Ankul Singh S, Gowri K, Chitra V
Ankul Singh S, Gowri K, Chitra V
Department of Pharmacology, S.R.M. College of Pharmacy, SRMIST, Kattankulathur-603203, District- Kancheepuram (T.N.) India.
Volume - 13,
Issue - 3,
Year - 2020
Aerva lanata species belonging to Amaranthaceae family (a.k.a mountain knot grass/ Gorakha Ganga is a perennial shrub. It is self-pollinating, bisexual plant having globose like structure has various phytochemical constituents. Among the 28 species of Aerva, medicinal properties are likely to be present in Aerva lanata, Javanica and Persica varieties. Traditionally it was used in treating cough, dysuria, hemiplegic migraine and kidney related disorders. Flavonoid glycosides such as Kaempferol, Isorhamnetin, quercetin, flavanone are major phytoconstituents and minor constituents are apigenin, narcissin, ferulic acid, syringic acid and vanillic acid. Alkaloid glycoside includes Ervine, aervine etc. Aerva lanata has much more beneficial activities like demulcent, diuretic, ulcer wounds, rheumatism, Anti-malarial. Pharmacological studies included that aerva species has beneficial properties of antimicrobial, anti-urolithiasis, antiulcer, anti-asthmatic, acute kidney injury, anti-diarrheal activity, antioxidant, antihyperglycemic, hypolipidemic and antiulcer. Aerva lanata has promising role in the treatment of various diseases and metabolic disorders due to its higher antioxidant effect and other such constituents thereby providing better healthcare. Various such constituents are to be analyzed properly and to ensure that it was suffice to exhibit the pharmacological activity. Analytical methods are to be used promptly to find various concentration of substances present in the alcoholic extract of Aerva lanata plant.
Cite this article:
Ankul Singh S, Gowri K, Chitra V. A Review on Phytochemical Constituents and Pharmacological Activities of the plant: Aerva lanata. Research J. Pharm. and Tech 2020; 13(3):1580-1586. doi: 10.5958/0974-360X.2020.00286.3
Ankul Singh S, Gowri K, Chitra V. A Review on Phytochemical Constituents and Pharmacological Activities of the plant: Aerva lanata. Research J. Pharm. and Tech 2020; 13(3):1580-1586. doi: 10.5958/0974-360X.2020.00286.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-91
1. Sharma A, Sharma SC, Vaghela JS. Phytopharmacological investigation of Aerva lanata flowers with special emphasis on diuretic activity. Pharmacognosy Journal. 2010; 2(17): 59-62.
2. Sundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian Journal of Experimental Biology.2006; 44(12): 981-986.
3. Sharma A Tarachand, Tanwar M, Nagar N, Sharma AK. Analgesic and anti-inflammatory activity of flowers extract of Aerva lanata. Advances in Pharmacology and Toxicology. 2011; 12(3): 13-18.
4. Chowdhury D, Sayeed A, Islam A, Shah Alam Bhuiyan M, Astaq Mohal Khan GR. Antimicrobial activity and cytotoxicity of Aerva lanata. Fitoterapia. 2002; 73(1): 92-94
5. Deshmukh TA, Yadav BV, Badole SL, Bodhankar SL, Dhaneshwar SR. Antihyperglycemic activity of alcoholic extract of Aerva lanata (L.) A.L. Juss. Ex. J.A. Schultes leaves in alloxan induced diabetic mice. Journal of Applied Biomedicine. 2008; 6(2): 81-87.
6. Shirwaikar A, Issac D, Malini S. Effect of Aerva lanata on cisplatin and gentamycin models of acute renal failure. Journal of Ethnopharmacology. 2004; 90(1): 81-86.
7. Ramachandra YL, Shilali K, Ahmed M, Sudeep HV, Kavitha BT, Gurumurthy H, et al. Hepatoprotective properties of Boerhaavia diffusa and Aerva lanata against carbon tetra chloride induced hepatic damage in rats. Pharmacology online 2011; 3: 435-441.
8. Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J, Duraisamy R, Karthikeyan D, et al. Hepatoprotective activity of Aerva lanata Linn. against paracetamol induced hepatotoxicity in rats. Research J Pharm and Tech 2008; 1(4): 398- 400.
9. Rajesh R, Chitra K, Paarakh PM. In vitro anthelmintic activity of aerial parts of Aerva lanata Linn Juss. International Journal of Pharmaceutical Sciences and Drug Research. 2010; 2(4):269-271.
10. Singh S, Rai AK, Sharma P, Singh PA. Antidiarrheal activity of Aerva lanata in experimentally induced diarrhea in rats. Pharmacology online.2011; 2: 921-928.
11. Nagal A, Singla RK. Herbal resources with antiurolithiatic effects: a review. Indo Global Journal of Pharmaceutical Sciences.2013; 3: 6-14.
12. Patel PK, Patel MA, Saralai MG, Gandhi TR. Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad & Wendl. (Solanaceae) against ethylene glycol induced urolithiasis in rats. Journal of Ethnopharmacology. 2012; 144: 160-70.
13. Bhattacharjee A. Phytochemical and ethno-pharmacological profile of Crataeva nurvala Buch-Hum (Varuna): a review. Asian Pacific Journal of Tropical Biomedicine. 2012;2: 1162-8.
14. Makasana Atul, Ranpariya Vishavas, Desai Dishant, Mendpara Jaymin,Parekh Vivek. Evaluation for the anti-urolithiatic activity of Launaea procumbens against ethylene glycol-induced renal calculi in rats. Toxicology Reports. 2014; 1:46-52.
15. Kahl R, Kappus H. Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E. Z Lebensm Unters Forsch.1993; 196(4): 329-338.
16. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity. 2009; 2(5): 270-278.
17. Staruchová M, Volková K, Lajdová A, Mislanová C, Collins A, Wsólová L, et al. Importance of diet in protection against oxidative damage. Neuro Endocrinology Letters. 2006; 27(2): 112-115.
18. Metro D, Muraca U, Manasseri L. Role of green tea in oxidative stress prevention. Clinical Therapeutics.2006; 157(6): 507-510.
19. Aggarwal S, Tandon C, Forouzandeh M, Singla S, Kiran R, Jethi R. Role of a protein inhibitor isolated from human renal stone matrix in urolithiasis. Indian Journal of Biochemiatry and Biophysics.2005; 1:113-7.
20. Sujoy Banerjee.Potential clinical significance of urease enzyme. European Scientific Journal. 2013;9(21):94-102.
21. Chaitanya, D. & kumar, M. & Reddy, A. & Mukherjee, & Sumanth, & Ramesh, DR. Anti urolithiatic activity of Macrotyloma uniflorum seed extract on ethylene glycol induced urolithiasis in albino rats. Journal of Innovative Trends in Pharmaceutical Sciences.2010;1.
22. Manoj Goyal, Anil Pareek, B.P Nagori and D. Samal, Aerva lanata: a review on phytochemistry and pharmacological aspects, pharmacognosy review 2011; 5: 195-198.
23. Aruna Adepu, Sagar Naral, Ashok Ganji and Sapnil Chilvalvar,a review on natural plant:Aerva lanata. International journal of pharmascience.2013;3:398-402.
24. Kirtikar KP, Basu BD, Mahaskar C. Indian Medicinal Plants. 2nd ed. Allahabad: International Book Distributors; 1987. p. 2051.
25. Harborne JB. Phytochemical methods. A guide to modern techniques of plant analysis. 3rd ed. London: Chapman and Hall. Springer Netherlands.1998. P.XIV, 302.
26. B. Arirudran, V. Krishnan, Us Mahadeva Rao. Preliminary Phytochemical Analysis and Isolation and Identification of active principle components of petroleum ether extract from leaves of Lawsoniainermis L. Research J. Pharm. and Tech. 2019; 12(8): 3629-3636.
27. Guha G, Rajkumar V, Ashok Kumar R, Mathew L. Aqueous extract of Phyllanthus amarus inhibits chromium (VI)-induced toxicity in MDA-MB-435S cells. Food and Chemical Toxicology. 2010; 48(1): 396-401.
28. Singleton, V. L., Orthofer, R., & Lamuela-Raventos, R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent.Methods in Enzymology.1999;299:152-178.
29. Sakakibara H, Honda Y, Nakagawa S, Ashida H, Kanazawa K. Simultaneous determination of all polyphenols in vegetables, fruits, and teas. Journal of Agriculture and Food Chemistry.2003; 51(3): 571-581.
30. J. Xing, C.F. Xie, H.X. Lou, Recent applications of liquid chromatography-mass spectrometry in natural products bioanalysis, Journal of Pharmaceutical and Biomedical Analysis. 2007;4: 368–378.
31. Yamunadevi M., Wesely EG., Johnson M., Phytochemical studies on the terpenoids of medicinally important plant Aerva lanata L. using HPTLC Asian Pacific Journal of Tropical Biomedicine (2011) S220-S225.
32. Zapesochnaya G, Kurkin V, Okhanov V, Miroshnikov A. Canthin6-one and ß-carboline alkaloids from Aerva lanata. Planta Medica.1992; 58:192-6.
33. Zapesochnaya GG, Kurkin VA, Okhanov VV, Perzykh LN, Miroshnilov AI. Structure of the alkaloids of Aerva lanata. Chemistry of Natural Compounds.1991; 27:725-8.
34. Zapesochnaya GG, Pervykh LN, Kurkin VA. A study of the herb Aerva lanata. III. Alkaloids. Chemistry of Natural Compounds.1991; 27:336 40.
35. Ahmed E, Imran M, Malik A, Ashraf M. Antioxidant activity with ﬂavonoidal constituents from Aerva persica. Archives of Pharmacy and Research. 2006; 29:343-7.
36. Pervykh LN, Karasartov BS, Zapesochnaya GG. A study of the herb Aerva lanata IV. Flavonoid glycosides. Chemistry of Natural Compounds.1992; 28:509-10.
37. Zadorozhnii A.M., Zapesochnaya G.G., Pervykh L.N., Shchavlinskii A.N., Kovtun L.S., Svanidze N.V.: Khim. Farm. Zh. 1986; 20:855.
38. Aboutabl E.A., Wassel G.M., Wahab S.M.A., Ammar N.M., Yassin N.: Egyptian Journal of Pharmaceutical Sciences. 1997; 38:38.
39. Mallakaev A., Rakhimov D.A., Murdakhaev Y.M. Khim. Prir. Soedin.1989; 3:425.
40. Omoyeni OA, Adeyeye EI. Chemical composition, calcium, zinc and phytate interrelationships in Aerva lanata (Linn) Juss. Ex schult leaves. Oriental Journal of Chemistry. 2009; 25:485-8.
41. Kirtikar K.R., Basu B.D.: Indian Medicinal Plants, 2nd edn., Vol. 3, p. 2062, Bishen Singh, New Delhi 1984.
42. Radwan HM, Nazif NM, Hamdy AA. The lipid and flavanoidal constituents of Aerva javonica and its antimicrobial activity. Egyptian Journal of Pharmaceutical sciences.2001; 40: 167-168.
43. Garg, S. P, Bhushan R, and Kapoor, R. C. Aervanone, a new flavonoid from Aerva persica. Phytochemistry. 1980; 19:1265–1267.
44. Gupta R.K, Gaur Y.D, Malhotra S.P, Dutta B.K. Medicinal plants of the Indian arid zone. Journal of Tropical Agriculture and applied botany.1966; 13:250.
45. Chopra R.N.: Indigenous Drugs of India. p. 50, Art Press, Calcutta 1933.
46. Priya CL, Kumar G, Karthik L, Rao KVB. Antioxidant activity of Achyranthes aspera Linn stem extracts. Pharmacology online 2010; 2: 228-237.
47. Mamatha Mohan, V Veena, K Ramakrishna Reddy. Synthesis, Characterization and Study of Cytotoxicity, Antioxidant properties of Isatin based mixed Ligand Complexes. Research J. Pharm. and Tech 2019; 12(8):3945-3950.
48. Dinis TC, Maderia VM, Almeida LM. Action of phenolic derivatives (acetaminophen, salicylate and 5-amino salicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Archives of Biochemistry and Biophysics.1994; 315(1): 161-169.
49. Oyaizu M. Studies on products of browning reactions: Antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese journal of Nutrition and Dietetics. 1986; 44: 307-315.
50. Sahana Chavan C. S, Ramakrishna Rao, Saraswathi Raman D. N, Somashekaraiah B. V. Phytochemical Analysis and In vitro Antioxidant activity of extracts of Justicia wynaadensis leaves. Research J. Pharm. and Tech 2019; 12(8):3643-3648.
51. Vetrichelvan T, Jegadeesan M, Senthil Palaniappan M, Murali NP, Sasikumar K. Diuretic and antiinﬂammatory activities of Aerva lanata in rats. Indian Research Journal of Pharmacy. 2000; 62:300-2.
52. Appia krishnan G,Ravi V K,Nandy B C,Meena K C,Dey S,Tyagi P K,Tyagi L K.Hypoglycemic and anti-hyperlipidaemic effect of ethanolic extract of aerial parts of Aerva lanata linn.in normal and alloxan induced diabetic rats. International journal of pharmaceutical science and drug research. 2009;1(3),191-194.
53. Jagtap NS, Khadabadi SS, Ghorpade DS, Banarase NB, Naphade SS. Antimicrobial and Antifungal Activity of Centella asiatica (L.) Urban, Umbeliferae. Research J. Pharm. and Tech 2009; 12(8):22328-22330.
54. A. Anita and Malar Retna, The preview on medicinal plant: Aerva lanata. Asian journal of bio chemical and pharmaceutical research.2013:3.
55. Ragavendran P, Arul raj C, Sophia D, Starlin T and Gopalakrishnan V.K, Elemental analysis of Aerva lanata (l) by Energy dispersive X-ray spectroscopy. International research journal of pharmacy.2012; 7:218-220.
56. Desh Deepak Singh. Assessment of Antimicrobial activity against clinical isolates of human pathogen, Physiochemical and Phytochemical Analysis of Lantana indica Roxb. Research J. Pharm. and Tech 2019; 12(8):3873-3877.
57. Vetrichelvan T, Jegadeesan M, Senthil Palaniappan M, Murali NP, Sasikumar K. Diuretic and antiinﬂammatory activities of Aerva lanata in rats. Indian Research Journal of Pharmacy. 2000; 62:300-2.
58. Majmudar F.I., Shah M.B., Patel K.N., Shah B.K. Pharmaceutical, Ethnopharmacological, Phytochemical and Synthetic Importance of Genus Aerva: A Review. Indian Journal of Natural Product. 1999; 15:9-12.
59. Uduphille M., Jiffry M.T.M.: a review of chemistry and biological activities of the genus Aerva- a desert plant. Indian Journal of Physiology and Pharmacology.1981;30:91.
60. Nevin KG, Vijayammal PL. Pharmacological and immunomodulatory effects of Aerva lanata in daltons lymphoma ascites-bearing mice. Pharm Biol 2005; 43:640-6.
61. Nevin KG, Vijayammal PL. Effect of Aerva lanata on solid tumor induced by DLA cells in mice. Fitoterapia 2003; 74:578-82.
62. Gayathiri. N. M, Sudhakar P, Manimekalai P, Sabarinath C. In Vitro Anti-helminthic Activity of hydroalcoholic extract of Martynia annua L. and Pentanema indicum. Research J. Pharm. and Tech 2019; 12(8):3847-3850.
63. Anantha D, Israiel Kumar T, Santosh Kumar M, Manohar Reddy A, Mukharjee NS, Lakshmana Rao A. In vitro anti helmentic activity of aqueous and alcoholic extracts of Aerva lanata seeds and leaves. J Pharm Sci Res 2010; 2:317-21.
64. Kumar D, Prasad DN, Parkash J, Bhatnagar SP. Antiasthmatic activity of ethanolic extract of Aerva lanata Linn. Pharmacologyonline 2009; 2:1075-81.
65. Savadi R, Alagawadi K. Antifertility activity of ethanolic extracts of plumbago indica and Aerva lanata on albino rats. Int J Green Pharm 2009; 3:230-3.
66. Saleh NA, Mansour RM, Markham KR. An acylated isorhamnetin glycoside from Aerva javanica. Phytochemistry 1990; 29:1344-5.
67. Athira P et al. Pharmacognostic Review of Medicinal Plant Aerva lanata Journal of pharmaceutical sciences and Research.2017; 9(9):1420-1423.
68. Vetrichelvan T, Jegadeesan M. Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats. Journal of Ethnopharmacology.2002; 80:103-7.
69. Flowerlet Mathew, Bimi Varghese, Dhanish Joseph, Manju Maria Mathews, Betsy Sunny, Junia George. An Appraisal of Pharmacological actions of Morus indica: The Indian mulberry with a detailed investigation on its Anti-diabetic potential. Research J. Pharm. and Tech 2019; 12(8):3654-3658.
70. Mammen denni, danial mammen,yellow and white varient of Aerva lanata:a phytochemical variation study. Indian journal of applied research 2013; 3:7.
71. Tristiana Erawati, Dewi Melani Hariyadi, Noorma Rosita, Tutiek Purwanti. The Anti-inflammatory Activity of p-methoxycinnamic acid (PMCA) in the Nanostructured lipid carrier (NLC) system using combinations of solid lipid, beeswax-oleum cacao and liquid lipid, Virgin Coconut oil (VCO). Research J. Pharm. and Tech 2019; 12(8): 3619-3625.
72. Devi P, Merlin NJ, Madhumitha B, Meera R. Wound healing property of Aerva Lanata leaves extract. Research J. Pharm. and Tech 2009; 12(8):21210-21211.
73. Soundararajan P, Mahesh R, Ramesh T, Begum VH. Hypolipidemic activity of Aerva lanata on ethylene glycol induced calcium oxalate urolithiasis in rats. Pharmacology online 2007; 1:557-63.
74. Guha G, Rajkumar V, Mathew L, Kumar RA. The antioxidant and DNA protection potential of Indian tribal medicinal plants. Turkish Journal of Biology.2011; 35(2): 233-242.
75. Yang ZG, Sun HX, Fang WH. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Vaccine 2005; 23(44): 5196-5203.