C. Ayyanna, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha
C. Ayyanna*, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha
Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, India.
Volume - 13,
Issue - 4,
Year - 2020
Aim: To evaluation of anticonvulsant and antioxidant activity of Flacourtia indica on Pentylenetetrazole (PTZ) induced convulsions in mice Methods: Present study animals are divided into 4 groups of albino mice (n=6) were used. The First group was received as control, second group as standard (diazepam, 4mg/kg); third to fifth groups were treated with ethanol extract Flacourtia indica (100, 200 and 400mg/kg). After 30 min of administration ethanolic extract of Flacourtia indica, in mice I. P injection of PTZ (75mg/kg). Anticonvulsant activity was determined by measuring the Latency, Jerky movements, Straub’s tail, Clonic convulsions and Death/Recovery of animals in PTZ induced convulsions in mice. Results: In PTZ model, Flacourtia indica ethanolic extract at a dose of 400mg/kg prolonged latency and onset to seizure activity compared to 100 and 200 mg/kg. Conclusion: Flacourtia indica possess anticonvulsant effect as they delay the latency of seizures produced by PTZ.
Cite this article:
C. Ayyanna, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha. Evaluation of Anticonvulsant and Antioxidant Activity of Flacourtia indica on Pentylenetetrazole (PTZ) Induced Convulsions in Mice. Research J. Pharm. and Tech. 2020; 13(4):1762-1766. doi: 10.5958/0974-360X.2020.00318.2
1. Sander JW, Shorvon SD. Epidemiology of the epilepsies. J. Neurol. Neurosurg. Psychiat. 1996, 61, 433-443.
2. Dichter M. Basic mechanisms of epilepsy: targets for therapeutic intervention. Epilepsia 1997; 38 (Suppl. 9): S2– S6.
3. Rang HP, Dale MM, Ritter JM, Moore PK, Pharmacology. Churchill Livingstone, Edinburgh 2007.
4. Richens A, Perucca E. Clinical pharmacology and medical treatment. In: Laidlaw J, Richens A, Chadwick, D. (Eds.), A Textbook of Epilepsy. Churchill Livingstone, Edinburgh 1993: 495–560.
5. Mikael E. Pedersen, Henrik T. Vestergaard, Suzanne L. Hansen, Sekou Bah, Drissa Diallo, Anna K. Jäger. Pharmacological screening of Malian medicinal plants used against epilepsy and onvulsions. Journal of Ethnopharmacology 2009; 121: 472–475.
6. Mokady SH, Dolev A. J Sci Food Agric, 1970; 21: 211–4.
7. Dhanasekaran.; Sivaraman. and Palayan, M. E-Journal of Chemistry, 7(4), 2010, 1555-1561. 37: S4–S11.
8. Shah AS, Wakade AS, Juvekar AR. Immunomodulatory activity of methanolic extract of Murrayakoenigii (L) Spreng. Leaves. Indian J Exp Biol 2008; 4:505-09.
9. Ohkawa H, Ohishi N, Yagi K 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 35l-358.
10. Sedlak J, Lindsay RH 1968. Estimation of total protein bound and non protein bond sulphydryl group in tissue with Ellman’s reagent. Anal Biochem 25: 192-197.
11. Maynert EW, Klingman GI, Kaji HK. Tolerance to morphine. II. Lack of effects on brain 5-hydroxytryptamine and γ -aminobutyric acid. Nfpkamj Cvnfcp 1962; 135: 296-299.
12. Devi PU, Manocha A, Vohora D. Seizures, antiepileptics, antioxidants and oxidative stress: an insight for researchers. Expert Opin Pharmacother. 2008; 9(18):3169–77.
13. Rasilingam D, Duraisamy S, Subramanian R, Anticonvulsant activity of bioflavonoid gossypin. Bangladesh J Pharmacol. 2009; 4(1):51–4