K. Bhavyasri, M. Manisha
Dr. K. Bhavyasri1*, M. Manisha2
1Head of Department of Pharmaceutical Analysis, RBVRR Women’s College Of Pharmacy, Barkatpura, Hyderabad, Telangana-500027, India.
2Department of Pharmaceutical Analysis, RBVRR Women’s College Of Pharmacy, Barkatpura, Hyderabad, Telangana-500027, India.
Volume - 13,
Issue - 3,
Year - 2020
A simple, sensitive and reproducible Spectrophotometric method is developed for estimation of Tenofovir Alafenamide Fumarate (TAF) in bulk and its tablet dosage form. Forced degradation studies are also conducted on standard TAF and % degradation of drug under various stress conditions is reported. Different concentrations of TAF are prepared using distilled water: acetonitrile as diluent. The absorption maximum of TAF is found to be at 261nm. Linearity was established in the range of 6.25-37.5 µg/ml with regression coefficient of 0.999. The drug was subjected to acid and alkali hydrolysis, oxidation degradation, thermal and photo degradation conditions.
Cite this article:
K. Bhavyasri, M. Manisha. UV-Spectrophotometric estimation and forced Degradation studies of Tenofovir Alafenamide fumarate (TAF) in its Bulk and Tablet Dosage Form. Research J. Pharm. and Tech 2020; 13(3):1231-1235. doi: 10.5958/0974-360X.2020.00227.9
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