ABSTRACT:
Three simple, fast and economic UV-spectrophotometric methods were developed for the estimation of Bilastine in bulk and pharmaceutical formulation. For zero order (D0) ?max was measured at 281.60 nm. For first order method (D1) amplitude was measured at 280.20 nm (maxima) and 283.60 nm (minima). Bilastine obeyed Beer’s-Lambert’s law in the concentration range of 10-140 µg/ml for both zero order and first order methods. The % RSD value for both intra-day and inter-day precision was less than 2%. The methods were validated as per ICH guidelines for linearity, accuracy, precision and were found to be linear, accurate and precise.
Cite this article:
Peethala Prathyusha, Raja Sundararajan. UV spectrophotometric method for determination of Bilastine in bulk and pharmaceutical formulation. Research J. Pharm. and Tech 2020; 13(2):933-938. doi: 10.5958/0974-360X.2020.00176.6
Cite(Electronic):
Peethala Prathyusha, Raja Sundararajan. UV spectrophotometric method for determination of Bilastine in bulk and pharmaceutical formulation. Research J. Pharm. and Tech 2020; 13(2):933-938. doi: 10.5958/0974-360X.2020.00176.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-2-80