Author(s): G. Sowjanya, D. Parimala Pallavi, Oindrila Mazumder, S. Praveen Kumar

Email(s): tatinenijishnu@gmail.com

DOI: 10.5958/0974-360X.2020.00107.9   

Address: G. Sowjanya*, D. Parimala Pallavi, Oindrila Mazumder, S. Praveen Kumar
Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2020


ABSTRACT:
The present study deals with development and validation of a new derivative UV spectrophotometric method for simultaneous quantification of Tizanidine and Aceclofenac in tablets. Tizanidine and Aceclofenac were obtained as gift samples and a simple derivative method was developed in borate buffer pH 9.0 using double beam UV/Visible spectrophotometer. The absorbance of Tizanidine was measured at 250nm (zero crossing point of Aceclofenac) and for Aceclofenac, 308.92nm (zero crossing point of Tizanidine) was selected. The linearity of Tizanidine and Aceclofenac was found to be in the range of 0.1-40 µg/mL and 2-100 µg/mL respectively. The %RSD in precision study was found to be 0.014-1.92% (intraday) and 0.014-1.44% (inter day) indicating that the method was precise. The % recovery for both the drugs in combination was obtained in the range of 98 - 101.36 % and found no interference from excipients. The method was also found to be sensitive as observed from the LOD and LOQ values. The proposed method was validated as per ICH guidelines and can be conveniently used for quantification of Tizanidine and Aceclofenac in tablets.


Cite this article:
G. Sowjanya, D. Parimala Pallavi, Oindrila Mazumder, S. Praveen Kumar. Development and Validation of a New Derivative UV Spectrophotometric Method for Simultaneous Quantification of Tizanidine and Aceclofenac in Tablets. Research J. Pharm. and Tech 2020; 13(2):569-574. doi: 10.5958/0974-360X.2020.00107.9

Cite(Electronic):
G. Sowjanya, D. Parimala Pallavi, Oindrila Mazumder, S. Praveen Kumar. Development and Validation of a New Derivative UV Spectrophotometric Method for Simultaneous Quantification of Tizanidine and Aceclofenac in Tablets. Research J. Pharm. and Tech 2020; 13(2):569-574. doi: 10.5958/0974-360X.2020.00107.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-2-11


Recomonded Articles:

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): Karishma Ravinthar, Jayalakshmi

DOI: 10.5958/0974-360X.2018.00148.8         Access: Open Access Read More

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): G. Bhavani, R. Navaneethan

DOI: 10.5958/0974-360X.2017.00269.4         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Kalpana Kamnoore, M P Venkatesh, Balamuralidhara V, T M Pramod Kumar

DOI: 10.5958/0974-360X.2020.00276.0         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Ankit Patel, Pankaj Kushwah, Sujit Pillai, Ajay Raghuvanshi, Nitin Deshmukh

DOI: 10.5958/0974-360X.2017.00013.0         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Shyama S. Kumar, Divya Bhosle, Akshay Janghel, Shraddha Deo, Parijeeta Raut, Chetan Verma, Mukta Agrawal, Nisha Amit, Mukesh Sharma, Tapan Giri, D. K. Tripathi1, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2015.00099.2         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): M. A. Fazeelath Banu, Karthikeyan Murthykumar, Dr. Dhanraj

DOI: 10.5958/0974-360X.2016.00184.0         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags