Synthesis and Antioxidnat activity of novel 2-Mercapto Pyrimidine Derivatives

Mumtaz Mohammed Hussain M; D. R. Bharthi; B. C. Revanasiddappa; Hemanth Kumar

doi:10.5958/0974-360X.2020.00225.5

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Synthesis and Antioxidnat activity of novel 2-Mercapto Pyrimidine Derivatives

Author(s): Mumtaz Mohammed Hussain M, D. R. Bharthi, B. C. Revanasiddappa, Hemanth Kumar

Email(s): mumtazmhussain@gmail.com , evergreen_revan@rediffmail.com , hemantkumar@nitte.edu.in

DOI: 10.5958/0974-360X.2020.00225.5

Address: Mumtaz Mohammed Hussain M1, D. R. Bharthi2, B. C. Revanasiddappa3, Hemanth Kumar3
1Associate Professor, Department of Pharmaceutical Chemistry, SJM College of Pharmacy, JMIT Campus, Chitradurga.
2Professor, Department of Pharmacology, SJM College of Pharmacy, Chitradurga.
3Associate Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangaluru.
*Corresponding Author

Published In: Volume - 13, Issue - 3, Year - 2020

View HTML

View PDF

ABSTRACT:
A new series of 2-mercapto pyrimidines (3a-h) were synthesized by the reaction of thiourea with various substituted chalcones (2a-h) and were characterized by IR, 1H-NMR and Mass spectral analysis. The title compounds were tested for In-Vitro antioxidant activity, compounds 3c, 3e have exhibited promising antioxidant activity.

Keywords:

Cite this article:
Mumtaz Mohammed Hussain M, D. R. Bharthi, B. C. Revanasiddappa, Hemanth Kumar. Synthesis and Antioxidnat activity of novel 2-Mercapto Pyrimidine Derivatives. Research J. Pharm. and Tech 2020; 13(3): 1224-1226. doi: 10.5958/0974-360X.2020.00225.5

Cite(Electronic):
Mumtaz Mohammed Hussain M, D. R. Bharthi, B. C. Revanasiddappa, Hemanth Kumar. Synthesis and Antioxidnat activity of novel 2-Mercapto Pyrimidine Derivatives. Research J. Pharm. and Tech 2020; 13(3): 1224-1226. doi: 10.5958/0974-360X.2020.00225.5 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-30

REFERENCES:

1. Navin BP, Hemant RP. Synthesis and pharmacological studies of 5-ethyl pyridin-2-ethanol analogs derivatives. ARKIVOC. 2009; xii: 302-21.

2. Beena KP, Akelesh T. A Novel Series of Dihydropyrimidines as Possible Antimicrobial Agents. Research J. Pharm. and Tech. 4(8): August 2011; Page 1252-1255.

3. Pankaj Kumar, Abhishek Kumar, Jean Sandra pinto, Akshata G, Bhashini. Synthesis and Biological Evaluation of Pyrimidine Derivatives Via Pyrrolyl Chalcones. Research J. Pharm. and Tech. 2017; 10(5): 1392-1394.

4. Ramachandran S, Vijey Aanandhi M, Tamilselvam M, Sursha V, Vigneshwara KT. Synthesis, Characterization, Antimicrobial Evaluation of 2-Amino pyrimidine Schiff base derivative. Research J. Pharm. and Tech. 2019; 12(4):1907-1909.

5. Suman Kumari, Vinita Gupta, Sanchita Singh, Gupta YK. Synthesis, Characterization and Antimicrobial Activities of Some New Amino-Pyrimidine Derivatives. Research J. Pharm. and Tech 2019; 12(1): 167-171.

6. Ingarsal N, Saravanan G, Amutha P, Nagarajan S. Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. Eur. J. Med. Chem. 2007; 42: 517-20.

7. Panda SS, Chowdary PVR. Synthesis of novel indolyl-pyrimidine anti-inflammatory, antioxidant and antibacterial agents. Ind. J. Pharm. Sci. 2008; 70(2): 208-15.

8. Ishwar Bhat K, Abhishek Kumar. Pyrimidines as Potent Antioxidant Agents. Research J. Pharm. and Tech 2018; 11(5):1927-1929.

9. Rangappa SK, Kallappa MH, Ramya VS, Mallinath HH. Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety. Eur. J. Med. Chem. 2010; 45: 2597-05. doi:10.1016/j.ejmech.2010.02.048.

10. Murugan R, Arjunan R, Austin M, Belsen J, Vijin P, Tom S. Synthesis of 2-Substituted Pyrimidines and Evaluation of Its Pharmacological Activities. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 161-164.

11. Ishwar Bhat K, Abhishek Kumar. Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives. Research J. Pharm. and Tech. 2017; 10(4): 1049-1052.

12. Ramesh B, Babitha S. Synthesis and anti-inflammatory activity of some new pyrimidine derivatives. Research J. Pharm. and Tech 2009; 2(4):830-832.

13. Ishwar Bhat K, Abhishek Kumar, Pankaj Kumar, Riyaz EK. Synthesis and Biological Evaluation of Some Novel Pyrimidine Derivatives Derived from Chalcones. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 995-998.

14. Anu A, Kumkum S, Puri SK, Sinha S, Prem MS. A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents. Bioorg. Med. Chem. Lett. 2005; 15: 5218-21.

15. Moni S, Vinita C, Manju YK, Shalini B, Kumkum S, Puri SK, Prem MS. Substituted quinolyl chalcones and quinonlinyl pyrimidines as a new class of anti-infective agents. Eur. J. Med. Chem. 2009; 44: 2081-91.

16. Diwakar R, Wenmin C, Ye Tian, Xuwang C, Peng Z, Erik DC, Christophe P, Jan B, Xinyong L. Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs. Bioorg. Med. Chem. 2013; 21: 7398-05.

17. Seerat F, Anindra S, Reshu S, Rajkamal T, Sanjeev KS, Swaroop KP, Renu T, Rama PT. One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents. Eur. J. Med. Chem. 2012; 55: 195-04.

18. Ramesh D, Chandrashekhar C, Vaidya VP. Synthesis, analgesic, anti-inflammatory and antimicrobial activities of naphtha [2,1-b] furan incorporated substituted pyrimidines. Ind. J. Het. Chem. Vol. 15, 2006, pp. 319-322.

19. Mondal SK, Chatraborty G, Gupta M, Mazumder UK. Invitro antioxidant activity of Dispyrosmalabarica Kostal bark. Ind. J Exp Biol. 2004; 44: 39-44.

20. Gulcin I, Oktay M, Vioglu IKO, Ali A. Determinations of antioxidant activity of lichen Cetrariaislandica (L) Ach. J. Ethanopharmacol. 2002; 79: 325-329.