Author(s): Komal S. Lavhate, Rahul S. Solunke, Kore K. J., Rajkumar V. Shete, Madhuri T. Deshmukh

Email(s): kslavhate16@gmail.com , srs1986@yahoo.com

DOI: 10.5958/0974-360X.2020.00315.7   

Address: Komal S. Lavhate1, Rahul S. Solunke1, Kore K. J.2, Rajkumar V. Shete3, Madhuri T. Deshmukh4
1Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, MS India.
2Department of Microbiology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, MS India.
3Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, MS India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020


ABSTRACT:
Mesalamine Microsphere prepared by Ionic Gelation Technique by using sodium alginate and pectin as a release modifier and calcium chloride as a cross linking agent. In this formulation Eudragit-S-100 use a coating polymer that helps to releasing the drug at targeted site. The particle size of prepared Microsphere is less than 200µm that evaluated by the Scanning Electron Microscopy. The Mesalamine Microsphere has other characterization is in the term of Percentage Yield, Entrapment Efficiency, P- XRD, Differential Scanning Colorimetry, FT-IR and the In-vitro drug release. The In-vitro release pattern of Mesalamine studied in pH 7.4 phosphate buffers as 900ml media using USP dissolution apparatus II. The F3 batch of the formulation showed maximum release that is 99.75% at maximum time 9 Hrs. that is due to using pectin polymer that helps to retared the drug release at targeted site over the other formulation. F3 formulation showed better flow characterization by the term of Micromeritic Properties.


Cite this article:
Komal S. Lavhate, Rahul S. Solunke, Kore K. J., Rajkumar V. Shete, Madhuri T. Deshmukh. Development and Characterization of Mesalamine Microsphere for Colon Specific Drug Delivery. Research J. Pharm. and Tech. 2020; 13(4): 1747-1751. doi: 10.5958/0974-360X.2020.00315.7


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