Author(s): Suruj Kaushik, Amit Roy, Prerna Purabiya, Trilochan Satapathy

Email(s): surujkaushik59@gmail.com

DOI: 10.5958/0974-360X.2020.00198.5   

Address: Suruj Kaushik*, Amit Roy, Prerna Purabiya, Trilochan Satapathy
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh-493111, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020


ABSTRACT:
Objective: The aim of this study to evaluate the anti bacterial and anti-inflammatory effectiveness of Boswellia serrata standardized extract by in-vitro methods. Methods: The agar diffusion method has been adopted to evaluate the in vitro antibacterial activity of Boswellia serrata against Staphylococcus aureus and Escherchia coli by using Ciprofloxacin as standard drug. The test substance has been screened at different concentrations such as 25, 50, 100, 250, 500 and 1000 µg/ml. The in vitro anti inflammatory activities of Boswellia serrata standardized extract was performed at three different concentrations such as 10µg, 50µg and 100µg by using hyaluronidase enzyme inhibition assay. The absorbance of the final reaction mixture was measured at 600 nm. Results: The in vitro antibacterial activity of the test sample was evaluated at different concentrations and the diameter of inhibition zones in mm was evaluated. The results revealed that, Boswellia serrata extract at different concentrations provides a promising antimicrobial activity against S. aureus and E.coli. The test compound was screened in a range of 100µg -1000µg in the reaction mixture. The hyaluronidase inhibition potential of test compound was evaluated and calculated as the percentage ratio of the absorbance in presence of the test compound vs. positive control. Standard drug Indomethacin (Indo) was used as reference standard. The result revealed that the maximum (84.847%) hyaluronidase inhibition was observed at 100µl where as standard drug Indomethacin showed (98.21%) inhibition. Conclusions: The Standardized extract of Boswellia serrata exhibit significant anti bacterial and hyaluronidase inhibition activity in a dose dependent manner.


Cite this article:
Suruj Kaushik, Amit Roy, Prerna Purabiya, Trilochan Satapathy. Anti Bacterial and In Vitro Anti-inflammatory Potential of Boswellia seratta: A Potent Bioactive Compound. Research J. Pharm. and Tech 2020; 13(3): 1079-1082. doi: 10.5958/0974-360X.2020.00198.5

Cite(Electronic):
Suruj Kaushik, Amit Roy, Prerna Purabiya, Trilochan Satapathy. Anti Bacterial and In Vitro Anti-inflammatory Potential of Boswellia seratta: A Potent Bioactive Compound. Research J. Pharm. and Tech 2020; 13(3): 1079-1082. doi: 10.5958/0974-360X.2020.00198.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-3


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