Author(s): C. Ayyanna, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha

Email(s): ayyannac5@gmail.com

DOI: 10.5958/0974-360X.2020.00318.2   

Address: C. Ayyanna*, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha
Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
Aim: To evaluation of anticonvulsant and antioxidant activity of Flacourtia indica on Pentylenetetrazole (PTZ) induced convulsions in mice Methods: Present study animals are divided into 4 groups of albino mice (n=6) were used. The First group was received as control, second group as standard (diazepam, 4mg/kg); third to fifth groups were treated with ethanol extract Flacourtia indica (100, 200 and 400mg/kg). After 30 min of administration ethanolic extract of Flacourtia indica, in mice I. P injection of PTZ (75mg/kg). Anticonvulsant activity was determined by measuring the Latency, Jerky movements, Straub’s tail, Clonic convulsions and Death/Recovery of animals in PTZ induced convulsions in mice. Results: In PTZ model, Flacourtia indica ethanolic extract at a dose of 400mg/kg prolonged latency and onset to seizure activity compared to 100 and 200 mg/kg. Conclusion: Flacourtia indica possess anticonvulsant effect as they delay the latency of seizures produced by PTZ.


Cite this article:
C. Ayyanna, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha. Evaluation of Anticonvulsant and Antioxidant Activity of Flacourtia indica on Pentylenetetrazole (PTZ) Induced Convulsions in Mice. Research J. Pharm. and Tech. 2020; 13(4):1762-1766. doi: 10.5958/0974-360X.2020.00318.2


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