Methenamine hippurate is an antibiotic used for the treatment of urinary tract infections but no other types of bacterial infections (such as in the blood) or for viral infections (such as the common cold or flu). Methenamine hippurate acts as an antibiotic that stops the growth of bacteria in urine. Methenamine hippurate helps to make the urine acidic. When the urine is acidic, Methenamine hippurate turns into formaldehyde to kill the bacteria. Four new spectrophotometric methods have been proposed for the estimation of Methenamine hippurate in pharmaceutical formulations using acetate buffer (pH 2.4) and borate buffer (pH 9.0), phosphate buffer (pH 7.0) and phosphate buffer (pH 8.0). Methenamine hippurate has shown absorption maxima at 230 nm in all the methods. Methenamine hippurate obeys Beer-Lambert’s law over the concentration range 10-80 µg/ml in all the methods and all the methods were validated as per ICH guidelines.
Cite this article:
Raghu Raj Naik, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna. New Validated Analytical Methods for the Determination of Methenamine Hippurate (An Antibiotic Agent). Research J. Pharm. and Tech 2020; 13(3):1386-1390. doi: 10.5958/0974-360X.2020.00254.1
Raghu Raj Naik, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna. New Validated Analytical Methods for the Determination of Methenamine Hippurate (An Antibiotic Agent). Research J. Pharm. and Tech 2020; 13(3):1386-1390. doi: 10.5958/0974-360X.2020.00254.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-59
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