Author(s): Mahmood Kahtan, Ali Faris Hassan, Nada Naje Al-Shawi, Intesar Tareq Numan, Ghaith Abbas Bahader

Email(s): ali_1371982@yahoo.com

DOI: 10.5958/0974-360X.2020.00168.7   

Address: Mahmood Kahtan1, Ali Faris Hassan1, Nada Naje Al-Shawi1, Intesar Tareq Numan2, Ghaith Abbas Bahader3
1Pharmacology and Toxicology Department, College of Pharmacy, University of Baghdad, Baghdad, Iraq
2Pharmacology and Toxicology Department, College of Pharmacy, University of AL-Bayan, Baghdad, Iraq
3Pharmaceutical Chemistry Departments, College of Pharmacy, University of Baghdad, Baghdad, Iraq
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
Aim: The study designed to evaluate the Geno-protective effect of green tea extract against genotoxicity induced by metronidazole and tinidazole. Methods: Thirty-six mice were used, For each experiment, The animals divided into 6 groups: Group I- Negative control administered distilled water; Group II-Healthy mice treated with metronidazole alone, Group III- Healthy mice treated with tinidazole alone; Group IV- Healthy mice administered green tea extract alone Group V- Healthy mice treated with metronidazole, followed by green tea extract administration, Group VI- Healthy mice treated with tinidazole, followed by administration of green tea extract. Results: treatment with Tinidazole significantly increase total chromosomal aberration (0.185± 0.0039, 0.167±0.0049) as compared to negative control group (0.116±0.004, 0.103±0.004) in bone marrow and spleen cells respectively. In addition results showed significant change in total chromosomal aberration between the groups (II, IV, V) (0.122±0.012, 0.079±0.005, 0.101±0.0077) (0.121±0.005, 0.067±0.002, 0.087±0.004) in bone marrow cells and spleen cells respectively. In addition, the results shown that there are significant changes in total chromosomal aberration between the groups (III, IV, VI) (0.185±0.0039, 0.079±0.005, 0.133±0.0135) (0.167±0.0049, 0.067±0.002, 0.11±0.012) in bone marrow cells and spleen cells respectively. Conclusion: Tinidazole has greater effect than metronidazole on total chromosomal aberration and the aqueous extract of green tea confers Geno-protective effect against the metronidazole or tinidazole induced genotoxicity in mice.


Cite this article:
Mahmood Kahtan, Ali Faris Hassan, Nada Naje Al-Shawi, Intesar Tareq Numan, Ghaith Abbas Bahader. The Genoprotective Activity of Aqueous Green Tea extract against Metronidazole and Tinidazole Genotoxic Effect. Research J. Pharm. and Tech 2020; 13(2):889-894. doi: 10.5958/0974-360X.2020.00168.7

Cite(Electronic):
Mahmood Kahtan, Ali Faris Hassan, Nada Naje Al-Shawi, Intesar Tareq Numan, Ghaith Abbas Bahader. The Genoprotective Activity of Aqueous Green Tea extract against Metronidazole and Tinidazole Genotoxic Effect. Research J. Pharm. and Tech 2020; 13(2):889-894. doi: 10.5958/0974-360X.2020.00168.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-2-72


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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