Author(s): Bhanu Biswas, Manish Kumar, Jai Bharti Sharma, Vipin Saini, Shailendra Bhatt

Email(s): shailu.bhatt@gmail.com

DOI: 10.5958/0974-360X.2020.00320.0   

Address: Bhanu Biswas1, Manish Kumar1, Jai Bharti Sharma1, Vipin Saini2, Shailendra Bhatt1*
1M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala.
2Maharishi Markandeshwar University, Solan, Himachal Pradesh.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
A new and simple technique of RP-HPLC was developed and validated for the estimation of Teneligliptin in the tablet dosage form. The partition or separation was accomplished on Kromasil C18 analytical column (150 mm × 4.6 mm, 5.0 µm) utilizing acetonitrile, water and trifluoroacetic acid as mobile phase A and acetonitrile and trifluoroacetic acid as mobile phase B at a flow rate of 1.0 ml/min. The detector used in the present study was UV detector and detection was detected at 245nm. The total chromatographic analysis time per sample was about 55.0 min with teneligliptin eluting at the retention time of about 11.2 minutes. The standard curve was found to be linear in the concentration range of 50-150µg/mL with R2 value of 0.999. The developed method was validated for different parameters like accuracy, precision, specificity and linearity. The developed RP-HPLC method was found to be simple, specific, rapid, reliable and reproducible.


Cite this article:
Bhanu Biswas, Manish Kumar, Jai Bharti Sharma, Vipin Saini, Shailendra Bhatt. Method Development and Validation for Estimation of Teneligliptin in Tablet Dosage Form by RP-HPLC. Research J. Pharm. and Tech. 2020; 13(4):1774-1778. doi: 10.5958/0974-360X.2020.00320.0


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