Author(s): Shikha Baghel Chauhan

Email(s): shikha.pharma@gmail.com

DOI: 10.5958/0974-360X.2020.00406.0   

Address: Shikha Baghel Chauhan
Assistant Professor, Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
Objectives: The aim of the study was to evaluate the post coital anti-implantation and antifertility studies of transdermal drug delivery of ethinylestradiol and medroxy progesterone acetate in wistar rats developed earlier in the laboratory. Medroxyprogesterone acetate (MPA), in combination with ethinylestradiol in a transdermal patch was developed and the patch was further evaluated for post coital anti implantation potential and antifertility studies. Methods: The transdermal patch was prepared by solvent casting technique using various hydrophilic and hydrophobic polymers. The formulated patch was assayed using UV spectrophotometer using Vierordt's equation for ethinylestradiol and medroxy progesterone acetate. Anti-implantation and fertility studies were performed in female wistar rats. Anti-implantation and antifertility studies were performed in female wistar rats by counting the number of implantations and antifertility studies. Results: Pharmacodynamic studies of the formulated and developed transdermal patch in female wistar rats reflected 100% anti-implantation activity. Moreover, the overall amount of drug incorporated in the transdermal patch was less as compared to oral drug delivery since the first pass metabolism was bypassed in the transdermal patch. The developed optimized patch had excellent anti implanatation potential and showed evidence of good antifertility potential. These results provided evidence that the prepared patch should be further subjected to pharmacokinetic study. Conclusion: The study concluded that there are high anti implantation and antifertility potential of the developed formulated patch containing ethinylestradiol and medroxyprogesterone acetate


Cite this article:
Shikha Baghel Chauhan. Post-coital Anti-implantation and Antifertility activity of Transdermal Drug Delivery of Ethinylestradiol and Medroxy Progesterone Acetate. Research J. Pharm. and Tech 2020; 13(5):2255-2260. doi: 10.5958/0974-360X.2020.00406.0

Cite(Electronic):
Shikha Baghel Chauhan. Post-coital Anti-implantation and Antifertility activity of Transdermal Drug Delivery of Ethinylestradiol and Medroxy Progesterone Acetate. Research J. Pharm. and Tech 2020; 13(5):2255-2260. doi: 10.5958/0974-360X.2020.00406.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-36


REFERENCES:

1.      Ghosh K, Bhattacharya TK. Preliminary study on the antiimplantation activity of compounds from the extracts of seeds of Thespesia populnea. Indian Journal of Pharmacology, 2004; 1;36(5):288.

2.      Chauhan, S. B., Naved, T., Herbal contraceptives: evaluation of antifertility potential of Hibiscus rosasinensis (linn.) Asian J. Pharm. Clin. Res., 2018; Vol 11 (11) 11, 36-41.

3.      Aitken RJ, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJ. As the world grows: contraception in the 21st century. The Journal of Clinical Investigation. 2008 Apr 1;118(4):1330-43.

4.      Chauhan A, Agarwal M, Kushwaha S, Mutreja A. Antifertility studies of Aegle marmelos Corr., an Indian medicinal plant on male albino rats. Egyptian Journal of Biology. 2008;10(1);28-35.

5.      Negi AS, Dwivedi I, Setty BS, Ray S. Benzophenones, napthophenones and related compounds as spermicidal agents. Indian Journal of Pharmaceutical Sciences,1994;56(3).

6.      Bagul MS, Kanaki NS, Rajani M. Evaluation of free radical scavenging properties of two classical polyherbal formulations Indian Journal of Experimental Biology,2005; 43 (8), 732–6.

7.      Zade V, Wikhe M, Dabhadkar D, Dawada S, Patil U. Antifertility efficacy of Cannabis sativa leaves on female albino rats. Int J Sci Invent Today. 2013;2(2):107-7.

8.      Chauhan SB. Overview and Evaluation of Antifertility Models. International Journal of ChemTech Research.. 2017;  Vol.10 (4), 151-159

9.      Chauhan SB. Perspectives of Emergency Contraceptives in India. Journal of Pharmaceutical Sciences and Research, 2016;8(9):958.

10.   Oddens BJ, Vemer HM, Visser AP, Ketting E. Contraception in Germany: a review.  Advances in Contraception, 1993 Jun 1; 9(2): 105-16.

11.   Galzote RM, Rafie S, Teal R, Mody SK. Transdermal delivery of combined hormonal contraception: a review of the current literature. International Journal of Women's Health. 2017;9:315.

12.   Kim JJ, Chapman-Davis E. Role of progesterone in endometrial cancer. Seminars in Reproductive Medicine. 2010; 28(1), 81-90.

13.   Chauhan, S., Naved, T., Formulation and development of transdermal drug delivery system of antifertility drugs using combination of polymers International Journal  of  Pharma  and Bio Sciences 2017; 8(4): 30-5.

14.   Chauhan, S., Naved, T., Formulation and Development of Transdermal Drug delivery system of Ethinylestradiol and Medroxyprogesterone acetate for Antifertility Treatment, International Journal of ChemTech Research 2017; 10 :1164-71.

15.   Beckett AH, Stenlake JB, editors. Practical pharmaceutical chemistry. New Delhi: CBC Publishers and Distributors; 1998; 284.

16.   Hubscher CH, Brooks DL, Johnson JR. A quantitative method for assessing stages of the rat estrous cycle. Biotechnic and Histochemistry.  2005;80(2):79-87.

17.   Kamath JV, Rana AC. Preliminary study on antifertility activity of Calotropis procera roots in female rats. Fitoterapia. 2002 Apr 1;73(2):111-5.

18.   Psychoyos A. Recent research on egg implantation. CIBA Foundation Study Group, London, UK, 1996.

19.   Dao B, Vanage G, Marshall A, Bardin CW, Koide SS. Anti-implantation activity of antiestrogens and mifepristone. Contraception. 1996 Oct 1;54(4):253-8.

20.   Miksicek RJ. Commonly occurring plant flavonoids have estrogenic activity. Molecular Pharmacology.1993 Jul 1;44(1):37-43.

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