Author(s): Mansi Shah, Dipti Patel

Email(s): dipti.patel@paruluniversity.ac.in

DOI: 10.5958/0974-360X.2020.01083.5   

Address: Mansi Shah1, Dipti Patel2*
1PhD Scholar, Parul Institute of Pharmacy and Research, Parul University, Vadodara.
2HOD Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
Tadalafil has low solubility and low oral bioavailability, so it’s a challenge to formulate suitable dosage form. In this Present investigation to enhance the dissolution rate and solubility skimmed milk is used as a carrier. Physical mixers were prepared using various drugs to carrier ratio. Material and Methods: Spry drying technology was used to prepared solid dispersion of drug with skimmed milk. Various techniques were used to characterize the solid dispersion immediately after they were made which includes Differential scanning calorimetry, fourier transform infrared spectroscopy, X-ray diffraction and in-vitro dissolution profiles. Results: The Differential Scanning Calorimetry thermograms of raw drug indicated of its anhydrous crystalline nature. In thermograms of solid dispersion, the characteristic peak was absent suggesting the change from crystalline nature to amorphous form. X-ray diffraction confirmed the results. The results of raw drug showed highly extreme peak characteristic of its crystalline nature where solid dispersion showed less intense, more diffused peak indicating the change in crystalline form. Fourier transform infrared spectroscopy studies indicated between drug and carrier there were no interaction. The whole formulation showed distinct enhancement in the drug release behavior and solubility. Conclusion: The optimum drug to carrier ratio 1:10 enhance the solubility and in-vitro drug release also increase by 3 fold. For improvement of drug release and solubility, it was concluded that as a carrier skimmed milk powder can be utilized very well.


Cite this article:
Mansi Shah, Dipti Patel. Development and Characterization of tadalafil solid dispersion using skimmed milk for improved the solubility and Dissolution release profile. Research J. Pharm. and Tech. 2020; 13(12):6212-6217. doi: 10.5958/0974-360X.2020.01083.5


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