Sagar D. Kadam, Shashikant Dhole, Sohan Chitlange
Sagar D. Kadam1, Shashikant Dhole2 , Sohan Chitlange1
1Derpartment of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018.
2Derpartment of Pharmaceutics, PES Modern College of Pharmacy, Moshi, Pune.
Volume - 13,
Issue - 5,
Year - 2020
For the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer Colon-specific drug delivery systems (CDDS) are used. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Colon targeted drug delivery system of Mesalamine tablets were prepared by using different formulae by direct compression method by using different concentration of Hydroxypropyl methyl cellulose (HPMC) and Ethyl Cellulose (EC). All the formulations of tablet (F1 to F6) were subjected for in vitro dissolution in 0.1 N HCL (pH 1.2) for suitability for colon specific drug delivery system. Tablets were evaluated for micrometric properties of granules, physical properties and drug content. F5 was optimized and subjected to coating based on evaluation results. The dissolution study of F5 revealed in simulated intestinal fluid release was 85.52% at the end of 6 h and was 101% at the end of 8 h. the studies confirmed that the designed formulation could be used potentially for colon delivery by controlling drug release in intestine.
Cite this article:
Sagar D. Kadam, Shashikant Dhole, Sohan Chitlange. Formulation and Evaluation of Sustained Release Colon Targeted Mesalamine Tablet. Research J. Pharm. and Tech 2020; 13(5):2241-2245. doi: 10.5958/0974-360X.2020.00403.5
1. Auer KH, Kesselhut JF. Novel pharmaceutical excipients for colon targeted drug delivery system, STP Pharm Sci. 1995; 5:54-59.
2. Marvola M, Nykanen P, Ratio S. Enteric polymers as binders and coating materials in multiple unit site specific drug delivery system, Eur Pharm Sci 7.
3. Yang, L., Chu, J.S Chu., Fix, J.A., Colon specific drug delivery: new approaches and in-vitro/in vivo evaluation. Int J Pharm, 2002; 235:1-15,.
4. Asghar L, Chandran S .Multiparticulate Formulation Approach to colon Specific Drug Delivery: Current Perspectives. 2006; 16.
5. Cole ET. Enteric coated HPMC capsules designed to achieve intestinal targeting. Int J Pharm,.2002; 231 83-95.
6. Nykanen P, Krogars K, Sakkinen M. Heinamaki J. Jurjenson H, Veski P, Marvola M. Organic acids as excipients in matrix granules for colon-specific drug delivery. Int J Pharm. 1999; 184: 251-261.
7. Ibekwe V C. A comparative in vitro assessment of the drug release performance of pH-Responsive polymers for ileo-colonic delivery. Int J Pharm. 2006;308:52-60.
8. Nykanen P, Lempaa S, Aaltonen ML, Jurjensen H, Veski P, Marvola M. Citric acidas excipient in multiple-unit enteric coated tablets for targeting drugs on the colon. Int JPharm. 2001;229: 155-162.
9. Akhgari A, Garekani HA, Sadeghi F, Azimaie M. Statistical optimization ofindomethacin pellets coated with pH dependent methacrylic polymers for possible colonic drug delivery. Int J Pharm. 2005;305: 22-30,
10. Ocana J, Frutos G, Sanchez OP, Using the similarity factor f2 in practice: A critical revision and suggestions for its standard error estimation; chemometrics and intelligen laboratory systems. 2009; 99:49-56.
11. Ritger PL, Peppas NA, A simple equation for description of solute release. II fickian and anomalous release from swellable devices. J Control Rel. 1987; 5: 37-42.
12. Costa P, Lobo JMS, Divisability of diltiazem matrix sustained relase tablets. Pharm Dev Tech. 2001; 6(3): 343-51.
13. Peppas NA, A model of dissolution controlled solute release from porous drug delivery polymeric systems. J Biomed Mater Res. 1983; 17: 1079-1087.
14. Indian Pharmacopoeia 23, New Delhi: Controller or Publication, Inc, 1996. Volume 2: 555-6.
15. Gupta AK. Introduction to Pharmaceutics, 2nd Edition. Vol 1. New Delhi, CBS Publication; 1991. 270.
16. Khandai M, Chakraborty S, Sharma A, Panda D. Development Of PropranololHydrochloride Matrix Tablets: An Investigation On Effects Of Combination Of Hydrophilic Andhydrodrophobic Matrix Formers Using Multiple Comparison Analysis. 2010; 1 (2).