Author(s): Sooraj Surendran, Merin Babu, Jipnomon Joseph, Uma Devi Padma

Email(s): umadevip@aims.amrita.edu , umadeviaims@gmail.com

DOI: 10.5958/0974-360X.2020.00124.9   

Address: Sooraj Surendran, Merin Babu, Jipnomon Joseph, Uma Devi Padma*
Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi - 682041, Kerala, India
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
The present study was designed to find out the effect of piperine as an adjunctive therapy with sodium valproate against seizures induced by pentylenetetrazole (PTZ). Swiss albino mice (25-35g) received either vehicle, sodium valproate (300mg/kg), piperine (10mg/kg) or their combination orally for 8 days prior to PTZ (60mg/kg i.p.) administration. Sodium valproate significantly (P<0.05) increased the latency for clonic generalized seizures. Treatment with sodium valproate and piperine delayed the onset to both jerks (P<0.05) and clonic generalized seizures (P<0.001). All the animals in the combination group were protected from clonic generalized seizures. Our results suggest a favorable interaction of piperine with sodium valproate against PTZ induced seizures.


Cite this article:
Sooraj Surendran, Merin Babu, Jipnomon Joseph, Uma Devi Padma. Facilitatory effect of Piperine on the Anticonvulsant effect of Sodium valproate against Pentylenetetrazole induced Seizures in mice. Research J. Pharm. and Tech 2020; 13(2):651-652. doi: 10.5958/0974-360X.2020.00124.9


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Author(s): Jyothi.S, Karthikeyan Murthykumar, Anupama Deepak, Dhanraj, Noorul Aneesa, Sowndarya Baskar, Lakshya Rani

DOI: 10.5958/0974-360X.2016.00113.X         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): Kamal Hossain, Kamrun Nahar, Mohammed Ehsanul Hoque Mazumder

DOI: 10.5958/0974-360X.2017.00398.5         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags