Author(s):
Priyanka Sharma, Parvinder, Saloni Kakkar, Anurag Khatkar
Email(s):
salonikakkar2007@gmail.com
DOI:
10.5958/0974-360X.2020.00265.6 
Address:
Priyanka Sharma, Parvinder, Saloni Kakkar*, Anurag Khatkar
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 3,
Year - 2020
ABSTRACT:
A number of 4-hydroxy-3-methoxy benzoic acid (vanillic acid) compounds were prepared and evaluated for urease inhibition activity. All the prepared compounds were characterized by IR, 1H NMR spectroscopic techniques. Synthesized compounds were screened for Urease inhibition activity against jack bean urease by using indophenols method. Results exposed that compound 3, 14 and 17 with IC50 values of 33.52µg/ml , 32.41 µg/ml and 30.06µg/ml were the most active urease inhibitors comparable to standard thiourea (IC50: 33.50 µg/ml). Hence newly synthesized derivatives of vanillic acid derivatives exhibits considerable urease inhibition potency.
Cite this article:
Priyanka Sharma, Parvinder, Saloni Kakkar, Anurag Khatkar. Synthesis and Urease Inhibition Activity of 4-hydroxy-3-methoxy benzoic acid Derivatives. Research J. Pharm. and Tech 2020; 13(3): 1453-1456. doi: 10.5958/0974-360X.2020.00265.6
Cite(Electronic):
Priyanka Sharma, Parvinder, Saloni Kakkar, Anurag Khatkar. Synthesis and Urease Inhibition Activity of 4-hydroxy-3-methoxy benzoic acid Derivatives. Research J. Pharm. and Tech 2020; 13(3): 1453-1456. doi: 10.5958/0974-360X.2020.00265.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-70
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