ABSTRACT:
This is a comprehensive study of anti ulcer activity of Macrotyloma uniflorum (horse gram) on experimental gastric ulcer models in rats. Macrotyloma uniflorum, the whole seeds of horse gram are also known as Kulthi bean, Madras gram. In Telangana and Andhra Pradesh, horse gram is prescribed for persons suffering from jaundice or water retention, colic pain and ulcer and GI disorder. Its seeds are rich in linoleic acid and ester, mome inositol, alpha-d-glucopyranoside, vitamin E, ethyl derivatives, stigmasterol and 3-beta stigmast-5en-3-ol, phenolic acid. The present study evaluates the antiulcer activity of the ethanol extract of the seeds of Macrotyloma uniflorum by using pyloric ligation and stress induced ulcer model. Macrotyloma uniflorumhas already shown potent antioxidant activity and a potent antioxidant is obvious to show the healing capability as per as general pharmacology concern. In the pyloric ligation model the untreated control has shown 4.3 m Eq/L of acidity where as the ranitidine treated standard gp shown 2 m Eq/L and Macrotyloma uniflorum has shown 2.8 mEq/L acidity respectively. In the stress induced antiulcer model the activity was more prominent, in the untreated control there was 26 no of sores were present whereas the standard group shown only 1 number of ulcer sore and in the Macrotyloma uniflorum treated group there was 5 number of ulcer sore present. It is established that Macrotyloma uniflorumis having significant antiulcer activity while compare with the untreated control group.