Author(s): Taghreed M. Musa, Zaizafoone N. Nasif, Mahmoud Najim Abid Al-jibouri


DOI: 10.5958/0974-360X.2020.00313.3   

Address: Taghreed M. Musa, Zaizafoone N. Nasif, Mahmoud Najim Abid Al-jibouri
Mustansiriyah University, Department of Science, College of Chemistry, Baghdad.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2020

The new derivatives of heterocyclic resulting, studying spectral Cobalt(II), Nickel(II), Copper(II), and Cadmium (II) with new tridentate ligand namely [3-{1-acetyl-4-[4- (dimethylamino)phenyl]-1H-pyrazol-3-yl}-4-hydroxy-6-methyl-5,6-dihydro-2H-pyran-2-one] which was formed by the (E)-3-(3-(4-(dimethylamino) phenyl)acryloyl)-4-hydroxy-6-methyl- 2H-pyran-2-one with excess of hydrazine monohydrate in glacial acetic acid. NMR, FTIR, MS spectra as well as the elemental analyses, identified the new ligand and TLC was carried out to confirm their structures. The Cobalt (II), Nickel (II), Copper (II) and Cadmium (II) were precipitated by direct reactions of their chlorides with the solution of the ligand in 2:1 molar ratios. All complexes have been identified on the basis of the preliminary analysis, infrared, ultraviolet spectra of the visible moments of magnetic conductivity measurements were conducted for radiation conclude the octahedral geometry around Cobalt (II), Copper (II), and Nickel (II). The Cadmium (II) complex was investigated as tetrahedral in 1:1 ratio. The biological activity of the ligand and its metal complexes in DMSO against some bacterial strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and P. aeruginosa). Effected of the syntheses of HL ligand, [Co(L)2] and [Cu(L)2] complexes were studied on Acetylcholinesterase (AChE) in healthy human serum. Results indicated that all of the compounds displayed moderate and selective AChE inhibitory activity. The complexes of [Cu(L)2] and [Co(L)2] showed inhibition constant in the range (Ki: 8.333×10-4, 3.159×10-12, 2.5×10-6, 3.333×10-4 M respectively) higher than HL ligand (1.1×10-4, 1.964×10-12 respectively) M for AChE.

Cite this article:
Taghreed M. Musa, Zaizafoone N. Nasif, Mahmoud Najim Abid Al-jibouri. Synthesis, Structural and Biological Studies of Some Metal Complexes derived from Tridentate Pyrazole-based Ligand. Research J. Pharm. and Tech. 2020; 13(4):1735-1743. doi: 10.5958/0974-360X.2020.00313.3

1.    C.-Y. Wu, Y. Chen, S.-Y. Jing, C.-S. Lee, J. Dinda and W.-S. J. P. Hwang, 2006, 25, 3053-3065.
2.    P. K. Sharma, S. Kumar, P. Kumar, P. Kaushik, D. Kaushik, Y. Dhingra and K. R. J. E. j. o. m. c. Aneja, 2010, 45, 2650-    2655.
3.    P. A. S. Oliveira, L. M. Sartori, N. A. Rey, H. F. Dos Santos, M. A. L. De Oliveira and L. A. S. J. J. o. t. B. C. S. Costa, Journal, 2013, 24, 1732-1738.
4.    J.  R. Cheeseman, G. W. Trucks, T. A. Keith and M. J. J. T. J. o. c. p. Frisch, 1996, 104, 5497-5509.
5.    B.  Kupcewicz, K. Sobiesiak, K. Malinowska, K. Koprowska, M. Czyz, B. Keppler and E. J. M. C. R. Budzisz, 2013, 22, 2395-2402.
6.    A. Özdemir, G. Turan-Zitouni, Z. Asım Kaplancıklı, G. Revial, F. Demirci, G. J. J. o. e. i. İşcan and m. chemistry, 2010, 25, 565-    571.
7.    E. Brantley, S. Antony, G. Kohlhagen, L. Meng, K. Agama, S. F. Stinson, E. A. Sausville, Y. J. C. c. Pommier and pharmacology, 2006, 58, 62-72.
8.    S. Wang, W. Shao, H. Li, C. Liu, K. Wang and J. J. E. j. o. m. c. Zhang, 2011, 46, 1914-1918.
9.    F. Kratz, B. Nuber, J. Weiss and B. J. P. Keppler, 1992, 11, 487-498.
10.    K. Sakai, Y. Tomita, T. Ue, K. Goshima, M. Ohminato, T. Tsubomura, K. Matsumoto, K. Ohmura and K. J. I. C. A. Kawakami, 2000, 297, 64-71.
11.    T.-H. Yang, A. R. Silva and F.-N. J. D. T. Shi, 2013, 42, 13997-14005.
12.    A. Maher F. and M. N. Abid, Malyasian J. Sci. 2019.38(3), 59_71.
13.    W. J. J. C. C. R. Geary, 1971, 7, 81-122.
14.    Ellman GL, Courtney KP, Andres V,Feather Stone RM. Biochem. Pharmacol.1961 ;( 7):88-95.
15.    N. J. I. J. o. B. R. Zaizafoon and Review, 2015, 7, 100-111.
16.    Ž. K. Jaćimović, V. Leovac, K. Mészáros Szécsényi, J. A. Howard and I. J. A. C. S. C. C. S. C. Radosavljević Evans, 2004, 60, m467-m470.
17.    S. C. Davies, M. C. Durrant, D. L. Hughes, A. Pezeshk and R. L. J. J. o. C. R. Richards, 2001, 2001, 100-103.
18.    K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds (Part A: Theory and Applications in  Inorganic Chemistry) (Volume 1A) (Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry) (Volume 1B), NY, John Wiley & Sons, Incorporated, 1997.
19.    R. C. Maurya and D. D. J. T. M. C. Mishra, 1987, 12, 551-552.
20.    J. E. Huheey, E. A. Keiter, R. L. Keiter and O. K. Medhi, Inorganic chemistry: principles of structure and reactivity, Pearson Education India, 2006.
21.    Greenwood and A. Earnshaw Butterworth –Heinemann, Chemistry of the elements, Oxford, 1997.
22.    D. Sutton, Electronic spectra of transition metal complexes: an introductory text, McGraw-Hill, 1968.
23.    M. S Katlin, V. M. Leovac, R Petkovic, Z. K. Jacimovic and G. Pokol, Therm. Analys. Calorim.2007,3,899-902
24.    S. Konar, A. Jana, K. Das, S. Ray, S. Chatterjee, J. A. Golen, A. L. Rheingold and S. K. J. P. Kar, 2011, 30, 2801-2808.
25.    B. H. Pearce, H. F. Ogutu and R. C. J. E. J. o. I. C. Luckay, 2017, 2017, 1189-1201.
26.    M. F. J. J. o. O. P. Sugrue and Therapeutics, 1996, 12, 363-376.
27.    S. Sumalan, J. Casanova, G. Alzuet, J. Borras, A. Castineiras and C. J. J. o. i. b. Supuran, 1996, 62, 31-39.
28.    C. T. J. M.-b. d. Supuran, 1995, 2, 327-330.
29.    J. Borràs, T. Cristea and C. T. J. M. G. M. C. Supuran, 1996, 19, 339-346.
30.    G. Mincione, A. Scozzafava and C. T. J. M.-b. d. Supuran, 1997, 4, 27-34.
31.    N. Büyükkidan, B. Büyükkidan, M. Bülbül, R. Kasimoğullari, M. Serdar, S. J. J. o. P. Mert and Pharmacology, 2013, 65, 363-369.

Recomonded Articles:

Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

DOI: 10.5958/0974-360X.2017.00425.5         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): G. Bhavani, R. Navaneethan

DOI: 10.5958/0974-360X.2017.00269.4         Access: Open Access Read More

Author(s): Karishma Ravinthar, Jayalakshmi

DOI: 10.5958/0974-360X.2018.00148.8         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): Rahar Sandeep, Nagpal Navneet, Swami Gaurav, Arora Manisha, Bansal Suraj, Goyal Sandeep, Singla Shwali, Singh Preeti, Kapoor Reni

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Karthikeson P.S , Gayathri.R, Vishnu Priya.V

DOI: 10.5958/0974-360X.2016.00289.4         Access: Open Access Read More

Author(s): H. Firdus Fareen, M.S. Thenmozhi

DOI: 10.5958/0974-360X.2016.00146.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles