Author(s): Merin. T. Koshy, Lincy Joseph

Email(s): merintk7@gmail.com

DOI: 10.5958/0974-360X.2020.00388.1   

Address: Merin. T. Koshy1*, Lincy Joseph2*
1Assistant Professor, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamil Nadu.
2Professor, Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy Thiruvalla, Kerala.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
Migraine is a common, recurrent, severe headache that interferes with normal functioning and quality of life (QOL). This prospective observational study was conducted to evaluate and compare the effectiveness and safety flunarizine(10mg), calcium channel antagonist, and propranolol(40mg) in the prophylaxis of migraine with or without aura. This Study included 70 patients of migraine and was divided into 2 treatment groups. SF 36 v1 questionaire were used for the evaluation of health related QOL. Both treatment groups led to a significant reduction in severity, frequency and duration after one month. The difference between two treatments was statistically significant. Sedation was noted with both treatments. Propranolol can be the better treatment for reducing the severity and frequency of migraine.


Cite this article:
Merin. T. Koshy, Lincy Joseph. A Prospective Study of Propranolol and Flunarizine in the Prophylactic Therapy of Migraine in a Tertiary Care Hospital. Research J. Pharm. and Tech 2020; 13(5): 2159-2162. doi: 10.5958/0974-360X.2020.00388.1

Cite(Electronic):
Merin. T. Koshy, Lincy Joseph. A Prospective Study of Propranolol and Flunarizine in the Prophylactic Therapy of Migraine in a Tertiary Care Hospital. Research J. Pharm. and Tech 2020; 13(5): 2159-2162. doi: 10.5958/0974-360X.2020.00388.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-18


REFERENCES:
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2.    Munvar Miya Shaik, Norul Badriah Hassan, Huay Lin Tan, and Siew Hua Gan. Quality of Life and Migraine Disabilty among Female Migraine Patients in a tertiary Hospital in Malaysia. Biomed Research International (2015)52.3717
3.    Sun-Young Kim and Sung-PA Park. The role of headache chronicity among predictors contributing to quality of life in patients with migraine: a hospital- based study. The Journal of Headache and Pain(2014),15:68
4.    Renan B Domingues, Andre L Pirajada Silva, Simone A. Domingues, Camila Catherine H. Aquino, Gustavo W. Kuster. A double- blind randomized controlled trail of low doses of propranolol, nortriptyline, and the combination of propranolol and nortryptiline for the preventive treatment of migraine. Arq Neuropsiquiatr (2009); 67(4):973-977.
5    Aijie He, DehuaSong, Lei Zhang and Chen Li. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. The Journal of Headache  and Pain 2017;18:26
6    Sulmaz Ghahramani, Negin Hadi, Abdolhamid Shariat, Zahra Memar, Ali Montazeri. Quality of Life of Migraine Patients Treated With Combined Propranolol and Topiramate. SMEJ. 2014; 15(4): e23277.
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DOI: 10.5958/0974-360X 

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