Author(s): Rahul S Solunke, Ravindra A Dhawale, K J. kore, Madhuri T Deshmukh, Rutuja R F, Rajkumar V Shete

Email(s): ravindradhawale01@gmail.com

DOI: 10.5958/0974-360X.2020.00122.5   

Address: Rahul S Solunke2, Ravindra A Dhawale*1, K J. kore3, Madhuri T Deshmukh4, Rutuja R F5, Rajkumar V Shete6
1Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India. 2Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India.
3Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India.
4Department of Pharmaceutic’s, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune 412206, Maharashtra, India.
5Dr Vitthalrao Vikhe Patil Foundation College of Pharmacy, villad ghat, Ahmednagar 414111, Maharashtra India.
6Department of Pharmacology Rajgad Dnyanpeeth’s College of Pharmacy, Bhor Pune 412206, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
The current investigation is to formulate and develop enteric coated tablet of Ropinirole Hydrochloride. Enteric coated tablets were prepared by Wet Granulation method by using water as solvent. To protect drug from acid Eudragit L-100 was used as enteric coated polymer. Drug, Excipient and Polymer compatibility studies were performed by FTIR and DSC. The formulation was optimized with desirable Hardness, Friability and Disintegration time. Tablet exhibited Hardness between 5.1-5.8 Kg/Cm2, Friability 0.09-0.21 %, Disintegration time 40-60 minutes and drug release between 78-95.56 %. Optimized formula F4 showing the Friability 0.13 %, Hardness 5.5 Kg/Cm2 and drug release 95.56 %. Drug diffusion study was represented graphically.


Cite this article:
Rahul S Solunke, Ravindra A Dhawale, K J. kore, Madhuri T Deshmukh, Rutuja R F, Rajkumar V Shete. Formulation and Development of Enteric Coated Tablet for Parkinson’s Disease. Research J. Pharm. and Tech 2020; 13(2):639-644. doi: 10.5958/0974-360X.2020.00122.5


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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