Recently, extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Recent trends indicate that multiparticulates drug delivery systems are especially suitable for achieving extended release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. Development of Nifedipine Sustained Release pellets by Fluidized Bed Processing technology. The different trials were formulated and evaluated for its percent Cumulative drug release, percent Swelling index and scanning electron microscopy. The release of drug from pellets depends on a variety of factors including the carrier used to form pellets and the amount of drug contained in them. In these, trial 2 is Shows better results Such as, percent Cumulative Drug Release is 84.34%, and Scanning Electron Microscopy study shows Pellets uniformities and Spherical shape particle’s also less Agglomeration.
Cite this article:
Rupam A. Wagh, Rajendra K. Surawase. Formulation and Development of Sustained Release Pellets of Nifedipine by Fluidized Bed Processor. Research J. Pharm. and Tech. 2020; 13(4):1757-1761. doi: 10.5958/0974-360X.2020.00317.0
1. Yadav Niti, Lohani Alka. Formulation and Development of Multiparticulate Dosage Form of Propranolol Hydrochloride. Journal of Young Pharmacist.2014; 6(1): 15-21.
2. Instruction Manual Mini Quest-F, Loknete Dr. J.D. Pawar College of Pharmacy, Manur (Nashik), Batch No.-MF 005, Sr. No.- M005F.
3. Gharge Vikram, Sharma Peeyush, Gonjari Indrajeet. Multiple-Unit Controlled Release Platform Formulation by Wruster Process. International Journal of Pharmacy and Pharmaceutical Science, 2014; 6(2): 107-113.
4. Indian Pharmacopeia Government of India, Ministry of Health and Family Welfare, Indian Pharmacopeia Commission, Ghaziabad; 2014; (III): 2338.
5. Akelesh T., Perla S., Vyankatnarayanan R. Formulation and Evaluation of Nifedipine Sustained Release pellets. International Research Journal of Pharmacy. 2011; (2) 8: 177-180.
6. K. Anusha, Mr. G. Kishorbabu. Formulation of Sustained Release Pellets of Quetiapine fumarate By Fluidized Bed Coating Process. International Journal of Pharmaceutical Science Invention. 2013; 2(12): 20-33.
7. T. Nagendra Babu, K. Umashankar. Formulation and Development of Nicardipine Hydrochloride Sustained Release Pellets. International Journal of Innovative Pharmaceutical Sciences and Research. 2015; 3(3): 164-175.
8. Gandhi Bipine R., Badgujar Bhatu P. Development and In-vitro Evaluation of Multiparticulates System Using Novel Coating Material for Controlled Drug Delivery System. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(3): 96-99.
9. Lucian Franquelingomes de Souza. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. Hindawi Publishing Corporation Biomed Research International, 2014; 1-11.
10. Ratnaparkhi M. P., Guptajyoti P, Sustained Release Oral Drug Delivery System, An Overview. International Journal of Pharmacy Research and Review, 2013; 2(3): 11-21.
11. Gandhi Bipine R., Baheti Jagdish. Development and In-vitro Evaluation of Multiparticulates System Using Novel Coating Material for Controlled Drug Delivery System. International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 3(3): 96-99.
12. Khan Anwar, Malviya Rishabha, Sharma Pramod. Multi Unit Drug Delivery System – A Brief Review of Pelletization Technique. World Applied Sciences Journal, 2014; 31(12): 2137-2140.
13. Gavali Harshal, Nair Divya, Patel Dhanik, Multiparticulate drug delivery system and their processing techniques. World Journal of Pharmaceutical Research, 2015; 4(6): 1949-1960.
14. Pathikkumar Maravaniya J., Deshpande Tanvee M., Shinde Rohit V., Multiple Unit Pellet System – A New Path for Drug Delivery, International Journal of Universal Pharmacy and Bio Sciences, 2013; 2(4): 401-415.
15. Gharge Vikram, Sharma Peeyush, Gonjari Indrajeet. Multiple-Unit Controlled Release Platform Formulation by Wruster Process. International Journal of Pharmacy and Pharmaceutical Science, 2014; 6(2): 107-113.