Deepika P., Dhanya P., Naseef PP
Deepika P. 1, Dhanya P. 1, Naseef PP2*
1Jamia Salafiya Pharmacy College, Pulikkal, Malappuram, Kerala, India.
2Moulana College of Pharmacy, Perinthalmanna, Malappuram, Kerala, India.
Volume - 13,
Issue - 12,
Year - 2020
A new series of azetidin-2-one derivatives containing coumarin ring were designed and docked with the protein kinase C ? receptor (1XJD), the docking scores obtained for certain derivatives are better than the natural ligand and the standard. The compounds which showed good docking scores were synthesized and characterized by spectral data. The cytotoxic activity of the synthesized compounds was tested by MTT assay and the compounds showed good activity on HeLa cell lines.
Cite this article:
Deepika P., Dhanya P., Naseef PP. Docking Investigation, Synthesis and Cytotoxic Studies of Coumarin Substituted Azetidinone Derivatives. Research J. Pharm. and Tech. 2020; 13(12):6182-6185. doi: 10.5958/0974-360X.2020.01078.1
1 Kokila Parmar, Viral Modi, Sarju Prajapati, Rinku Patel. A facile and expeditious approach for the synthesis of 2-azetidinone derivatives with antimicrobial activity. Asian Journal of Biochemical and Pharmaceutical Research.2011; 1(2): 612
2 Mehta Parul D, A. K. Pathak. Two dimensional QSAR study of Some novel 2-azetidinone series for their antibacterial activity against Bacillus subtilis. International Journal of Pharm Tech Research. 2012; 4(2): 676-688
3 Deborah J. Kuhn, Yang Wang, Vesna Minic, Cristina Coates, G. Suresh Kumar Reddy, Kenyon G. Daniel. Structure-activity relationships of N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells. Frontiers in Bioscience. 2005; 10: 1183-1190
4 G. Veinberg, R. Bokaldere, K. Dikovskaya, M. Vorona, I. Kanepe. Synthesis of cytotoxic 1,3,4-trisubstituted 2-azetidinones. Chemistry of heterocyclic compounds. 2003; 39(5): 680-687
5 Toxicities of anticancer drugs and its management. International Journal of Basic and Clinical Pharmacology. 2012; 1(1): 2
6 S. Mirunalini, M. krishnaveni. Coumarin: A Plant derived Polyphenol with wide Biomedical Applications. International Journal of Pharm Tech Research. 2011; 3(3): 1695
7 Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J Immunol methods 16; 65(1-2):55-63
8 Fouzia Mesli, Radia Mahboub. Evolution of Thermodynamic and Structural Properties of Coumarins by Molecular Dynamics Simulation. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2010; 1(1): 84
9 Arora Pankaj, Das Sanjib, Arora Namita, Gawai Ashish, Baghel U.S. Synthesis and screening of some novel 7-Hydroxy 4-Methyl Coumarin derivatives for antipsychotic activity. International journal of pharmacy and life sciences. 2010; 1(3): 113-118
10 Deepak P. Kardile, Manchindra R. Holam, Ankit S. Patel, Shailesh B. Ramani. Synthesis and biological evaluation of (7-hydroxy-2-oxo-2h-chromen-4-yl) acetic acid hydrazide derivatives used as a potent biological agent. Rasayan. J. Chem. 2011; 4(1): 66-72
11 Mohamed N. Ibrahim, Salah E. A. Sharif. Synthesis, Characterization and Use of Schiff Bases as Fluorimetric Analytical Reagents. E-Journal of Chemistry. 2007; 4(4): 531-535
12 K.H. Patel, A.G. Mehta. Synthesis and antifungal activity of azetidinone and thiazolidinone derivative of 2-amino-6-(2-naphthalenyl) thiazolo[3,2-d] thiadiazole. E-Journal of Chemistry. 2006; 3(13): 267-273
13 Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J Immunol methods 16; 65(1-2):55-63
15 Schrodinger suite. Manual help index.2011