Author(s): Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna, Rangisetty Spandana Yasaswini

Email(s): mannapurna.mukthinuthalapati@gitam.edu

DOI: 10.5958/0974-360X.2020.00341.8   

Address: Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna*, Rangisetty Spandana Yasaswini
GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
New spectrophotometric methods have been established for the determination of Tavaborole in pharmaceutical formulations. Tavaborole is an antifungal agent used for the fungal infection of nail (onychomycosis). Tavaborole is chemically known as 5 - Fluoro -1,3 - dihydro -2,1-benzoxaborol -1-ol. Tavaborole has shown absorption maxima at 271 nm in all the methods. A calibration curve was drawn by taking the concentration on the X – axis and their respective absorbance on Y – axis for all the methods. Tavaborole obeys Beer-Lambert’s law over the concentration range 1-100µg/ml for all the above mentioned methods. The linear regression equations were found to be y = 0.0049x + 0.0017(R² = 0.9999) and all the methods are validated as per ICH guidelines.


Cite this article:
Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna, Rangisetty Spandana Yasaswini. New validated analytical methods for the determination of Tavaborole (An anti-fungal agent). Research J. Pharm. and Tech. 2020; 13(4):1893-1898. doi: 10.5958/0974-360X.2020.00341.8


REFERENCES:
1.    Toledo-Bahena ME, Bucko A, Ocampo-Candiani J, Herz-Ruelas ME, Jones TM, Jarratt MT, Pollak RA, Zane LT: The efficacy and safety of Tavaborole, a novel, boron-based pharmaceutical agent: Phase 2 studies conducted for the topical treatment of toenail onychomycosis. J Drugs Dermatol. 2014; 13(9): 1124-1132.
2.    Boni EE, Raza Aly, Sheryl LB et al., Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies". Journal of the American Academy of Dermatology. 2015; 73 (1): 62–69.
3.    Markham A: Tavaborole: first global approval. Drugs 2014 Sep; 74(13): 1555-58.
4.    Siva Rao T, Venu Balireddi and Krishna Murthy T. Analytical method development and validation of stability indicating method of RP-HPLC for quantification of Tavaborole related substances: Application to 5% topical solution. European Journal of Biomedical and Pharmaceutical Sciences, 2018; 5(9): 545-550.
5.    Tampucci Silvia, Terreni Eleonora, Burgalassi Susi, Chetoni Patrizia, Monti Daniela. Development and Validation of an HPLC-UV Method to Quantify Tavaborole During in Vitro Transungual Permeation Studies. Journal of AOAC International, 2018; 101(2): 437-443.
6.    ICH Q2 [R1] validation of analytical procedures: Text and Methodology: November 2005.

Recomonded Articles:

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima

DOI: 10.5958/0974-360X.2016.00101.3         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags