Author(s): Antony Justin, Chennu Manisha, Tenzin Choephel, Peet Thomas, Victoria, Jeyarani, Sayani Banerjee, Sunil Mani

Email(s): justin@jssuni.edu.in

DOI: 10.5958/0974-360X.2020.00370.4   

Address: Antony Justin, Chennu Manisha, Tenzin Choephel, Peet Thomas, Victoria, Jeyarani, Sayani Banerjee, Sunil Mani
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
Alzheimer’s disease (AD) is a chronic, slowly progressive neurodegenerative disorder and most common in elderly patients. According to World Health Organization (WHO) report 2016, about 44 million people are affected with Alzheimer’s disease (AD) worldwide. Currently, FDA approved treatment for AD is merely providing symptomatic relief rather than complete cure. The fact that AD responsible for almost 70% of dementia, it is enough to depict the depth of the situation. Hence, this brought to the new investigations respect to novel array of therapeutic options like immunotherapeutic approach for AD. Primarily it involves two approaches, namely; active immunotherapy and passive immunotherapy. Active immunotherapy approach involves the administration of antigen in order to stimulate the activation of release of antibodies. The passive immunotherapy is based on the use of antibodies directed to the C-terminus, N-terminus as well as the mid-domain of Amyloid ß peptide. Although these approaches seem to be a solution to the current therapeutic barriers, the applicability of immunotherapeutic approaches in practical scenario is far from being full filled mainly because of the numerous challenges faced. The immune reactions like meningoencephalitis, the very low penetrability of antibodies into the Blood-Brain Barrier (BBB) and lack of effective animal models pose biggest demerits. The current review investigates details of the history of clinical trials and the details of ongoing and promising trials in the field of immunotherapy for AD.


Cite this article:
Antony Justin, Chennu Manisha, Tenzin Choephel, Peet Thomas, Victoria, Jeyarani, Sayani Banerjee, Sunil Mani. Recent advances in the treatment of Alzheimer’s disease: An Immunotherapeutic approach. Research J. Pharm. and Tech 2020; 13(4):2057-2062. doi: 10.5958/0974-360X.2020.00370.4


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