel Drug Delivery System. J Pharm Sci Tech 2012; 4 (1): 798 -806.
42.    Yoshio K, Masazumi K, Shuichi A, Hiroaki N. Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. J Control Release 2005;105 (1-2): 16-22.
43.    Mohan SC, Margret CR: Recent advances in orodispersible tablets: A Review. International Journal of Drug Discovery and Herbal Research 2011; 1(2): 78-83.
44.    Mohit M, Sunil T, Manish G, Pankaj G. Super disintegrants: An updated review. Int J Pharm Pharm Sci Res 2012;2(2):26-35.
45.    Lachmann L., Liebermann H. A. and Kiang J.L., The theory and practice of Industrial Pharmacy, Varghese Publishing House, Bombay, 3 rd ed. 1998.
46.    Tablets Formulation of tablets/ Disintegration. www.pharmpedia.com,2006.
47.    Shah U. and Augsburger L., Evaluation of the functional equivalence of crospovidone NF.
48.    Ravi, Geeta Rajput, Amit Kumar A Review Article on Orodispersible tablet Formulation..
49.    Sagar N, Goswami L, Kothiyal P. Orally disintegrating tablets: A review. Int J Adv Pharm Res 2012;3(10):1222-8.
50.    Sachin Gholve, Amar Kaware, Sanjay Thonte, Dattahari Kaudewar and Omprakash Bhusnure. Orodispersible Tablets: A Systematic Review.
51.    P.Venkateshwar Reddy, Swagata Dutta Roy, G.Vasavi, N.Sriram Department of Pharmaceutics, Oral Dispersible Tablets - A Review.
52.    Badgujar BP, Mundada AS: The Technologies Used for Developing Orally.
53.    Swain RP, Satish P, Subudhi BB, Panda S. Formulation and optimization of Orodispersible tablets of ibuprofen. Int J Pharm Pharm Sci. 2015;7(2):441–7
54.    Virely P, Yarwood R. Zydis – A novel, fast dissolving dosage form. Manuf Chem 1990; 36-37.
55.    Srinivasa D, Charyulu NR, Satyanarayana D, Srilakshmi D. Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole. Res J Pharm Technol. 2015;8(10):1389.
56.    Bikshathi D, Saikrishna K, Ashok Kumar G. Sabitha G, Saikumar B. Fast dissolving tablets: An update. International Research Journal of Pharmacy.2011; 2:45-53.
57.    Patel P, Tanwar YS, Jaimin M and Patel A: Orodispersible Tablet of Proton Pump Inhibitor Drugs: A Review. Journal of Pharmaceutical Science and Bioscientific Research 2013; 3(2): 68-76.
58.    Chaudhari P.D., Chaudhari S.P., Lanke S.D. and Patel N.,( 2007)., Formulation and in vitro evaluation of teste masked orodispersible dosage form of Levocetirizine dihydrochloride; Indian Journal of Pharmacuitical Education and Research 41(4).,319-327 .
59.    Rangu N, Kumari BC, Akula G, Jaswanth A. Formulation and Evaluation of Metoprolol Orodispersible Tablets by Super Disintegration Method. Asian J Pharm Res. 2018;8(3):119.
60.    Mohire N, Yadav A, Gaikwad V. Novel Approaches in Development of Metronidazole Orodispersible Tablets. Res J Pharm Technol. 2009;2(2):283–6.
61.    Mandlik S, Nandare D, Joshi M, Chudiwal P, Jain K. Statistical Optimization of Orodispersible Tablets Containing Telmisartan Using Factorial Design and Response Surface Methodology. Res J Pharm Technol. 2009;2(3):548–51.
62.    Sanket K, Garg SK, Ajay A, Pradeep L. Fast dissolving tablets (FDTS): Recent trends and new market opportunities. Indo Am J Pharm Res 2014;4(7):3265-79.
63.    Rish RK. A review on fast dissolving tablets techniques. The Pharma Review 2004; 2: 32.
64.    Caramella C. Int J Pharm Techno Prod Mfr. 1984; 5:1‐5.
65.    Adel M, Semreen MK, Qato KM, et al. fast dissolving dosageforms‐.technique. Pharm Tech 2005; 2: 68‐75.
66.    Dobetti L. Fast‐ Melting Tablets: Developments and Technologies: Pharmaceutical Technology. Drug Delivery 2001 (Supplement): 44‐50.
67.    Allen LV, Wang B, Davis JD, et al. US patent 5,1998; 807, 567.
68.    Ghosh T, Ghosh A, Prasad D. A Review on New Generation Orodispersible Tablets and its future prospective. Int Journ Pharm Pharm Sci 2011.
69.    Deepika J, Mishra A. A review - Formulation and development of orodispersible tablet. Int J Pharm Erudition 2014;4(1):21-38.
70.    Kalpesh G, Lalit K, Kori M, Sharma C, Nema R. Formulation and charecterisation of fast dissolving tablet of Aceclofenac by sublimation method. International Journal of Pharmaceutical Science and Research.2011;3:19-22
71.    Daharwal S, Jangde R, Saraf S, Saraf S. Taste masking method for bitter drug and tasteless dispersible tablet: An overview. Famvita Net Journal. 2008:1‐3.
72.    Khairnar Dhiraj A., Anantwar Sanjay P., Chaudhari Chetan S., Valavi Ashish B. Orodispersible Tablets-An Overview Department of Pharmaceutics, MVP’s College of Pharmacy, Nashik. 422002 (MS) India.
73.    Nehal S, Garima G, Pramod S. Fast dissolving tablets: Preparation, charecterisation and evaluation: An overview. International Journal Of Pharmaceutical Sciences Review And Research.2010;4:87-96.
74.    Sharma K, Pfister WR and Ghosh TK: Quick-Dispersing Oral Drug Delivery Systems. Drug delivery to oral cavity. Taylor & Francis Group, LLC 2005: 261-290.

Recomonded Articles:

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Kishore Manoharan, Navya Ajitkumar Bhaskaran, Lalit Kumar

DOI: 10.5958/0974-360X.2019.01070.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags