ABSTRACT:
In this study the formulation of safe and effective enteric coated matrix tablet of Loperamide was prepared for the effectual treatment of inflammatory bowel diseases. Direct compression method is used for the formulation of colon targeted matrix tablet of Loperamide. Eudragit FS 30 D polymer and Triethyl citrate this coating material is used for this tablet. This coated tablet evaluated for properties such as average weight, hardness and coat thickness. The In vitro release studies of prepared tablets was carried out for 100 rpm for first 2 hrs. Then replaced with 7.4 pH phosphate buffer and continued for 24 hrs. According to United States Pharmacopoeia (USP) limits, the percentage weight variation, percent friability and content of drug molecule for all the formulations are in the range of USP limits. From the results obtained, Loperamide would be a hopeful formulation to achieve the aim which cure inflammatory bowel diseases without any gastric irritation, which is helpful for patients having pre-history of ulcerative colitis.
Cite this article:
Sagar Kadam, Pradip Yadav, Dhananjay Landge. Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide. Research J. Pharm. and Tech 2020; 13(3):1447-1452. doi: 10.5958/0974-360X.2020.00264.4
Cite(Electronic):
Sagar Kadam, Pradip Yadav, Dhananjay Landge. Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide. Research J. Pharm. and Tech 2020; 13(3):1447-1452. doi: 10.5958/0974-360X.2020.00264.4 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-69
REFERENCES:
1.
Allen L, Ansel H
and Jr. Popovich N. Ansel’s Pharmaceutical Dosage Forms and Drug delivery
systems, Baltimore, Md: Lippincott Williams & Wilkins. 8th edition, 2004;
260- 268.
2.
Leon Lachmann,
Herbert A. Liberman, Joseph L Kanig. The Theory and Practice of Industrial
Pharmacy. Varghese Publishing House, Bombay, 3 rd edition, 1998: 171, 201- 213, 285-286, 293, 313-314,
400-456.
3.
Chien Y.W. Novel
Drug Delivery Systems. Revised and Expanded 2nd Editions: 1992: 1-2, 139-140.
4.
Thakkar H, Patel
B, Thakkar S. A Review on Techniques for Oral Bioavailability Enhancement of
Drugs. International Journal of Pharmaceutical Sciences Review and Research.
2010;4(3): 203-223
5.
Shekhawat PB,
Pokharkar VB. Understanding peroral absorption: regulatory
aspects and contemporary approaches to tackling solubility and permeability
hurdles. Acta Pharm Sin B.
2016; 7(3):260-280.
6.
Rao AA, Rao VN ,
SeethaDevi A, Anil K, Naik VV .Oral Controlled Release Drug Delivery System: An
Overview. International Journal of Pharma And Chemical Research.2015; 1(1):
6-15
7.
Sheaikh SS.
Current Technologies for Enhancing Oral Drug Delivery System: A Review.
International Journal of Research in Pharmacy and Biosciences. 2017; 4(10):
1-10
8.
Reddy S, Haritha
P, Bindu EH. Formulation And Evaluation Of Immediate Release Tablets Of
Montelukast Sodium. World Journal of Pharmaceutical Research. 2014; 3(10):
827-845.
9.
Pole S, Maurya S,
Hasnale P, Rathod N, Bendale S, Khutle NM. A Detail Understanding Of Enteric
Coated Tablet: Manufacturing And Evaluation. European Journal of Pharmaceutical
and Medical Research.2016;3(4):135-144.
10. Singh DH, Roychowdhury S, Verma P, Bhandari V. A
review on recent advances of enteric coating. IOSR Journal of Pharmacy. 2012;
(6): 05-11
11. Shareef AM, Khar R, Ahuja A, Ahmad F & Raghava S.
Colonic Drug Delivery: An Updated Review. AAPS PharmSci. 2003; 5. E17.
12. Kalidoss
S, Koumaravelou K. Formulation Development and in vitro-in vivo studies on
Colon Targeted Oral Delivery System of Atorvastatin. Journal of Pharmaceutical
Sciences and Research. 2018;10(9):2401-2406.
13. https://pubchem.ncbi.nlm.nih.gov/compound/Loperamide
14. Aulton M. Pharmaceutics: The Science of Dosage Form
Design. International Student Edition: 304-321, 347-668.
15. Indian pharmacopoeia. The Indian Pharmacopoeia Commission.
Ghaziabad: 2007 Vol.2 p.g 662.
16. Raju D, Padmavathy J, Saraswathi VS, Saravanan D. Formulation
and development of enteric coated tablets of prednisolone as a colon targeted
drug delivery, IJPSR. 2011; 2(3): 685-690.
17. Patil A, Payghan S, Disouza J. Formulation and
Evaluation of Enteric coated tablets of Azithromycin dihydrate, International Journal
of ChemTech Research. 2011; 3(3): 1479-1484.
18. Government of India, Ministry of Health and Family
Welfare. Indian Pharmacopoeia. New Delhi: The Controller of Publication; 2007 :
185-192.
19. Jaiswal M and Lanjhiyana SK: A critical review on
colon targeted drug delivery systems for management of inflammatory bowel
disease. International Journal
Of Pharmaceutical Sciences And Research. 2019; 10(3):
985-992.
20. Amidon S, Brown JE and Dave
VS: Colon-targeted oral drug delivery systems: Design trends and approaches.
AAPS Pharm Sci Tech 2015; 16(4): 731-741.
21. Kumar JR, Muralidharan S,
Dhanaraj SA and Umadevi SK: A novel drug delivery systems of colon targeted: A
review. J Pharm Sci Res 2013; 5(2): 42-47
22. Obot SS. Colon-targeted drug delivery systems: design,
trends and approaches. Universal Journal of Pharmaceutical Research. 2017;
2(4): 53-57.
23. Hideyuka T, Junko N, Junta
K. Enhanced absorption of Insulin and (Asu1, 7) Eel- calcitonin using novel azo
polymer-coated pellets for colon-specific drug delivery." J Pharmaceutical
Sciences. 2001; 90(1): 89-97.
24. Norihito S, Toshihito T, Masumi V. Chitosan dispersed
system for the colon-specific drug delivery. Int J of Pharm. 2002; 245: 45-54.
25. Maestrelli F. Development
of enteric-coated calcium pectinate microspheres intended for colonic drug
delivery. Eur J Pharm Biopharm. 2008; 69: 508-518.
26.
Salve PS. Development and in vitro evaluation colon targeted drug
delivery system using natural gums. Asian J Pharma. Res. 2011; 1(4): 91-101.