Author(s): Atish Z. Dhadve, Anupama R. Dashetwar, Dipak P. Kardile, Rajkumar V. Shete

Email(s): atishdhadve@gmail.com

DOI: 10.5958/0974-360X.2020.00114.6   

Address: Atish Z. Dhadve1*, Anupama R. Dashetwar2, Dipak P. Kardile3, Rajkumar V. Shete4
1Department of Quality Assurance Techniques, Rajgad Dnyanpeeth’s College of Pharmacy Bhor, Dist-Pune 412206, Maharashtra, India.
2Department of Quality Assurance Technique, Rajgad Dnyanpeeth’s College of Pharmacy Bhor, Dist-Pune412206, Maharashtra, India.
3Department of Pharmaceutical Chemistry, Rajgad Dnyanpeeth’s College of Pharmacy Bhor, Dist-Pune 412206, Maharashtra, India.
4Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy Bhor, Dist-Pune 412206, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
To develop simple, selective, specific, accurate and rapid Stability Indicating RP-HPLC method for simultaneous determination of Atorvastatin and nicotinic acid from tablet dosage form. The chromatographic separations of two lipid lowering drug were carried out by using Thermo ODS (5µm. 150x4.6 mm i.d column) maintained at ambient temp (25°C) throughout the analysis. The drug was separated by using mobile phase consist of Acetonitrile and 0.1% acetic acid (70:30) by using isocratic elution mode separation at the flow rate of 1ml/min and detection wavelength of 245nm by using UV detector. The method were found to be linear over the concentration range of 2-10µg/ml and 75-375µg/ml with correlation coefficient0.9999 and 0.9960 for the atorvastatin and Nicotinic acid respectively. The retention time of Atorvastatin calcium and Nicotinic acid were 1.539 and 2.475 min. respectively The developed method was validated as per ICH guideline and successfully applied for determination of Atorvastatin calcium and Nicotinic acid in tablet dosage form.


Cite this article:
Atish Z. Dhadve, Anupama R. Dashetwar, Dipak P. Kardile, Rajkumar V. Shete. Stability Indicating RP-HPLC Method for Simultaneous Determination of Atorvastain and Nicotinic acid from Tablet Dosage Form. Research J. Pharm. and Tech 2020; 13(2):604-608. doi: 10.5958/0974-360X.2020.00114.6


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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