Author(s): Wisam H. Hoidy, Shaimaa M. Essa, Fouad A. Al-Saady, Emad A. Jaffar Al-Mulla

Email(s): wisam.hoidy@qu.edu.iq

DOI: 10.5958/0974-360X.2020.00348.0   

Address: Wisam H. Hoidy1*, Shaimaa M. Essa1, Fouad A. Al-Saady2, Emad A. Jaffar Al-Mulla3
1Chemistry Department, College of Education, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
2College of Pharmacy, Al-Mustansiriyh University, Baghdad, Iraq.
3College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
Carbamodithioic acid is a compound derived from thiourea. Thioureas have a significant role in medical chemistry and agriculture because of their biological action as herbicides and rodenticides, also antiviral antibacterial, and antifungal, in addition, anti-HIV and anti-tumor agents and phenoloxidase enzymatic inhibitors. The paper sheds light on Difatty acyl carbamodithioic acid (DFACA) that has antibiotics and antifungal actions that have been made out of corn oil and carbamodithioic acid employing sodium ethoxide as a catalyst. glycerol and Ethyl fatty ester (EFE) are manufactured as secondary products. The synthesis is achieved through refluxing corn oil with carbamodithioic acid in ethanol. In this method, corn oil transformed into about 83% pure DFACA after 10 hrs and a molar ratio of carbamodithioic acid compared to corn oil was 6.0: 1 at 80C. Analysis of elements, 1H nuclear magnetic resonance (NMR) technique and Fourier transform infrared (FTIR) spectroscopy are employed to portray DFACA and EFE. The new compounds (DFACA) was filtered for antimicrobial actions using disc diffusion method for antimicrobial activity against two samples of Gram-positive bacteria and two samples of Gram-negative bacteria represented by "Staphylococcus Aureus and Bacillus Subtilis" and "Escherichia Coli and Klebsiella pneumonia", respectively. Also, examine the effect of DFACA on fungus Candida albicans. The result disclosed that the (DFACA) has high biological activity. The result disclosed that the (DFACA) has high biological action.


Cite this article:
Wisam H. Hoidy, Shaimaa M. Essa, Fouad A. Al-Saady, Emad A. Jaffar Al-Mulla. Synthesis, Characterization and Evaluation of Biological Activity of Corn Oil -Based Difatty Acyl Carbamodithioic Acid. Research J. Pharm. and Tech. 2020; 13(4):1931-1935. doi: 10.5958/0974-360X.2020.00348.0


REFERENCES:
1.    Phuong T, Khac-Minh T, Van Hal NT, Phuong HT. Synthesis and antifungal activities of phenylenedithioureas. ACS Medicinal Chemistry Letters. 2004; 14: 653-656.
2.    Amadus K, Suresh G, Janarthanan N, Masilamani S. Antifungal activity of 1,3-disubstituted symmetrical and unsymmetrical thioureas. Pesticide Science. 1998; 52: 145-151.
3.    Hoidy WH, Ahmad MB, Al Mulla EA, Ibrahim NA. Modification of montmorillonite by Difattyacyl thiourea using cation exchange process. Oriental Journal of Chemistry. 2010; 26: 409-414.
4.    Kuo TM, Kim H, Hou CT. Production of novel compound 7,10,12-trihydroxy-8(E)-octadecenoic acid from ricinoleic acid by Pseudomonas aeruginosa PR3. Current Microbiology. 2001; 43: 198-203.
5.    Richard AR. Industrial uses of palm, palm kernel and coconut oils: Nitrogen derivatives. Journal of the American Oil Chemists' Society. 1985; 62: 255–265.
6.    Neeraj PA, Singh RP. Microwave–assisted facile and convenient synthesis of fatty acid amide (Erucamide): Chemical–catalyzed rapid method. European Journal of Lipid Science and Technology. 2009; 111: 202–206.
7.    De Zoete MC, Kock–van AC, van Rantwijk F, Sheldon RA. Lipase catalyzed ammoniolysis of lipids: a facile synthesis of fatty acid amides. Journal of Molecular Catalysis B: Enzymatic. 1996; 1: 109-113.
8.    Litjens MJ, Sha M, Straathof AJ, Jongejan JA, Heijnen JJ. Competitive lipase catalyzed ester hydrolysis and ammoniolysis in organic solvents: Equilibrium model of solid liquid vapor system. Biotechnology and Bioengineering. 1999; 65: 347-356.
9.    Levinson WE, Kuo TM, Kurtzman CP. Lipase catalyzed production of novel hydroxylated fatty amides in organic solvents. Enzyme and Microbial Technology. 2005; 37: 126-130.
10.    Neu HC. The Crisis in Antibiotic Resistance. Science. 1992; 257: 1064-1073
11.    Michel M, Gutmann L. Methicillin-resistant Staphyllococus aureus and vancomycin resistant enterococci: Therapeut Realities and Possibilities. Lancet. 1997; 349: 1901-1906.
12.    James SF, Gene MO. Extraction of metal ion with N, N– disubstituted amides. Analytical Chemistry. 1975; 47: 2043-2045.
13.    Adams C, Peter JF, Rand MC, Schroer BJ, Ziemke KC. Investigation of soybean oil as a diesel fuel extender: endurance tests. Journal of the American Oil Chemists' Society. 1983; 60: 1574-1579.
14.    Holser RA, Harry–O’Kuru R. Transesterified milkweed (Asclepias) seed oil as a biodiesel fuel. Fuel. 2006; 85: 2106-2110.
15.    Basiron Y, Ashiq U, Ara R, Tahir MM, Maqsood ZT, Khan KM, Khan SN, Siddiqui H. Palm oil production through sustainable plantations. European Journal of Lipid Science and Technology. 2007; 109: 289-299.
16.    Hoidy WH, Ahmad MB, Al-Mulla EA, Yunus ZM, Ibrahim NA. Synthesis and Characterization of Fatty Hydroxamic Acids from Triacylglycerides. Journal of Oleo Science. 2010; 59: 15-19.
17.    Hoidy WH, Ahmad MB, Al-Mulla EA, Yunus WM, Ibrahim NA. Chemical Synthesis and characterization of N - hydroxy - N - methyl Fattyamide from Palm Oil. Oriental Journal of Chemistry. 2010; 26: 369-372.
18.    Essa Sh. Spectrophotometric determination for chromium (III) and cobalt (II) with 4-(nitro phenyl azo imidazole) (NPAI) as organic reagent. Journal of Chemical and Pharmaceutical Research. 2016; 8: 85-92.
19.    Al-Mulla EA, Yunus ZM, Ibrahim NA, Rahman MZ. Synthesis, characterization and optimum reaction conditions of fatty hydrazide from triacylglycerides. Research Journal of Applied Sciences. 2008; 3: 545-549.
20.    Al-Mulla EA, Yunus WM, Nor AI, Rahman MZ. Synthesis and characterization of N, N’-carbonyl difatty amides from palm oil. Journal of Oleo Science. 2009; 58: 467-471.

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