Author(s): S. S. Sheeba Tabassum, C. Rajaram1, S. Nelson Kumar, R. Manohar, K. Ravindra Reddy

Email(s): ssheebatabassum@gmail.com

DOI: 10.5958/0974-360X.2020.00101.8   

Address: S. S. Sheeba Tabassum1*, C. Rajaram1, S. Nelson Kumar1, R. Manohar1, K. Ravindra Reddy2
1Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
2Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
Barleria cuspidata is considered as one of the medicinal plant which finds its use in traditional Indian medicine for treating various liver ailments. In previous studies it has been reported Barleria cuspidata showed antihelminthic activity, wound healing potential. There are no reports on hepatoprotective activity of this plant. The present study was planned to scientifically investigate the hepatoprotective activity of methanolic extract of Barleria cuspidata using CCl4 induced hepatotoxicity model. The animals were grouped into five groups of six animals each. Except the normal group all the other groups received carbon tetrachloride (CCl4) 50% v/v in coconut oil at a dose of 0.1 ml/kg b.w intraperitoneally for 28 days. Normal groups received plain coconut oil orally. The standard group received silymarin 50 mg/kg orally. Test groups received MEBC 200 mg/kg and 400mg/kg b.w orally. On the 28th day, blood samples were collected and serum was separated which is in turn used to analyze liver function tests such as SGOT, SGPT, ALP, Total bilirubin, total cholesterol, Alb, TP levels along with tests to check SOD, Catalase, GSH, MDA followed by histopathological studies. The results thus obtained showed significant improvement in these parameters and also in the cytoarchitecture of rat liver. Thus concluding that the methanolic extract of Barleria cuspidata possess hepatoprotective activity.


Cite this article:
S. S. Sheeba Tabassum, C. Rajaram1, S. Nelson Kumar, R. Manohar, K. Ravindra Reddy. Evaluation of Hepatoprotective activity of the Methanolic Extract of Barleria Cuspidata against CCl4 Induced Liver damage in Experimental Rats. Research J. Pharm. and Tech 2020; 13(2):538-542. doi: 10.5958/0974-360X.2020.00101.8


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Tarasankar Maity, Ayaz Ahmad, Nilanjan Pahari, Subarna Ganguli

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Jitendra Patel, A. Venkateshwar Reddy, G.S. Kumar, D. Satyasai4 B. Bajari, V. Nagarjuna

DOI: 10.5958/0974-360X.2017.00232.3         Access: Open Access Read More

Author(s): Neha Rajput, Dinesh Sachan, Shikha Gangwar, Dipti Sachan

DOI: Not Available         Access: Open Access Read More

Author(s): Inshah Ahmed, Nishat Ahmed, Saleha Ahmed, Fazil Ahmad, Abeer Mohammed Al-Subaie

DOI: 10.5958/0974-360X.2020.00451.5         Access: Closed Access Read More

Author(s): Subin Mary Zachariah, N. Aleykutty, Vidya Viswanad, Halima O.A.

DOI: Not Available         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): Tejashree N. Hagawane, Aashish M. Mahuvakar, Rajiv V. Gaikwad, Nilima A. Kshirsagar

DOI: Not Available         Access: Open Access Read More

Author(s): T. Sheela Rani, V. Gopal, S. Seethalakshmi, K. Chitra

DOI: Not Available         Access: Open Access Read More

Author(s): Saba Shaikh, Ravi Dubey, Swati Dhande, Y.M Joshi, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags