Author(s):
Radhika Parasuram Rajam, Aswini Balaji, Karthi Raja A Shanmugam, Vishnu Kumar Palanichamy
Email(s):
radhi_kannan2005@yahoo.co.in
DOI:
10.5958/0974-360X.2020.00324.8
Address:
Radhika Parasuram Rajam*, Aswini Balaji, Karthi Raja A Shanmugam, Vishnu Kumar Palanichamy
Department of Pharmaceutics, The Erode College of Pharmacy and Research Institute, Erode, Tamilnadu, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 4,
Year - 2020
ABSTRACT:
The objective of the present study was formulation and evaluation of sustained release dosage form of Vildagliptin sodium alginate beads. Vildagliptin is an anti-diabetic drug of the new di-peptidyl peptidase-4 inhibitor class of drug. Vildagliptin is one of the emerging short acting drugs, so the developed formulations provide the advantage of sustained release formulations. Vildagliptin gel beads were prepared by Emulsion gelation method, using sodium alginate and castor oil. Three different formulations (F1, F2, and F3) were prepared by using the drug: polymer ratio as 1:1, 1:2, and 1:3respectively. The gel beads containing oil were prepared by gentle mixing or homogenizing oil and water phase containing sodium alginate and the mixture were then extruded into calcium chloride solution to 6produce the gel beads. F2 was the optimized formulation and further studies were done. The surface morphology and the other characteristic studies such as size analysis and distribution, swelling index, Buoyancy studies and the In-vitro studies were studied. The oil entrapped calcium alginate gel beads showed sustained release. Scanning electron photomicrographs showed the minute oil globules on the surface of the beads.
Cite this article:
Radhika Parasuram Rajam, Aswini Balaji, Karthi Raja A Shanmugam, Vishnu Kumar Palanichamy. Formulation and Evaluation of Vildagliptin Beads by Emulsion Gelation Method. Research J. Pharm. and Tech. 2020; 13(4):1799-1803. doi: 10.5958/0974-360X.2020.00324.8
Cite(Electronic):
Radhika Parasuram Rajam, Aswini Balaji, Karthi Raja A Shanmugam, Vishnu Kumar Palanichamy. Formulation and Evaluation of Vildagliptin Beads by Emulsion Gelation Method. Research J. Pharm. and Tech. 2020; 13(4):1799-1803. doi: 10.5958/0974-360X.2020.00324.8 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-4-34
REFERENCE:
1. Elas J.I and Longo N, Glucose transporters, Annu Rev, Med, 1992,:43: 377-393
2. USP Convention Kroweyznski.I, Extended release dosage forms, CRS Press, Inc, Florida, 1987
3. Choudhury P.K, Kar M, Preparation of Alginate gel beads containing Metformin Hydrochloride using Emulsion Gelation method, Tropical Journal of Pharmacy and Research, 2005; 4: 489-493.
4. Choudhury PK1, Kar M, Chauhan CS, Cellulose acetate microspheres as a floating depot system to increase gastric retention of Anti-diabetic drug, Formulation and Characterization and In-vitro, In-vivo Evaluation, Drug Dev Indian Pharmacy, 2008; 34: 349-354.
5. Paulo Costa, Modelling and Comparison of Dissolution Profiles, European Journal of Pharma Science, 2001;123-133.
6. Suvakanta Dash, Padala Darasimha Murthy, Lila Kanta Nath, Prasanta Chowdary, Kinetic Modelling on Drug Release from Controlled Drug delivery Systems, AETA Polonia Pharmaceutical Drug Research, 2010; 67(3) : 217-223.
7. Maya Sharma, P.K. Choudhury, S.K. Dev, Formulation of Sodium Alginate Beads by Emulsion Gelation Method, Asian Journal of Pharmaceutics, 2017; 11: 101-106.
8. Sahoo S.K, Mohapatra. S, Dhal S.K, Behera BC, Barik BB, Formulation of Floating Microspheres of Ciprofloxacin Hydrochloride by cross-linking agent,Indian Journal of Pharmacy, 2007; 6(58) : 65-68.
9. Nagasamy Venkatesh. D, Ramesh N, Karthick. S, Mohammed Fakrudeen K, Uthayakumar B, Valliappan R.M, Vinudeepak S, Biplal Debnath, Samanta MK, Suresh B, Design and In-Vitro Evaluation of Alginate beads of Amboroxol Hydrochloride, Journal of Pharmacy Research, 2008; 1(2) : 139-142.
10. Peeush Singhal, Kapil Kumar, Manisha Panday, Shubhini A Saraf, Evaluation of Acyclovir loaded oil entrapped Calcium alginate bead prepared by Ionotropic Gelation method, International Journal of ChemTech Research, 2010; 2(4): 2076-2085.
11. Lena M.T,Yehia IK, Evaluation of Atenolol floating beads as a Controlled Delivery System, Irari Journal of Pharmaceutical Science, 2011; 20(1) : 70-80.
12. Rajamanickam. D, Rajappan M, Varadharajan M, Srinivasan B, Formulation and Evaluation of Albumin Microspheres containing Aceclofenac, IJPSRR,2010; 4(1) :112-117.
13. Wang. J, Flanagan DR, General Solution for Diffusion Controlled Dissolution of Spherical particle, Journal of Pharmaceutical Sciences, 1999; 88(7) : 731-738