Author(s): Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat

Email(s): 55vidya42@gmail.com

DOI: 10.5958/0974-360X.2020.00273.5   

Address: Vidya Bhagat*, Nordin Simbak, Rohayah Husain, Khairi Che Mat
University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020


ABSTRACT:
Increased criminality over the globe has led researchers to focus on the various happenings of criminal behavior. The scientific rationale for reduced control of inhibiting antisocial impulses and aggressive behavior, that goes with a variant of the relevant gene such as MAO-A is underactive prefrontal cortex area of the brain. The current study explores past reviews regarding gene expression in criminal behavior. The purpose of this study is to develop an awareness of gene expression in criminal behavior. A literature review conducted using electronic databases for this study, reviewing 30 articles from the year 1970 to 2018. The articles reviewed focused on genetic variation in human aggression, MAOA genotype, and aggression, MAOA promoter activity, a gene (MAOA) predicting behavioral aggression. The study concludes that although MAOA is a promoter of various activity variations, in MAOA can lead to hazardous criminal behaviour. The depth of understanding in this area would bring insights into professionals to rehabilitate criminals on a humanitarian base. The current study suggests there are limited studies in this area, especially in developing countries, thus the government and non-governmental agencies should encourage more researches in this area, which would bring more insight into this area.


Cite this article:
Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat. Review Study - Gene Influence on Hazardous Criminal Behaviors. Research J. Pharm. and Tech 2020; 13(3): 1499-1502. doi: 10.5958/0974-360X.2020.00273.5

Cite(Electronic):
Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat. Review Study - Gene Influence on Hazardous Criminal Behaviors. Research J. Pharm. and Tech 2020; 13(3): 1499-1502. doi: 10.5958/0974-360X.2020.00273.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-78


REFERENCES:
1.    Appelbaum PS, Scurich N. Impact of behavioral genetic evidence on the adjudication of criminal behavior. The journal of the American Academy of Psychiatry and the Law. 2014; 42(1):91.
2.    Mednick SA, Gabrielli WF, Hutchings B. Genetic influences in criminal convictions: Evidence from an adoption cohort. Science. 1984 May 25; 224(4651):891-4.
3.    Coccaro EF, et al., Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Archives of General Psychiatry. 1989 Jul 1; 46(7):587-99.
4.    Higley JD, et al., Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Archives of General Psychiatry. 1996 Jun 1; 53(6):537-43.
5.    Gottfredson MR, Hirschi T: A General Theory of Crime. Stanford, CA: Stanford University Press, 1990.
6.    Moffitt TE: Adolescence-limited and life-course-persistent antisocial behavior – a developmental taxonomy. Psychol Rev 1993; 100: 674– 701.
7.    Popova NK, et al., Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness to man. Aggressive Behavior. 1991; 17(4):207-1
8.    Valzelli L. Serotonergic inhibitory control of experimental aggression. Pharmacological Research communications. 1982 Jan 1; 14(1):1-3.
9.    Troncone LR, Tufik S. Effects of selective adrenoceptor agonists and antagonists on aggressive behavior elicited by apomorphine, DL-dopa and fusaric acid in REM-sleep-deprived rats. Physiology & behavior. 1991 Jul 1; 50(1):173-8.
10.    Nikulina EM, Kapralova NS. Role of dopamine receptors in the regulation of aggression in mice; relationship to genotype. Neuroscience and Behavioral Physiology. 1992 Sep 1; 22(5):364-9.
11.    Tufik S, Lindsey CJ, Carlini EA. Does REM sleep deprivation induce a super sensitivity of dopaminergic receptors in the rat brain? Pharmacology. 1978; 16(2):98-105.
12.    Brown G, et al., Aggression in humans correlates with cerebtospinal fluid amine metabolites. Psychiatry Res. 1979:1-31.
13.    Rakowsky HF. Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A. Science. 1991; 254:679.
14.    Brunner HG, et al.  Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science. 1993; 262(5133):578-80.
15.    Hudson M. Changing genes: Science and being Maori. 2009
16.    Bortolato M, Chen K, Shih JC. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Advanced Drug Delivery Reviews. 2008; 60(13-14):1527-33.
17.    Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002 Aug 2; 297(5582):851-4.
18.    Youdim MB, Edmondson D, Tipton KF. The therapeutic potential of monoamine oxidase inhibitors. Nature Reviews Neuroscience. 2006 Apr; 7(4):295.
19.    J.P. Johnston, Some observations upon a new inhibitor of monoamine oxidase in brain tissue, Biochem. Pharmacol. 17 (1968) 1285–1297.
20.    J. Knoll, K. Magyar, Some puzzling pharmacological effects of monoamine oxidase inhibitors, Adv. Biochem. Psychopharmacol. 5 (1972) 393–408.
21.    Seo D, Patrick CJ, Kennealy PJ. Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders. Aggression and Violent Behavior. 2008 Oct 1; 13(5):383-95.
22.    Godar SC, Fite PJ, McFarlin KM, Bortolato M. The role of monoamine oxidase A in aggression: Current translational developments and future challenges. Progress in neuro-Psychopharmacology and Biological Psychiatry. 2016 Aug 1; 69:90-100.
23.    Inoue K, Lupski JR. Genetics and genomics of behavioral and psychiatric disorders. Current opinion in Genetics & Development. 2003 Jun 1; 13(3):303-9.
24.    Zhu QS, Grimsby J, Chen K, Shih JC. Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. Journal of Neuroscience. 1992 Nov 1; 12(11):4437-46.
25.    Mouse H. Monoamine oxidase A.1993.
26.    Gronek P, Wieliński D, Gronek J. Genetic and non-genetic determinants of aggression in combat sports. Open Life Sciences. 2015; 10(1).
27.    McKusick VA. Online Mendelian inheritance in man, OMIM. Baltimore, MD: McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University, and Bethesda, MD: National Center for Biotechnology Information, National Library of Medicine. (2006).
28.    Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, Gaspar P. Lack of barrels in the somatosensory cortex of monoamine oxidase A–deficient mice: role of a serotonin excess during the critical period. Neuron. 1996; 16(2):297-307.
29.    Gallardo‐Pujol D, Andrés‐Pueyo A, Maydeu‐Olivares A. MAOA genotype, social exclusion and aggression: An experimental test of a gene–environment interaction. Genes, Brain and Behavior. 2013 Feb; 12(1):140-5.
30.    McDermott R, Tingley D, Cowden J, Frazzetto G, Johnson DD. Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation. Proceedings of the National Academy of Sciences. 2009 Feb 17; 106(7):2118-23.
31.    Hook GR. Warrior genes” and the disease of being Māori. Mai Review. 2009; 2:1-1.
32.    Cases O, et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science. 1995 Jun 23; 268(5218):1763-6.
33.    Tiihonen, J., et al. 2015. Genetic Background of Extreme Violent Behavior. Molecular Psychiatry, 20:786-792
34.    Sohrabi S. The criminal gene: The link between MAOA and aggression. In BMC Proceedings 2015 Jan (Vol. 9, No. 1, p. A49). BioMed Central.
35.    Morishima M, et al. Monoamine oxidase A activity and norepinephrine level in hippocampus determine hyper-wheel running in SPORTS rats. Neuropsychopharmacology. 2006 Dec; 31(12):2627-38.

Recomonded Articles:

Author(s): Ismael Hasan Jawad, Kahtan Hadi AL- Jubori, Hasan Alwan Baiee

DOI: 10.5958/0974-360X.2017.00363.8         Access: Open Access Read More

Author(s): Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat

DOI: 10.5958/0974-360X.2020.00273.5         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags