Author(s): Nawaz Mahammed, Harshini Yadav, Ashok Thulluru, Narahari Narayana, Saravanakumar, Anna Balaji, S. Mounika

Email(s): mounikamouni6390@gmail.com

DOI: 10.5958/0974-360X.2020.00435.7   

Address: Nawaz Mahammed1, Harshini Yadav1, Ashok Thulluru2, Narahari Narayana2, Saravanakumar2, Anna Balaji2, S. Mounika1
1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupati-517102, A.P., India.
2Centre for Pharmaceutical Research, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupati-517 102, A.P., India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
In the present study an effort was made to improve dissolution profile of clopidogrel bisulphate by formulating into liquisolid (LS) compact.PEG400 was taken as non volatile solvent in preparation of LS compacts. compatibility of excipients and drug was confirmed by FT-IR studies. The prepared powder blend is having good flow properties.The entrapment of drug within the excipients was confirmed by SEM studies. Disintegration time of LS compacts was decreased by the incorporation of super disintegrants (sodium starch glycolate and pvpk30).F2 formulation was chosen as best formulation based on dissolution and disintegration profiles. The release profile of F2 LS was compared with marketed product (plavix) and results revealed that, the dissolution of drug in LS compact was higher when compared with marketed product, may be due to presence of drug in non-volatile solvent PEG400.


Cite this article:
Nawaz Mahammed, Harshini Yadav, Ashok Thulluru, Narahari Narayana, Saravanakumar, Anna Balaji, S. Mounika. Formulation and Evaluation of Clopidogrel Bisulphate Tablets by Liquisolid Compact Technique. Research J. Pharm. and Tech 2020; 13(5):2427-2434. doi: 10.5958/0974-360X.2020.00435.7

Cite(Electronic):
Nawaz Mahammed, Harshini Yadav, Ashok Thulluru, Narahari Narayana, Saravanakumar, Anna Balaji, S. Mounika. Formulation and Evaluation of Clopidogrel Bisulphate Tablets by Liquisolid Compact Technique. Research J. Pharm. and Tech 2020; 13(5):2427-2434. doi: 10.5958/0974-360X.2020.00435.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-65


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