B. Vijayakumar, Banurekha J, G. Swarnalatha, D. Jothieswari
B. Vijayakumar1*, Banurekha J2, G. Swarnalatha3, D. Jothieswari4
1Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Koudunthirapully, Palakkad, Kerala-678004, India.
2Department of Pharmaceutical Chemistry,Vinayaka Mission’s College of Pharmacy,Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636308, Tamil Nadu, India.
3Department of Pharmaceutical Chemistry, Mahathi college of Pharmacy, C.T.M, Angalu - CTM Road, Madanapalle, Andhra Pradesh - 517325.
4Department of Pharmaceutical Ananlysis, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh-517127, India.
Volume - 13,
Issue - 5,
Year - 2020
The petroleum ether and methanol crude extracts of Rhizopora apiculata (L) (Rhizoporaceae) were screened for cytotoxicity by MTT bioassay and antioxidant activity using three different methods. The active constituents of the plant Rhizopora apiculata (L) were extracted using petroleum ether and methanol. Both extracts were tested for cytotoxicity by MTT assay at a concentration range of 18.75, 37.5, 100, 150 and 300µg/ml. The percentage cell viability shown in Pet ether extract for human cervical adenocarcinoma cell lines (HeLa), human osteosarcoma cell lines (MG 63) and Breast adenocarcinoma (MC 67) were in the range of 102-91%, 100-84% and 101-78% respectively shows that pet ether extract does not have considerable cytotoxic activity.On the other hand, Petroleum ether and methanol crude extracts of Rhizopora apiculata (L) showed mild antioxidant activity with compared to ascorbic acid.
Cite this article:
B. Vijayakumar, Banurekha J, G. Swarnalatha, D. Jothieswari. Cytotoxic and Antiradical Activities of Extracts of Rhizopora apiculata (L). Research J. Pharm. and Tech 2020; 13(5):2155-2158. doi: 10.5958/0974-360X.2020.00387.X
B. Vijayakumar, Banurekha J, G. Swarnalatha, D. Jothieswari. Cytotoxic and Antiradical Activities of Extracts of Rhizopora apiculata (L). Research J. Pharm. and Tech 2020; 13(5):2155-2158. doi: 10.5958/0974-360X.2020.00387.X Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-17
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