Design and Development of Pulsatile drug delivery of Diltiazem Hydrochloride

B. Vamsi Krishan; CH. Babu Rao; V. Sai Kishore

doi:10.5958/0974-360X.2020.00417.5

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Design and Development of Pulsatile drug delivery of Diltiazem Hydrochloride

Author(s): B. Vamsi Krishan, CH. Babu Rao, V. Sai Kishore

Email(s): vamsikrishan99@gmail.com

DOI: 10.5958/0974-360X.2020.00417.5

Address: B. Vamsi Krishan1*, CH. Babu Rao2, V. Sai Kishore3
1Research Scholar, Acharya Nagarjuna University, Nagarjunanagar-522510.
2Priyadarshini Institute of Pharmacy Education and Research, Guntur 522017.
3Department of Pharmaceutics, Bapatla College of Pharmacy. Guntur.
*Corresponding Author

Published In: Volume - 13, Issue - 5, Year - 2020

View HTML

Purchase PDF

ABSTRACT:
In the present study, an effort was made to develop a novel dosage form by using a chrono-pharmaceutical approach for the treatment of hypertension using Diltiazem hydrochloride as a model drug. A time delayed capsule was prepared by sealing the pellets inside the insoluble hard gelatin capsule body with erodible hydrogel plug. The pellets were prepared by emulsion Fluidized Bed Wurster (bottom spray) technology technique. Optimized pellets formulations were selected based on dissolution studies. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. Hydrogel plug (HPMCK4 and lactose in 1:1 ratio) having 4.5kg/cm2 hardness and 100 mg weight was placed in the capsule opening and found that it was suitable to avoid the drug release in small intestinal fluid and to eject out the plug in colonic fluid and releasing the pellets into colonic fluid after a lag time criterion of 5 hours. In order to simulate the pH changes along the GI tract, three dissolution media with pH 1.2, 7.4 and 6.8 were successively used. FTIR study confirmed that there was no interaction between drug and polymer. Among all the formulations Diltiazem hydrochloride pellets coated with Eudragit FS 30D in 35% w/w concentrations shown prolonged release for a period of 12 hours. The obtained results revealed the capability of the system in delaying drug release for a programmable period of time and can prevent a sharp increase in the incidence of blood pressure, during the early morning hours, a time when the risk of hypertension attacks is the maximum.

Keywords:

Cite this article:
B. Vamsi Krishan, CH. Babu Rao, V. Sai Kishore. Design and Development of Pulsatile drug delivery of Diltiazem Hydrochloride. Research J. Pharm. and Tech. 2020; 13(5):2315-2320. doi: 10.5958/0974-360X.2020.00417.5

REFERENCES:
1.   Suresh S, Pathak S. Chronotherapeutics: emerging role of biorhythms in optimizing drug therapy. Ind J Pharmaceutical Sci. 2005; 67: 135-40.
2.   Smolensky MH, Hermida RC, Ayala DE, Tiseo R, Portaluppi F. Administration-time-dependent effects of blood pressure-lowering medications: basis for the chronotherapy of hypertension. Blood Press Monit. 2010;15(4):173–180.
3.   Manfredini R, Boari B, Smolensky MH . Circadian variation instroke onset: identical temporal pattern in ischemic and hemorrhagic events. Chronobiol Int. 2005;22(3):417–453.
4.   Rambhau D, Sarveswar Rao V. V. Chronopharmacokinetics of Diltiazem. Drug Investigation. 1993; 6(1): 10-15.
5.   Asija Rajesh, Patel Jaimin, Asija Sangeeta, A novel approach: pulsatile drug delivery system, Int Res J of Pharmacy. 2012 ;3(9): 43-49.
6.   Kro gel, Bodmeier R. Pulsatile drug release from an insoluble capsule body controlled by an erodible plug, Pharm. Res., 1998;15 (3) : 474-481.
7.   Design and development of chrono-pharmaceutical drug delivery of lansoprazole Asian Journal of Pharmaceutical Research and Development . 2013; 1(5) :1-9.
8.   8.Dashevsky A, Kolter K, Bodmeier R. pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP. Eur J Pharm Biopharm 2004;58:45-9.
9.   Gautam Namrata, Trivedi Piyush. Formulation and development of pellets of Tolterodine tartrate: a qualitative study on Wurster based fluidized bed coating technology. Journal of Drug Delivery and Therapeutics; 2012, 2(4), 90-96.
10.   Soad A. Yehia, Ahmed H. Elshafeey, Ibrahim Sayed, Ahmed H. Shehata .Optimization of Budesonide Compression-Coated Tablets for Colonic delivery. AAPS Pharm Sci Tech. 2009; 10(1):147-157.
11.   Jeganath S, Senthilkumaran K. Formulation development and in vitro evaluation of pulsatile release tablet of budesonide. World Journal of Pharmaceutical Research .2014;4(1):1197-1208.
12.   Bhavani D, Vijaya Vani CH. S, Uma Maheshwar Rao V. Formulation and evaluation of montelukast sodium pulsatile drug delivery system by core in cup method. International Journal of Pharmacy Review and Research. 2015 ;5(1):15-23.
13.   Sai Kishore V, Narasimha Rao N, Mahalakshmi Yadav GS. Design and Development of Press Coated Prasugrel Hydrochloride Tablets for Pulsatile Drug Delivery System. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014; 5(1):1056-1064.
14.   Sai Kishore V, Sandeep M, Sudheer B. Preparation and Evaluation of Chrono-pharmaceutical Drug Delivery of Lansoprazole. Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences. 2013;2(4):45-55.
15.   Sai Kishore V, Sukanya M. Design and development of chrono-pharmaceutical drug delivery of simvastatin. Journal of Chemical and Pharmaceutical Research. 2012; 4(6):3195-3200.

Recomonded Articles:

Formulation of PLGA Polymeric Nanosuspension containing Pramipexole Dihydrochloride for improved treatment of Parkinson’s Diseases

Author(s): I. Somasundaram, B.V. Nagarjuna Yadav, S. Sathesh Kumar

DOI: 10.5958/0974-360X.2016.00155.4 Access: Open Access Read More

Taxonomical, Phytochemical and Pharmacological Reviews of Musa sapientum var. Paradisiaca.

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available Access: Open Access Read More

Qualitative Phytochemical Screening and In-vitro Anthelmintic Activity of Adhatoda vasica (Acanthaceae)

Author(s): Shabi Ruskin, R., S. Ajina

DOI: 10.5958/0974-360X.2017.00083.X Access: Open Access Read More

Study of Leachate Characterization in Landfill by Municipal Solid Waste

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6 Access: Open Access Read More

Trends in Prescribing Antihypertensive Medications and Lipid Lowering Therapy in type-2 Diabetic Patients in South Indian Tertiary Care Hospital

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1 Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0 Access: Open Access Read More