A series of some new benzoxazines were synthesized and evaluated for antimicrobial activity. Benzoxazines are reported to possess a wide spectrum of biological properties such as anticancer, anti-microbial, antitubercular, antiplatelet, analgesic and anti-inflammatory activities. Regular clinical usage of anti-microbial drugs is allied with developing microbial resistance. Hence, the discovery of new safer antimicrobial drugs represents a demanding target for this research area. The reaction of 4-methoxy cyclohexanone with different aromatic aldehydes yield chalcones. 4-methoxy cyclohexanone was reacted with selected aromatic aldehydes which is an example for Claisen-Schmidt condensation. The title compounds were synthesized by treating chalcones with urea in presence of potassium hydroxide. Their structures were confirmed by IR, 1H-NMR and mass spectra. Anti-microbial activity was evaluated for the synthesized compounds. All synthesized compounds were evaluated for in vitro antibacterial activity and antifungal activity by cup plate method at 100µg/0.1 ml. Ampicillin and Amphoterician B were used as standard reference for comparing the antibacterial and antifungal activity respectively.
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Shabana Fathima, Bharath Rathna Kumar. P. Synthesis, Characterization and Anti-microbial Studies of (8E)-8-benzylidene-6-methoxy-4-phenyl-1,4,5,6,7,8-hexahydro-2H-3,1-benzoxazin-2-imine derivatives. Research J. Pharm. and Tech 2020; 13(3):1167-1170. doi: 10.5958/0974-360X.2020.00214.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-3-19
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