Author(s): Gopinath G, Thirumal M, P. R. Kumar

Email(s): thirumal_sel@yahoo.co.in

DOI: 10.5958/0974-360X.2020.00362.5   

Address: Gopinath G, Thirumal M*, P. R. Kumar
Department of Pharmacognosy, SRM College of Pharmacy, Kattankulathur - 603203.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
Holarrhena antidysenterica belongs to the family Apocynaceae is commonly known as kurchi in Hindi, Tellicherry bark in English is a small deciduous tree which is distributed throughout the world and in India, it is found in dry forests. In Indian traditional medicine, H. antidysenterica is popularly used as a medication for dysentery, diarrhoea and intestinal worms. Plant parts such as bark are used to treat anti-microbial, anti-inflammatory, analgesics, amoebiasis, chronic bronchitis, locally for boils, ulcers; a decoction of the bark is used in bleeding and piles. The phytochemicals present in the plant include coumarins, ergosterol, flavonoids, phenolic acids, resins, saponins, steroidal alkaloids, tannins, triterpenoids. Pharmacological studies include anti-amnesic, neuroprotective, acetylcholinesterase inhibitory, anti-diabetic, anti-urolithic, antibacterial activity, anti-haemorrhoidal, analgesic activity, anti-inflammatory, anti-malarial, anti-diarrhoeal, anti-mutagenic, antihypertensive activity, antioxidant/free radical scavenging property, diuretic activity, anti-amoebic, anthelminthic, anti-microbial and anti-MRSA properties of Holarrhena antidysenterica. This review article explored the detailed investigation of the botanical description, phytochemistry and pharmacological actions of Holarrhena antidysenterica to afford an objective for further research.


Cite this article:
Gopinath G, Thirumal M, P. R. Kumar. Holarrhena antidysenterica Linn. – A Review. Research J. Pharm. and Tech. 2020; 13(4): 2011-2016. doi: 10.5958/0974-360X.2020.00362.5

Cite(Electronic):
Gopinath G, Thirumal M, P. R. Kumar. Holarrhena antidysenterica Linn. – A Review. Research J. Pharm. and Tech. 2020; 13(4): 2011-2016. doi: 10.5958/0974-360X.2020.00362.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-4-72


REFERENCES:
1.    Kavitha D, Shilpa P N, Niranjali Devaraj S. Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL. Indian Journal of Experimental Biology. 2004 Jun; 42: 589-594
2.    Gopal, Chauhen MG, Holarrena antidysenterica-A review Suppl to cultivation and utilisation of medicinal plants, Ed Handa SS, Kaul MK, Jammu Tawi, Regional research laboratory; 223-41, (1996).
3.    Mrinal, Navjeet Singh. A Review on Pharmacological Aspects of Holarrhena antidysenterica. Scholars Academic Journal of Pharmacy. 2018 Dec; 7(12): 488-492
4.    Warrier PK, Nambiar VP, Ramankutty C. Indian medicinal plant: A compendium of 500 species, Orient Longman, Delhi, 1994, 191-194.
5.    Sharma PC, Pyelne MB, Dennis TJ. Database on medicinal plants used in ayurveda, Vol 2, Central council for research in ayurveda and siddha, New Delhi, 2004,550.
6.    Umashanker KPD, Chandra S, Sharma J. Antidiabetic Efficacy of Ethanolic Extract of Holarrhena antidysenterica Seeds in Streptozotocin – Induced Diabetic Rats and Its influence on certain Biochemical Parameters. Journal of Drug Delivery and Therapeutics. 2012 Jun; 2(4): 159-162.
7.    Darji VC, Deshpande S, Bariya AH. Comparison between the effect of aqueous and methanolic extracts of Holarrhena antidysenterica bark against experimentally induced inflammatory bowel disease. International Research Journal of Pharmacy. 2013; 4 (1): 131-134.
8.    Mahato S, Mehta A and Roy S. Studies on antibacterial effects of bark, seed and callus extracts of Holarrhena antidysenterica wall. The Bioscan. 2013; 8(2): 717-721.
9.    Khan A, Khan S R, Gilani A.H, Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica. Urol. Res. 2012 Dec; 40(6): 671-681.
10.    Rajalakshmi C. GC-MS analysis of the bark of Holarrhena antidysenterica. Journal of Pharmacognosy and Phytochemistry. 2018; 7(4): 797-800
11.    Prajapati ND, Purohit SS, Sharma AK, et al. A Handbook of Medicinal Plants. Jodhpur, India: Agrobios Publishers; 2004. p 273.
12.    Bhattacharjee SK, Handbook of Medicinal Plants Jaipur, India: Pointer Publishers 2000; p 183.
13.    Guha Bakshi DN, P Sensarma and DC Pal A, Lexicon of Medicinal Plants in India (2001) (Vol II), Calcutta, India: Naya Prokash Publishers; p 356-358.
14.    Jamadagni PS, Pawar SD, Jamadagni SB, Chougule S, Gaidhani SN and Murthy SN. Review of Holarrhena Antidysenterica (L.) Wall. Ex A. DC. Pharmacognostic, Pharmacological, and Toxicological Perspective. Pharmacognosy Review. 2017; 11(22): 141–144.
15.    Ganapathy PS, Ramachandra YL, Rai SP. In vitro antioxidant activity of Holarrhena antidysenterica Wall. Methanolic leaf extract. Journal of Basic and Clinical Pharmacy. 2011 Nov; 2(4): 175-178.
16.    Sharma DK, Gupta VK, Kumar S, Joshi V, Mandal RSK, Prakash AGB, Singh M. Evaluation of antidiarrhoeal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Veterinary World. 2015 Dec; 8(12): 1392-1395.
17.    Dictionary of Indian Medicinal Plants, CIMAP, Lucknow (1992).
18.    Ali Shah SM, Khan Usmanghani, Naveed Akhtar, Asif HM, Akram M, Khalil Ahmed, Ghazala Shaheen, Tahira shamim, Riazur Rehman, Ashfaq Ahmad, Laila Sumreen. Monograph of Holarrhena antidysenterica (Linn.) Wall. International Journal of Phytomedicine 2 (2010); 345-348
19.    Mohammed Rahmatullah, Baharul Islam, Arif Khan Md, Shoma JF, Taufiq Rahman. “Holarrhena antidysenterica (Linn.) Wall. (Apocynaceae) – A Plant for Gastrointestinal Disorders”. EC Gastroenterology and Digestive System 5.6 (2018): 437-443.
20.    Nadkarni KM. Indian plants and drugs. New Delhi. Ajay Book Service Publishers. 2010.
21.    Dev S. A Selection of Prime Ayurvedic Plant Drugs: Ancient-modern Concordance. New Delhi: Anamaya; 2006.
22.    Alauddin M, Martin-Smith M. Biological activity in steroids possessing nitrogen atoms. Journal of Pharmacy and Pharmacology. 1962; 14: 469-495.
23.    Daniel M. Medicinal Plants: Chemistry and Properties. Enfield, NH: Science; 2006.
24.    Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena  antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin. 2007 Jun; 55(6): 912-914.
25.    Yang ZD, Duan DZ, Xue WW, Yao XJ, Li S. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships. Life Sciences. 2012; 90: 929-933.
26.    Stephenson RP. The pharmacological properties of conessine, isoconessine and neoconessine. British Journal Pharmacology. 1948; 3: 237-245.
27.    Usmani SB. Studies on the Chemical Constituents of Holarrhena antidysenterica L. and the b-carboline Series of Bases and Their Pharmacological Activity. Thesis. Pakistan: H.E.J. Research Institute of Chemistry, University of Karachi; 1995.
28.    Chakraborty A, Brantner AH. Antibacterial steroid alkaloids from the stem bark of Holarrhena pubescens. Journal of Ethanopharmacology. 2000 Jan; 68(1-3): 339-344.
29.    Siddiqui BS, Usmani SB, Ali ST, Begum S, Rizwani GH. Further constituents from the bark of Holarrhena pubescens. Phytochemistry. 2001; 58: 1199-1204.
30.    Lather A, Gupta V, Bansal P, Singh R, Chaudhary AK. Pharmacological potential of ayurvedic formulation: Kutajghan-Vatie A review. Journal of Advanced Scientific Research. 2010; 1(2): 41-45.
31.    Panda SK, Patra N, Sahoo G, Bastia AK, Dutta SK. Antidiarrhoeal activities of medicinal plants of Similipal Biosphere Reserve, Odisha, India. International Journal of Medicinal and Aromatic Plants. 2012; 2(1): 123-134.
32.    Kumar A, Ali M. A new steroidal alkaloid from the seeds of Holarrhena antidysenterica. Fitoterapia. 2000; 71: 101-104.
33.    Verma G, Dua VK, Agarwal DD, Atul PK. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya. Malaria Journal. 2011;10(20): 1-5
34.    Mrinal, Navjeet Singh, Nitin Bansal. Anti-amnesic Activity of Holarrhena Antidysenterica Extract in Streptozotocin-Induced Memory Deficient Rats. Scholars Academic Journal Pharmacy. 2016; 5(8): 317-325.
35.    Bansal N, Singh N, Mrinal. Holarrhena Antidysenterica Extract Promotes Recovery of Peripheral Neuropathy in Diabetic Rats. American Journal of Pharma Tech Research. 2016; 6(4): 2249-3387.
36.    Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology. 1961; 7(2): 88-95.
37.    Orhan I, Sener B, Choudhary MI, Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. Journal of Ethnopharmacology. 2004; 91(1): 57-60.
38.    Kazi MA, Tushar KB, Suvra M, Bikash RB, Debidas G. Attenuation of diabetic disorders in experimentally induced diabetic rat by methanol extract of seed of Holarrhena antidysenterica. International Journal of Pharma Tech Research. 2010; 1: 1205-1211.
39.    Pradeep Sahu, Anindh Sharma, Tanushree Chatterjee. Natural Products with Potent Hypoglycemic Activity. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 650-656
40.    Mana S, Singhal S, Sharma NK, Singh D. Hypoglycemic Effect of Holarrhena antidysenterica Seeds on Streptozotocin induced Diabetic Rats. International Journal of Pharma Tech Research. 2010; 2(2): 1325-1329.
41.    Berg JM, Tymoczko JL, Stryer L. Glycolysis and gluconeogenesis. In: Biochemistry. Berg JM, Tymoczko JL, Stryer L. (Eds). W.H. Freeman: New York. 2001; 425-464.
42.    Das D. 2002. Biochemistry, 11th edition, Kolkata, Academic Publishers, p-448.
43.    Ali KM, Chatterjee K, De D, Bera TK, Ghosh D. Efficacy of aqueous extract of seed of Holarrhena antidysenterica for the management of diabetes in experimental model rat: A correlative study with antihyperlipidemic activity. International Journal of Applied Research in Natural Products. 2009; 2(3): 13-21.
44.    Ali KM, Chatterjeea K, Dea D, Janaa K, Beraa TK, Ghosha D. Inhibitory effect of hydro-methanolic extract of seed of Holarrhena antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rats. Journal of Ethnopharmacology. 2011; 135: 194–196.
45.    Monago Comfort C., Nwodo O. Fred C. Antidiabetic Effects of Crude Flavanoid and Alkaloid of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbits. Research J. Pharmacognosy and Phytochemistry 2010; 2(4): 331-335.
46.    Kavitha D, Niranjali S. Inhibition of enteropathogenic Escherichia coli adhesion on host epithelial cells by Holarrhena antidysenterica (L.) WALL. Phytotherapy Research, 2009; 23: 1229–1236.
47.    Premlata Singariya, Krishan Kumar Mourya, Padma Kumar. Estimation of Antibacterial Efficacy in Alkaloids of Anogeissus rotundifolia an Indigenous Medicinal Plant against Some Pathogenic Micro-organisms. Asian J. Research Chem. 2018; 11(2):432-440.
48.    Pal A, Sharma PP, Mukherjee PK. A clinical study of Kutaja (Holarrhena antidysenterica Wall) on Shonitarsha. An International Quarterly Journal of Research in Ayurveda. 2009; 30(4): 369-372.
49.    Pankaj Rakha, Manju Nagpal, Sunil Sharma, Milind Parle. Anti-Inflammatory Activity of Petroleum Ether Extract of Seeds of Ocimum Basilicum Linn. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 589-591.
50.    Shwetha C, Latha KP, Asha K. Study on analgesic activity of Holarrhena antidysenterica leaves. International Journal of Herbal Medicine. 2014; 2(3): 14-16.
51.    Manpreet Kaur, Harinder Kaur. Analgesic Activity of Roots of Aralia racemosa. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1896-1897.
52.    Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal DD, Gupta NC, Kumar S, Rastogi A. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malaria journal. 2013 Dec; 12(1): 194.
53.    Takate S.B, Pokharkar R.D, Chopade V.V. Gite V.N. Hepatoprotective Activity of the Water Extract of Launaeaintybacea (Jacq)Beauv in Paracetamol Induced Hepato-Toxicity in Albino Rats. Research J. Pharm. and Tech.2010; 3(3):p.815-817
54.    Dey A, De JN. Ethnobotanical Survey of Purulia district, West Bengal, India for medicinal plants used against gastrointestinal disorders. Journal of Ethnopharmacology. 2012; 143: 68-80.
55.    Gupta K, Karale S, Warad V. Anti-diarrhoeal activity of a polyherbal formulation in various animal models of diarrhoea. International Research Journal of Pharmacy. 2012; 3(8): 289-290.
56.    Lin J, Opoku AR, Geheeb-Keller M, Hutchings AD, Terblanche SE, Jager AK, Van Staden J. Preliminary screening of some traditional Zulu medicinal plants for anti-inflammatory and antimicrobial activities. Journal of Ethnopharmacology. 1999; 68: 267-274.
57.    Somanadhan B, Varughese G, Palpu P, Sreedharan R, Gudiksen L, Smitt UW, Nyman U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. Journal of ethnopharmacology. 1999 May 1; 65(2):103-112.
58.    Aqil F, Zahin M, Ahmad I. Antimutagenic activity of methanolic extracts of four ayurvedic medicinal plants. Indian Journal of Experimental Biology. 2008; 46(9): 668-672.
59.    Ali KM, Ghosh A, Chatterjee K, Mandal S, Barik B, Pathak TK, Ghosh D. Free radical scavenging activity of seed of Holarrhena antidysenterica: an in vitro study. Journal of Pharmacy Research. 2011; 4(6): 1631-1632.
60.    Khan A, Bashir S, Gilani AH. An in vivo study on the diuretic activity of Holarrhena antidysenterica. African Journal of Pharmacy and Pharmacology. 2012 Feb 22; 6(7): 454-458.
61.    N Sirisha, M Sreenivasulu, K Sangeeta, G Swarna Latha, A Lakshmi Devi, C Madhusudhana Chetty. A Review on Herbal Diuretics. Research J. Pharm. and Tech. 4(3): March 2011; Page 335-348.
62.    Shahabuddin KU, Sarwar MS, Mohiuddin E. Clinical evaluation of some herbal medicine for amoebiasis. Pakistan Journal of Pharmacology. 2006 Jul; 23(2): 9-12.
63.    Sunirmal Bhattacharjee, Nilayan Guha, Gouranga Dutta, Manas Chakraborty, Mayukh Jana, Susanta Paul. Formulation and Evaluation of Sustained Release Matrix Tablet of Anti-Amoebic Drug by Natural Polymers. Research J. Pharm. and Tech. 2017; 10(7): 2041-2046.
64.    Patil R, Devkar S, Pawar P, Pattewar A. In-vitro anthelminthic activity of Holarrhena antidysenterica bark. International Journal of Pharmaceutical Research and Development. 2012; 4(3): 147-150.
65.    Patel JD, Patel DK, Shrivastava A, Kumar V. Screening of plant extracts used in traditional antidiarrhoeal medicines against pathogenic Escherichia coli. Scientific World journal. 2008; 6(6): 63-67.
66.    Farrukh A, Iqbal A, Mohd O. Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts. Biotechnology Journal 2006; 1:1093–1102
67.    Pritt Verma, Sajal Srivastava, Ch. V. Rao. Hepatoprotective effect of Ethanolic Extract of Holarrhena antidysenterica against Paracetamol Induced Toxicity in Wistar Rats. Research J. Pharm. and Tech 2018; 11(4): 1633-1639
68.    Jiban Debnath, Santosh B Dighe, Nachiket S Dighe, Mana Supriya. An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica In Mice. Research J. Pharmacology and Pharmacodynamics. 2011; 3(1): 31-33.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available