Nanoemulsions are transparent system mostly covering droplet size in nanometric scale because of their small droplet sizes. This review aims on the method of formulation, evaluation Methods, advantages and disadvantages and the different route of drug delivery of Nanoemulsion. Nanoemulsion is utilized as transdermal drug delivery and characterized as required component, which optimal isotropic and thermodynamically settled aqueous solute with droplet size generally in the size range from 10 to 200 nm. To improves the soluble and permeability of slightly water dissoluble drug. The in-vitro skin penetration profile of optimized manufacturing were compared with general drug formulation. The factors determines the transdermal penetration of medications are the movement of medication in solvent, discharge the medication solvent, also penetration of drug within skin These are enhancing the rate of absorption discharge volatility in absorption and enhance bioavailability. The methods used for the preparation of Nanoemulsions include high pressure homogenization, Microfluidization, ultrasonication, and spontaneous emulsification. The prepared Nanoemulsions are Characertized by in vitro drug release, Thermodynamical stability studies, Nanoemulsion Droplet size.The future direction on Nanoemulsion is to study the drug delivery of topical, parenteral, intravenous and other route of administration. In this review, the discussion is intended to give a basic knowledge about its preparation, evaluation, mechanism and its application.
Cite this article:
Vishali Mathialagan, Abimanyu Sugumaran, Damodharan Narayanaswamy. Nanoemulsion: Importance in Pharmaceutical Nanotechnology. Research J. Pharm. and Tech. 2020; 13(4):2005-2010. doi: 10.5958/0974-360X.2020.00361.3
1. Gurpreet K and Singh SK. Review of Nanoemulsion Formulation and Characterization Techniques. Indian J Pharm Sci, 2018;80(5): 781-789.
2. Radhika PR, Guruprasad S. Nanoemulsion Based Emulgel Formulation of Lipophilic Drug for Topical Delivery. Int J PharmTech Res, 2016;9(6):210-23.
3. Shafiq S, Shakeel F, Talegaonkar S Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharma Biopharm,2007; 66: 227–243.
4. Mei Z, Chen H, Weng T .Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharma Biopharm, 2003; 56: 189–196.
5. Azeem A, Rizwan M, Ahmad FJ Nanoemulsion components screening and selection: A technical note. AAPS Pharmscitech,2009; 10: 69–76.
6. Wang L, Li X, Zhang G .Oil-in-water nanoemulsions for pesticide formulations. J Colloid Interf Sci, 2007; 314: 230–235.
7. Rajpoot P, Pathak K, Bali V .Therapeutic applications of nanoemulsion based drug delivery systems: A review of patents in last two decades. Rec Patents Drug Del Formul,2011; 5: 163–172.
8. Prow TW, Grice JE, Lin LL, Faye R, Butler M, Becker W, Wurm EM, Yoong C, Robertson TA, Soyer HP, Roberts MS. Nanoparticles and microparticles for skin drug delivery. Adv Drug Deliv Rev,2011; 63(6):470–491.
9. Souto EB, Muller RH Cosmetic features and applications of lipid nanoparticles (SLN, NLC). Int J Cosmet Sci, 2008; 30(3):157–165
10. Roy SD, Gutierrez M, Flynn GL, Cleary GW .Controlled transdermal delivery of fentanyl: characterizations of pressure-sensitive adhesives for matrix patch design. J Pharm Sci , 1996; 85(5):491–495.
11. Devarajan V and Ravichandran V. Nanoemulsions, As modified drug delivery tool Pharmacie Globale. Int J Comp Pharma. 02(04);2004: 01-06..
12. Anton N and Vandamme TF. Nano-emulsions and micro-emulsions: clariﬁcations of the critical differences. Pharm Res, 2010; 28(5):978–985.
13. Porras M, Martínez A, Solans C, González C,Gutierrez JM. Ceramic particles obtained using W/Onano-emulsions as reaction media Colloids and Surfaces A, Physicochemical and Engineering Aspects, 2005; 270–271: 189–94.
14. Setya S, Talegaonkar S, Razdan BK. Nanoemulsions: formulation methods and stability aspects. World J. Pharm. Pharm. Sci, 2014; 3(2): 2214-2228.
15. Alvarez- Figueora M J , Blanco Mendez J. Transdermal delivery of methotrexate Iontophoretic delivery from hydrogels and passive delivery from microemulsion. Int J pharm, 2001;215: 57-65.
16. Bhatt P and Madhav S. A Detailed Review on Nanoemulsion Drug Delivery System. International Journal of Pharmaceutical Sciences and Research, 2011; 2(10):2482-2489.
17. KhHussan R. Nanoemulsion as a Novel Transdermal Drug Delivery System. International Journal of Pharmaceutical Sciences and Research, 2011; 2(8):1938-1946.
18. Patil H, Waghmare J. Nanoemulsion: Current state and perspectives. Res. J. Topical and Cosmetic Sci.2013; 4(1): 32-40.
19. Panchagnula R, Bokalial R, Sharma P, Khandavilli S. Transdermal delivery of naloxone: skin permeation, pharmacokinetic, irritancy and stability studies. Int J Pharm, 2005;293:213–223.
20. Singh Y, Gopal Meher J , Raval K , Ali Khan F , Chaurasia M , Nitin K, Chourasia M. Nanoemulsion: Concepts, development and applications in drug delivery. Journal of Controlled Release, 2017; 252: 28–49.
21. Sunil Kumar. role of nano-emulsion in pharmaceutical sciences-a review. Asian Journal of Research in Pharmaceutical Sciences and Biotechnology, 2014; 2(1): 1 - 15.
22. Thakur N, Garg G, Sharma PK, Kumar N. Nanoemulsions: a review on various pharmaceutical application. Global J. Pharmacol, 2012; 6(3): 222-225.
23. Kumari Ch TL, Sowjanya GN, Bandhavi P. Nanoemulsions an emerging trend: a review. IJPRD, 2012; 4(6): 137-152.
24. Uluata S, Decker EA, McClements DJ. Optimization of nanoemulsion fabrication using microfluidization: role of surfactant concentration on formation and stability. Food Biophys ,2016;11:52-9.
25. Anton N and Vandamme T F. Nano‐emulsions and micro‐emulsions: Clarifications of the critical differences. Pharmaceutical Research, 2011; 28(5): 978–985.
26. Ahuja A Ali J, Baboota S, Faisal MS, Shakeell F and Shafiq S. Stability evaluation of Celecoxib nanoemulsion containing Tween 80. Thai J. Pharm. Sci, 2008;32 : 4-9.
27. Haritha, Peer Basha S, Koteswara Rao P, i Vedantham C. A brief introduction to method of preparation, application and characterization of Nanoemulsion drug delivery systems. Indian Journal of Research in Pharmacy and Biotechnology,2016; Vol.1:21-25
28. Sukanya G and Anjum S. Review on Nanoemulsions. International Journal of Innovative Pharmaceutical Sciences and Research, 2013;Vol.1 (2):192-205.
29. Bankaer G and Libberman H. Pharmaceutical Dosage Forms, Dispense Systems, Marcel Dekker. journal of pharm sci, 2002: 339-344.
30. Devrajan V Nanoemulsion: As Modified Drug Delivery Tool. International Journal of Comprehensive Pharmacy, 2011; 4 (01): 1-6.
31. Dhiman D, kumar Pal A, Mittal A, Saini S. Preparation and evaluation of nano-emulsion formulation by using spontaneous emulsification. PharmaTutor, 2017; 5(1): 54-58.
32. Debnath S, Vijay Kumar G , Satayanarayana SV. Design, Development and Evaluation of Novel Nanoemulsion of Terbinafine HCl. Research J. Pharm. and Tech, 2012; 5(10): 1301-1307.
33. Bouchemal K, Briancon S, Fessi H, Perrier E. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization. Int J Pharm, 2004;280:242.
34. Suyal J, Bhatt G and Singh N. Formulation and evaluation of nanoemulsion for enhanced bioavailability of Itraconazole. Int J Pharm Sci Res, 2018; 9(7): 2927-31.
35. Tamilvanan S, Schmitd S, Muller RH, Benita S. In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration. Eur. J. Pharm. Biopharm, 2005; 20:1 –7.
36. Saudagar RB, Vaishnav S. Pharmaceutical Nano emulsion as a Rational Carrier for Drug Delivery. Research J. Pharm. and Tech, 2016; 9(3) : 298-304.
37. Aggarwal P, Hall JB, McLeland CB , Dobrovolskaia MA, McNeil SE. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv. Drug Deliv. Rev, 2009; 61: 428–437.
38. Szebeni J, Alving CR, Rosivall L, Bunger R, Baranyi L, Bedocs P, Toth M, Barenholz Y. Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles. J. Liposome Res, 2007; 17: 107–117.
39. Mou D, Chen H, Du D, Mao C, Wan J, Xu H, Yang X. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int. J. Pharm, 2008; 353: 270–276.
40. Khandavill S, Panchagnula R. Nanoemulsions as versatile formulations for paclitaxel delivery: peroral and dermal delivery studies in rats. J. Investig. Dermatol, 2007;127: 154–162.
41. Fang J Y, Yu S Y, Wu P C, Huang Y B, Tsai Y H. In-vitro skin permeation of estradiol from various proniosome formulations. Int. J. Pharm, 2001; 215:91–99.
42. Song Z, Sun H, Yang Y, Jing H, Yang L, Tong Y, Wei C, Wang Z, Zou Q and Zeng H. Enhanced efficacy and antibiofilm activity of novel nanoemulsions against skin burn wound multi-drug resistant MRSA infections. Nanomedicine 2016; 12: 1543–1555.
43. Nastiti C, Ponto T, Abd E, Grice J, Benson H, and Roberts M. Topical Nano and Microemulsions for Skin Delivery. Pharmaceutics, 2017; 9(4): 37.
44. Sánchez-López E, Guerra M , Dias-Ferreira J , Lopez-Machado A, Ettcheto M, Cano A, Espina M, Camins A, Luisa Garcia M and Souto E. Current Applications of Nanoemulsions in Cancer Therapeutics. Nanomaterials,2019; 9: 821.
45. Patel PA, Chaulang GM , Akolkotkar A, Mutha SS, Hardikar SR and Bhosale AV. Self Emulsifying Drug Delivery System: A Review. Research J. Pharm. and Tech, 2008;1(4): 313-323
46. Uma Sankari K, Alagusundaram M, Krishna Sahithi G, Madhu Sudhana Chetty C, Ramkanth S, Angalaparameswari S and Mohammed Saleem TS. Nanoemulsions - Approaching Thermodynamic Stability.2010; 3(2): 319-326.
47. Patel J, Shah A. Self emulsifying delivery systems for poorly absorbed drugs. Int. J. Pharm. Sci. and Nano Tech. 2008; 1(2) : 123-128.
48. Patel PA, Chaulang GM. Self emulsifying drug delivery system. Research J. Pharm. and Tech. 2008; 1(4): 313-323.
49. Rutvij JP, Gunjan JP, Bharadia PD, Pandya VM, Modi DA. Nanoemulsion an advanced concept of dosage form. Int. J. Pharm. Cosmetol 2011; 1: 122-133.
50. Kalimuthu S and Yadav AV. Nanobased Drug Delivery System: A Review. Research J. Pharm. and Tech, 2009; 2(1): 21-27