Author(s): Alexander Patera Nugraha, Fianza Rezkita, Martining Shoffa Puspitaningrum, Mahela Sefrian Luthfimaidah, Ida Bagus Narmada, Chiquita Prahasanti, Diah Savitri Ernawati, Fedik Abdul Rantam

Email(s): alexander-patera-nugraha@fkg.unair.ac.id

DOI: 10.5958/0974-360X.2020.00446.1   

Address: Alexander Patera Nugraha1,2,3, Fianza Rezkita4, Martining Shoffa Puspitaningrum4, Mahela Sefrian Luthfimaidah4, Ida Bagus Narmada2, Chiquita Prahasanti5, Diah Savitri Ernawati6, Fedik Abdul Rantam7
1Bone and Tissue Engineering Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Orthodontics Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
3Doctoral Student of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
4Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
5Periodontology Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
6Oral Medicine Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
7Virology Laboratory, Microbiology Department, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
Periodontitis is a common chronic inflammatory disease in the periodontal tissue. In Indonesia, the prevalence of chronic periodontitis with alveolar bone defect ranging from 80%. Thus, definitive treatment of periodontitis is necessary. A combination of Chitosan Scaffold and Gingival Mesenchymal Stem Cell (GMSC) can be used as an alternative treatment. Chitosan scaffold is chosen because it is biocompatible, non-toxic good bio-mechanic properties and characterized as tissue engineering material. GMSC is chosen because it is easily isolated with minimal invasive method, it also possesses a multipotent differentiation of mesenchymal lineages, and it can accelerate bone remodeling in alveolar bone defect. This narrative review summarized the potential combination of GMSC and Chitosan scaffold to ameliorate alveolar bone defect in periodontitis. GMSC possesses an ability to differentiate into osteogenic lineage. The combination between chitosan scaffold/ and GMSCs may increase alveolar bone remodeling rate. The combination of GMSC and Chitosan scaffold can be a promising approach and therapy in alveolar bone defect due to periodontitis by accelerating alveolar bone remodeling.


Cite this article:
Alexander Patera Nugraha, Fianza Rezkita, Martining Shoffa Puspitaningrum, Mahela Sefrian Luthfimaidah, Ida Bagus Narmada, Chiquita Prahasanti, Diah Savitri Ernawati, Fedik Abdul Rantam. Gingival Mesenchymal Stem Cells and Chitosan Scaffold to Accelerate Alveolar Bone Remodelling in Periodontitis: A Narrative Review. Research J. Pharm. and Tech 2020; 13(5):2502-2506. doi: 10.5958/0974-360X.2020.00446.1

Cite(Electronic):
Alexander Patera Nugraha, Fianza Rezkita, Martining Shoffa Puspitaningrum, Mahela Sefrian Luthfimaidah, Ida Bagus Narmada, Chiquita Prahasanti, Diah Savitri Ernawati, Fedik Abdul Rantam. Gingival Mesenchymal Stem Cells and Chitosan Scaffold to Accelerate Alveolar Bone Remodelling in Periodontitis: A Narrative Review. Research J. Pharm. and Tech 2020; 13(5):2502-2506. doi: 10.5958/0974-360X.2020.00446.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-76


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